Výsledky vyhledávání - "Melanie M. Hoefer"

IFNβ Protects Neurons from Damage in a Murine Model of HIV-1 Associated Brain Injury

Autor: Melanie M. Hoefer, Marcus Kaul, Alan M. O’Neill, Victoria E. Thaney, Ana B. Sanchez, Ricky Maung

Publikováno v: Scientific reports, vol 7, iss 1
Scientific Reports

Infection with human immunodeficiency virus-1 (HIV-1) causes brain injury. Type I interferons (IFNα/β) are critical mediators of any anti-viral immune response and IFNβ has been implicated in the temporary control of lentiviral infection in the br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7d504822d384e4c480bc27ebf1970d4
https://escholarship.org/uc/item/6tp147xb

Zobrazit plný text záznamu

CCR5 Knockout Prevents Neuronal Injury and Behavioral Impairment Induced in a Transgenic Mouse Model by a CXCR4-Using HIV-1 Glycoprotein 120

Autor: Marcus Kaul, Rossella Russo, Cyrus M. de Rozieres, Natalia E. Sejbuk, Maya K. Desai, Cari C. Dowling, Melanie M. Hoefer, Gwenn A. Garden, Ana B. Sanchez, Roy Williams, Ricky Maung, Amanda J. Roberts, Kathryn E. Medders, Irene C. Catalan

Publikováno v: The Journal of Immunology. 193:1895-1910

The innate immune system has been implicated in several neurodegenerative diseases, including HIV-1–associated dementia. In this study, we show that genetic ablation of CCR5 prevents microglial activation and neuronal damage in a transgenic model o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74d087d5466c2ec2a4484eb26a314b74
https://doi.org/10.4049/jimmunol.1302915

Zobrazit plný text záznamu

SHEP1 partners with CasL to promote marginal zone B-cell maturation

Autor: Yann Wallez, Derek V. Ostertag, Cecille D. Browne, Suresh K. Chintalapati, Robert C. Rickert, Elena B. Pasquale, Matthew H. Cato, Melanie M. Hoefer

Publikováno v: Proceedings of the National Academy of Sciences. 107:18944-18949

The marginal zone is a cellular niche bordering the marginal sinus of the spleen that contains specialized B-cell and macrophage subsets poised to capture bloodborne antigens. Marginal zone B cells are retained in this niche by integrin-mediated sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64915cc89e895025c303a76a51751dc8
https://doi.org/10.1073/pnas.1007558107

Zobrazit plný text záznamu

Ectodomain shedding and generation of two carboxy-terminal fragments of human complement receptor 2/CD21

Autor: Melanie M. Hoefer, Harald Illges

Publikováno v: Molecular Immunology. 46:2630-2639

Numerous cell surface proteins are functionally regulated by a proteolytic cleavage event termed ‘ectodomain shedding’. The complement receptor 2/CD21 extracellular domain (ectodomain) is constitutively released as a soluble form (sCD21), but its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be491764cc36db7e778958011734a89
https://doi.org/10.1016/j.molimm.2009.04.036

Zobrazit plný text záznamu

Antiretrovirals, Methamphetamine, and HIV-1 Envelope Protein gp120 Compromise Neuronal Energy Homeostasis in Association with Various Degrees of Synaptic and Neuritic Damage

Autor: Marcus Kaul, Giuseppe P. Varano, Ricky Maung, Melanie M. Hoefer, Cari C. Dowling, Irene C. Catalan, Ana B. Sanchez, Natalia E. Sejbuk, Cyrus M. de Rozieres

Publikováno v: Antimicrobial agents and chemotherapy, vol 60, iss 1

HIV-1 infection frequently causes HIV-associated neurocognitive disorders (HAND) despite combination antiretroviral therapy (cART). Evidence is accumulating that components of cART can themselves be neurotoxic upon long-term exposure. In addition, ab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efa69109580e8a65c1b10f56a98dbefb
https://europepmc.org/articles/PMC4704202/

Zobrazit plný text záznamu

Possible tetramerisation of the proteasome maturation factor POMP/proteassemblin/hUmp1 and its subcellular localisation

Autor: Stefan Grotegut, Harald Illges, Melanie M. Hoefer, Eva-Maria Boneberg, Justine Kusch

Publikováno v: International Journal of Biological Macromolecules. 38:259-267

The proteasome is a multisubunit complex with a central role in non-lysosomal proteolysis and the processing of proteins for presentation by the MHC class I pathway. The 16kDa proteasome maturation protein POMP (also named proteassemblin or hUmp1) ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90ec4d172dd46bccd2763f878e566863
https://doi.org/10.1016/j.ijbiomac.2006.03.015

Zobrazit plný text záznamu

Combination of methamphetamine and HIV-1 gp120 causes distinct long-term alterations of behavior, gene expression, and injury in the central nervous system

Autor: Melanie M. Hoefer, Cari C. Dowling, Victoria E. Thaney, Ricky Maung, Amanda J. Roberts, Cyrus M. de Rozieres, Marcus Kaul, Juan C. Piña-Crespo, Irene C. Catalan, Dongxian Zhang, Ana B. Sanchez

Methamphetamine (METH) abuse is frequent in individuals infected with human immunodeficiency virus type-1 (HIV-1) and is suspected to aggravate HIV-associated neurocognitive disorders (HAND). METH is a psychostimulant that compromises several neurotr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b91fe39076b777559ac600d397d0de3
https://escholarship.org/uc/item/0vj6d49v

Zobrazit plný text záznamu

Angiogenesis and lymphangiogenesis are downregulated in primary breast cancer

Autor: Gertrude M. Beer, Gregor Fürstenberger, H Steininger, Melanie M. Hoefer, C Ohlschlegel, Daniel F. Legler, H.-J. Senn, Eva-Maria Boneberg, Florian Otto, Dupont-Lampert, L Füzesi

Publikováno v: British Journal of Cancer

Background: Angiogenesis and lymphangiogenesis are considered to play key roles in tumour growth, progression and metastasis. However, targeting tumour angiogenesis in clinical trials showed only modest efficacy. We therefore scrutinised the concept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa9bf92763ef7e0880f9c42348cf271

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání