Výsledky vyhledávání - "Melanie Manetsch"

Akademický článek

Long-acting β2-agonists increase fluticasone propionate-induced mitogen-activated protein kinase phosphatase 1 (MKP-1) in airway smooth muscle cells.

Autor: Melanie Manetsch, Md Mostafizur Rahman, Brijeshkumar S Patel, Emma E Ramsay, Nowshin N Rumzhum, Hatem Alkhouri, Qi Ge, Alaina J Ammit

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e59635 (2013)

Mitogen-activated protein kinase phosphatase 1 (MKP-1) represses MAPK-driven signalling and plays an important anti-inflammatory role in asthma and airway remodelling. Although MKP-1 is corticosteroid-responsive and increased by cAMP-mediated signall

Externí odkaz: https://doaj.org/article/49fde66458a4423a8d7bf12640ac086c

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Akademický článek

Inhibition of mitogen-activated protein kinase Erk1/2 promotes protein degradation of ATP binding cassette transporters A1 and G1 in CHO and HuH7 cells.

Autor: Vishwaroop Mulay, Peta Wood, Melanie Manetsch, Masoud Darabi, Rose Cairns, Monira Hoque, Karen Cecilia Chan, Meritxell Reverter, Anna Alvarez-Guaita, Kerry-Anne Rye, Carles Rentero, Joerg Heeren, Carlos Enrich, Thomas Grewal

Publikováno v: PLoS ONE, Vol 8, Iss 4, p e62667 (2013)

Signal transduction modulates expression and activity of cholesterol transporters. We recently demonstrated that the Ras/mitogen-activated protein kinase (MAPK) signaling cascade regulates protein stability of Scavenger Receptor BI (SR-BI) through Pr

Externí odkaz: https://doaj.org/article/84c70b55205c40c1ab31fa16bdb9987d

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Corticosteroids and β2-agonists upregulate mitogen-activated protein kinase phosphatase 1: in vitro mechanisms

Autor: Emma Ramsay, David E. Hibbs, Elizabeth M. King, Petra Seidel, Robert Newton, Wenchi Che, Qi Ge, Alaina J. Ammit, Melanie Manetsch

Publikováno v: British Journal of Pharmacology. 166:2049-2059

BACKGROUND AND PURPOSE Airway remodelling is a consequence of long-term inflammation and MAPKs are key signalling molecules that drive pro-inflammatory pathways. The endogenous MAPK deactivator – MAPK phosphatase 1 (MKP-1) – is a critical negativ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44fa4c335130b8046a19f76009ba0378
https://doi.org/10.1111/j.1476-5381.2012.01923.x

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MKP-1: A negative feedback effector that represses MAPK-mediated pro-inflammatory signaling pathways and cytokine secretion in human airway smooth muscle cells

Autor: Alaina J. Ammit, Petra Seidel, Melanie Manetsch, Yang Chen, Wenchi Che

Publikováno v: Cellular Signalling. 24:907-913

Airway smooth muscle (ASM) plays an important immunomodulatory role in airway inflammation in asthma. In our previous in vitro studies in ASM cells delineating the pro-inflammatory mitogen-activated protein kinase (MAPK) signaling pathways activated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a04239baf24a2a6b53f7a4c5c3d57b06
https://doi.org/10.1016/j.cellsig.2011.12.013

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Novel p38 MAPK inhibitor ML3403 has potent anti-inflammatory activity in airway smooth muscle

Autor: Alaina J. Ammit, Lenka Munoz, Emma Ramsay, Melanie Manetsch, Christian Peifer, Qi Ge, Stefan Laufer

Publikováno v: European Journal of Pharmacology. 635:212-218

SB203580 is the prototypical p38 MAPK inhibitor; however it cannot be used clinically due to liver toxicity. We developed a structural analogue of SB203580 - ML3403 - with equal in vitro and ex vivo p38alpha MAPK inhibition as SB203580, but with redu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d05907f85e067249e6183f10fdf6626
https://doi.org/10.1016/j.ejphar.2010.02.037

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Proteasomal inhibition upregulates the endogenous MAPK deactivator MKP-1 in human airway smooth muscle: Mechanism of action and effect on cytokine secretion

Autor: John P. Moutzouris, Wenchi Che, Qi Ge, Melanie Manetsch, Hatem Alkhouri, Emma Ramsay, Alaina J. Ammit, Anna M. Bjorkman, Friederike Schuster

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1803(3):416-423

Asthma is a chronic inflammatory condition. Inhibition of the ubiquitin-proteasome system offers promise as a anti-inflammatory strategy, being responsible for the degradation of key proteins involved in crucial cellular functions, including gene exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e5794601bff8ca73a8d859bcc67ae1f

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The nucleotide-binding domain and leucine-rich repeat protein-3 inflammasome is not activated in airway smooth muscle upon toll-like receptor-2 ligation

Autor: Hanna Im, Kristin Bunge, Christopher D. Pascoe, Mostafizur Rahman, Brian G. Oliver, Nowshin N. Rumzhum, Hatem Alkhouri, Alaina J. Ammit, Melanie Manetsch, Jeremy A. Hirota

Publikováno v: American journal of respiratory cell and molecular biology. 49(4)

Inflammasomes have emerged as playing key roles in inflammation and innate immunity. A growing body of evidence has suggested that the nucleotide-binding domain and leucine-rich repeat protein-3 (NLRP3) inflammasomeisimportant inchronic airwaydisease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc6db3278c9fd83acc387e95086cfce1
https://pubmed.ncbi.nlm.nih.gov/23614732

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Inhibition of Mitogen-Activated Protein Kinase Erk1/2 Promotes Protein Degradation of ATP Binding Cassette Transporters A1 and G1 in CHO and in HuH7 cells

Autor: Masoud Darabi, Karen Cecilia Chan, Vishwaroop Mulay, Thomas Grewal, Meritxell Reverter, Carles Rentero, Carlos Enrich, Anna Alvarez-Guaita, Monira Hoque, Kerry-Anne Rye, Peta Wood, Rose Cairns, Melanie Manetsch, Joerg Heeren

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
PLoS ONE, Vol 8, Iss 4, p e62667 (2013)
Dipòsit Digital de la UB
Universidad de Barcelona
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061798c17a6ba3417650825630e3d6f6
http://hdl.handle.net/2445/42447

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TLR2 ligand engagement upregulates airway smooth muscle TNFa-induced cytokine production

Autor: Alaina J. Ammit, Qi Ge, Udo Heintz, Wenchi Che, Melanie Manetsch, J. Margaret Hughes, Petra Seidel, Maria B. Sukkar

Airway inflammation and respiratory infections are important factors contributing to disease exacerbation in chronic airway diseases such as asthma and chronic obstructive pulmonary disease. Airway smooth muscle (ASM) cells express Toll-like receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a113905a52d7e93d005a15be35f5de
https://hdl.handle.net/10453/22153

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