Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Melanie Mumau"'
Autor:
Sheila K. Pierson, Laura Katz, Reece Williams, Melanie Mumau, Michael Gonzalez, Stacy Guzman, Ayelet Rubenstein, Ana B. Oromendia, Philip Beineke, Alexander Fosså, Frits van Rhee, David C. Fajgenbaum
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Idiopathic multicentric Castleman disease (iMCD) is a life-threatening inflammatory disease requiring immediate intervention, for which the recommended first-line therapy is the Interleukin-6 pathway inhibitor siltuximab. Authors here show that the c
Externí odkaz:
https://doaj.org/article/e0c518f68f5145bd81577393f7c19dec
Publikováno v:
Blood. 140:5500-5501
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36683950169e4ff699a021a4ba972b21
https://doi.org/10.1182/blood-2022-167829
https://doi.org/10.1182/blood-2022-167829
Autor:
Yiqing Yang, Melanie Mumau, Joanna Tober, Qin Zhu, Laura Bennett, Courtney Hong, Derek Sung, Thomas Keller, Yasin Uzun, Peng Gao, Swapnil Shewale, Mei Chen, Jisheng Yang, Xiaowen Chen, Steven A. Thomas, Kai Tan, Nancy A. Speck, Mark L. Kahn
Publikováno v:
Blood
The hematopoietic stem cells (HSCs) that produce blood for the lifetime of an animal arise from RUNX1+ hemogenic endothelial cells (HECs) in the embryonic vasculature through a process of endothelial-to-hematopoietic transition (EHT). Studies have id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50701ddd18b02edec90655bfc65e547c
https://europepmc.org/articles/PMC9101247/
https://europepmc.org/articles/PMC9101247/
Hemogenic endothelial (HE) cells in the dorsal aorta undergo an endothelial to hematopoietic transition (EHT) to form lympho-myeloid biased progenitors (LMPs), pre-hematopoietic stem cells (pre-HSCs) and adult-repopulating HSCs. These briefly accumul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03af4633f82a140b06e10be264ba0910
https://doi.org/10.1101/2021.07.21.453199
https://doi.org/10.1101/2021.07.21.453199
Autor:
Elizabeth D. Howell, Nancy A. Speck, Wenbao Yu, Peng Gao, Yan Li, Qin Zhu, Kai Tan, Changya Chen, Bing He, Joanna Tober, Laura Bennett, Melanie Mumau, Yasin Uzun
Publikováno v:
Blood
Hematopoietic stem and progenitor cells (HSPCs) in the bone marrow are derived from a small population of hemogenic endothelial (HE) cells located in the major arteries of the mammalian embryo. HE cells undergo an endothelial to hematopoietic cell tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c2bdf501d8671892e1cac60bf5d6d09
https://europepmc.org/articles/PMC7426642/
https://europepmc.org/articles/PMC7426642/
Autor:
Jennifer A. Punt, Stephen G. Emerson, Elizabeth D. Lynch, Sophia B. Golec, Melanie Mumau, Ashley N. Vanderbeck
Publikováno v:
The Journal of Immunology. 200:1078-1087
The developmental fate of hematopoietic stem and progenitor cells is influenced by their physiological context. Although most hematopoietic stem and progenitor cells are found in the bone marrow of the adult, some are found in other tissues, includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af6462492d3f415ac8c824314a059a30
https://doi.org/10.4049/jimmunol.1701250
https://doi.org/10.4049/jimmunol.1701250
Publikováno v:
Immunity
Summary Hematopoietic stem cells (HSCs) are generated from specialized endothelial cells of the embryonic aorta. Inflammatory factors are implicated in regulating mouse HSC development, but which cells in the aorta-gonad-mesonephros (AGM) microenviro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e39db3859e56dae50040e08e6d15d107
https://pubmed.ncbi.nlm.nih.gov/31178352
https://pubmed.ncbi.nlm.nih.gov/31178352
Autor:
Larry L. Luchsinger, Hans-Willem Snoeck, Melanie Mumau, Mariana Justino de Almeida, David J. Corrigan
Publikováno v:
Nature
Haematopoietic stem cells (HSCs), which sustain production of all blood cell lineages, rely on glycolysis for ATP production, yet little attention has been paid to the role of mitochondria. Here we show in mice that the short isoform of a critical re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c20312b8a47faf2f7dedbcb7ef2082
https://doi.org/10.1038/nature16500
https://doi.org/10.1038/nature16500
Autor:
Hans-Willem Snoeck, Zheng Hu, Gordana Vunjak-Novakovic, Jahar Bhattacharya, Michael D. Green, Ya-Wen Chen, Yong-Guang Yang, Sarah X.L. Huang, John D. O’Neill, Melanie Mumau, Mohammad Naimul Islam
Publikováno v:
Nature biotechnology
The ability to generate lung and airway epithelial cells from human pluripotent stem cells (hPSCs) would have applications in regenerative medicine, drug screening and modeling of lung disease, and studies of human lung development. We established, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf26ee9403ad6c26ede3b56b95540c6
https://doi.org/10.1038/nbt.2754
https://doi.org/10.1038/nbt.2754
Autor:
Laura Grisanti, Su-Yi Tsai, Carlos Clavel, Melanie Mumau, Chen-Leng Cai, Xiaoqiang Cai, Amélie Rezza, Michael Rendl, Rachel Sennett
Publikováno v:
The Journal of investigative dermatology
How cell fate decisions of stem and progenitor cells are regulated by their microenvironment or niche is a central question in stem cell and regenerative biology. Although functional analysis of hair follicle epithelial stem cells by gene targeting i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b24e2f7079f4c1477ed859dac9441a0