Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Melanie R Hassler"'
Autor:
Ursula Lemberger, Büsra Ernhofer, Sigurd Krieger, Andreas Bruchbacher, André Oszwald, Ekaterina Laukhtina, Andrea Haitl, Melanie R. Hassler, Bernhard Englinger, Eva Compérat, Shahrokh F. Shariat
Publikováno v:
European Urology Open Science, Vol 71, Iss , Pp 38-48 (2025)
Background and objective: The role of genetic variants in response to systemic therapy in muscle-invasive bladder cancer (MIBC) is still elusive. We assessed variations in genes involved in DNA damage repair (DDR) before and after cisplatin-based neo
Externí odkaz:
https://doaj.org/article/543b7ef7c4374be7977e14ee8e6b39f8
Autor:
Bettina Trimmel, Andre Oszwald, Christoph Diemand, Iris E. Ertl, Ursula Lemberger, Andreas Bruchbacher, Robert Brettner, Stephan Korn, Irene Resch, Eva Comperat, Shahrokh F. Shariat, Melanie R. Hassler
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Squamous cell carcinoma of the penis (PSC) is a rare disease with limited information on the molecular events leading to malignant transformation. In a third of PSC cases, presence of human papilloma virus (HPV) is found. The APOBEC3 family
Externí odkaz:
https://doaj.org/article/3aa2b5c569dc4bdc90c7d05d36bb9d7e
Autor:
Thomas Dillinger, Raheleh Sheibani-Tezerji, Walter Pulverer, Ines Stelzer, Melanie R. Hassler, Janine Scheibelreiter, Carlos Uziel Pérez Malla, Madeleine Kuroll, Sandra Domazet, Elisa Redl, Sarah Ely, Stefanie Brezina, Andreas Tiefenbacher, Katharina Rebhan, Nicolai Hübner, Bernhard Grubmüller, Markus Mitterhauser, Marcus Hacker, Andreas Weinhaeusel, Judit Simon, Markus Zeitlinger, Andrea Gsur, Gero Kramer, Shahrokh F. Shariat, Lukas Kenner, Gerda Egger
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-8 (2022)
Externí odkaz:
https://doaj.org/article/e7cd2e9f7a7d44b397802c49e598064c
Autor:
Judith Stangl-Kremser, Sazan Rasul, Jeffrey J. Tosoian, Simpa S. Salami, Alexander Zaslavsky, Aaron Udager, Peter Mazal, Renate Kain, Eva Comperat, Marcus Hacker, Alexander Haug, Markus Mitterhauser, Carmen Pozo-Salido, Christina Steinbach, Melanie R. Hassler, Gero Kramer, Shahrokh F. Shariat, Ganesh S. Palapattu
Publikováno v:
European Urology Open Science, Vol 30, Iss , Pp 63-66 (2021)
Initial reports of a clinical response in patients treated with the radioligand [177Lu]-PSMA-617 for castration-resistant prostate cancer (CRPC) are promising, despite known inter- and intrapatient heterogeneity. In metastatic CRPC, we examined the a
Externí odkaz:
https://doaj.org/article/a2b9edb485a247728f43555379aaa0bd
Autor:
Maša Zrimšek, Hana Kuchaříková, Kristina Draganić, Pavlína Dobrovolná, Verena Heiss Spornberger, Lisa Winkelmayer, Melanie R. Hassler, Gabriela Lochmanová, Zbyněk Zdráhal, Gerda Egger
Publikováno v:
Cells, Vol 11, Iss 15, p 2380 (2022)
Histone deacetylases (HDACs) target acetylated lysine residues in histone and non-histone proteins. HDACs are implicated in the regulation of genomic stability, cell cycle, cell death and differentiation and thus critically involved in tumorigenesis.
Externí odkaz:
https://doaj.org/article/efd61c7324fb49a5b4b37032ea4eba8d
Autor:
Ekaterina Laukhtina, Melanie R. Hassler, Benjamin Pradere, Takafumi Yanagisawa, Fahad Quhal, Pawel Rajwa, Reza Sari Motlagh, Frederik König, Maximilian Pallauf, Tatsushi Kawada, Hadi Mostafaei, David D'Andrea, Dmitry Enikeev, Shahrokh F. Shariat
Publikováno v:
European Urology Focus. 8:1683-1686
We summarise the available data for and assess the prognostic value of circulating tumour DNA (ctDNA) in patients treated with systemic therapy for urothelial carcinoma (UC). Studies were deemed eligible if they reported on oncologic outcomes for pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5111e07cd9f8c637d7b926a050fc7e9b
https://doi.org/10.1016/j.euf.2022.04.017
https://doi.org/10.1016/j.euf.2022.04.017
Autor:
Iris E. Ertl, Ursula Lemberger, Dafina Ilijazi, Melanie R. Hassler, Andreas Bruchbacher, Robert Brettner, Hannah Kronabitter, Michael Gutmann, Petra Vician, Gerhard Zeitler, Anna Koren, Charles-Hugues Lardeau, Thomas Mohr, Andrea Haitel, Eva Compérat, André Oszwald, Gabriel Wasinger, Thomas Clozel, Olivier Elemento, Stefan Kubicek, Walter Berger, Shahrokh F. Shariat
Publikováno v:
European Urology. 82:261-270
The heterogeneity of bladder cancers (BCs) is a major challenge for the development of novel therapies. However, given the high rates of recurrence and/or treatment failure, the identification of effective therapeutic strategies is an urgent clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a645a3f3589cd9885e3dc52540f270ca
https://doi.org/10.1016/j.eururo.2022.03.009
https://doi.org/10.1016/j.eururo.2022.03.009
Autor:
Eva Compérat, André Oszwald, Gabriel Wasinger, Johannes Kläger, Melanie R. Hassler, Shahrokh F. Shariat
Publikováno v:
Current Opinion in Urology. 32:451-455
To highlight the latest changes in prostate cancer (PCa), urothelial carcinoma, upper tract urothelial carcinoma (UTUC) and renal cell carcinoma (RCC) diagnosis and the impact of genetics in this field.Breast cancer1/2 mutations start to play a major
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::181d21600bc762b9689bc751afb83d22
https://doi.org/10.1097/mou.0000000000001025
https://doi.org/10.1097/mou.0000000000001025
Autor:
Melanie R. Hassler, Walter Pulverer, Ranjani Lakshminarasimhan, Elisa Redl, Julia Hacker, Gavin D. Garland, Olaf Merkel, Ana-Iris Schiefer, Ingrid Simonitsch-Klupp, Lukas Kenner, Daniel J. Weisenberger, Andreas Weinhaeusel, Suzanne D. Turner, Gerda Egger
Publikováno v:
Cell Reports, Vol 17, Iss 2, Pp 596-608 (2016)
Aberrant DNA methylation patterns in malignant cells allow insight into tumor evolution and development and can be used for disease classification. Here, we describe the genome-wide DNA methylation signatures of NPM-ALK-positive (ALK+) and NPM-ALK-ne
Externí odkaz:
https://doaj.org/article/ac19a1ab1bff47b19952fae16e455e81
Autor:
Dafina Ilijazi, Walter Pulverer, Iris E. Ertl, Ursula Lemberger, Shoji Kimura, Mohammad Abufaraj, David D’Andrea, Benjamin Pradere, Andreas Bruchbacher, Anna Graf, Francesco Soria, Martin Susani, Andrea Haitel, Luca Molinaro, Armin Pycha, Evi Comploj, Stephan Pabinger, Andreas Weinhäusel, Gerda Egger, Shahrokh F. Shariat, Melanie R. Hassler
Publikováno v:
Cells, Vol 9, Iss 8, p 1839 (2020)
Background: Bacillus Calmette-Guérin (BCG) immunotherapy, the standard adjuvant intravesical therapy for some intermediate and most high-risk non-muscle invasive bladder cancers (NMIBCs), suffers from a heterogenous response rate. Molecular markers
Externí odkaz:
https://doaj.org/article/837a12d883f24e87bf5c66e235db5396