Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Melanie P. Clements"'
Autor:
Claudia Garcia-Diaz, Anni Pöysti, Elisabetta Mereu, Melanie P. Clements, Lucy J. Brooks, Felipe Galvez-Cancino, Simon P. Castillo, Wenhao Tang, Gordon Beattie, Lilas Courtot, Sara Ruiz, Federico Roncaroli, Yinyin Yuan, Samuel Marguerat, Sergio A. Quezada, Holger Heyn, Simona Parrinello
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112472- (2023)
Summary: Glioblastoma (GBM) recurrence originates from invasive margin cells that escape surgical debulking, but to what extent these cells resemble their bulk counterparts remains unclear. Here, we generated three immunocompetent somatic GBM mouse m
Externí odkaz:
https://doaj.org/article/2511e84f6c4a4bdfa932c7945c113d09
Autor:
María Ángeles Marqués-Torrejón, Charles A. C. Williams, Benjamin Southgate, Neza Alfazema, Melanie P. Clements, Claudia Garcia-Diaz, Carla Blin, Nerea Arranz-Emparan, Jane Fraser, Noor Gammoh, Simona Parrinello, Steven M. Pollard
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
How neural stem cells can transition between states of proliferation and quiescence is unclear. Here, the authors identify Lrig1 as a specific marker for the primed quiescent state and demonstrate that Lrig1 maintains cells in a quiescent state via m
Externí odkaz:
https://doaj.org/article/3e0ce24ca18642ab920706ba35de6dae
Autor:
Lucy J. Brooks, Melanie P. Clements, Jemima J. Burden, Daniela Kocher, Luca Richards, Sara Castro Devesa, Leila Zakka, Megan Woodberry, Michael Ellis, Zane Jaunmuktane, Sebastian Brandner, Gillian Morrison, Steven M. Pollard, Peter B. Dirks, Samuel Marguerat, Simona Parrinello
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Glioma stem cells (GSCs) retain the ability to partially differentiate, but it is unclear how the brain microenvironment may influence this response. Here the authors show that glioblastoma cells infiltrating into the white matter acquire pre-oligode
Externí odkaz:
https://doaj.org/article/1dfd4c8671124520ac4d6ba779864aae
Autor:
Lucy J. Brooks, Melanie P. Clements, Jemima J. Burden, Daniela Kocher, Luca Richards, Sara Castro Devesa, Leila Zakka, Megan Woodberry, Michael Ellis, Zane Jaunmuktane, Sebastian Brandner, Gillian Morrison, Steven M. Pollard, Peter B. Dirks, Samuel Marguerat, Simona Parrinello
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/c6f6fdd59beb4ad2afd4c54046152174
Autor:
Valeria Amodeo, Timothy Davies, Amalia Martinez-Segura, Melanie P. Clements, Holly Simpson Ragdale, Andrew Bailey, Mariana Silva Dos Santos, James I. MacRae, Joao Mokochinski, Holger Kramer, Claudia Garcia-Diaz, Alex P. Gould, Samuel Marguerat, Simona Parrinello
Glioblastoma is thought to originate from neural stem cells (NSCs) of the subventricular zone that acquire genetic alterations. In the adult brain, NSCs are largely quiescent, suggesting that deregulation of quiescence maintenance may be a prerequisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b141e07ec3c27f17df3741ee017d3854
Autor:
Benjamin Krusche, Cristina Ottone, Melanie P Clements, Ewan R Johnstone, Katrin Goetsch, Huang Lieven, Silvia G Mota, Poonam Singh, Sanjay Khadayate, Azhaar Ashraf, Timothy Davies, Steven M Pollard, Vincenzo De Paola, Federico Roncaroli, Jorge Martinez-Torrecuadrada, Paul Bertone, Simona Parrinello
Publikováno v:
eLife, Vol 5 (2016)
Glioblastomas (GBM) are aggressive and therapy-resistant brain tumours, which contain a subpopulation of tumour-propagating glioblastoma stem-like cells (GSC) thought to drive progression and recurrence. Diffuse invasion of the brain parenchyma, incl
Externí odkaz:
https://doaj.org/article/99e030f6989e4de2bac103b0da9fd5ea
Publikováno v:
Neurobiology of Learning and Memory. 64:276-284
Calcium channel antagonists have previously been shown to alleviate age-associated reductions in memory acquisition and enhance retention for a number of different tasks. We have investigated the effects of pretraining injections of nifedipine, nimod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e8c8021bbae22460b660e2afdba90d
https://doi.org/10.1006/nlme.1995.0010
https://doi.org/10.1006/nlme.1995.0010
Publikováno v:
Neurobiology of Learning and Memory. 66:91-92
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::facc34e6f55fc9daadff92f84f5c46ec
https://doi.org/10.1006/nlme.1996.0048
https://doi.org/10.1006/nlme.1996.0048