Immunogenicity phase II study evaluating booster capacity of nonadjuvanted AKS-452 SARS-Cov-2 RBD Fc vaccine

Autor: David G. Alleva, Eline A. Feitsma, Yester F. Janssen, Hendrikus H. Boersma, Thomas M. Lancaster, Thillainaygam Sathiyaseelan, Sylaja Murikipudi, Andrea R. Delpero, Melanie M. Scully, Ramya Ragupathy, Sravya Kotha, Jeffrey R. Haworth, Nishit J. Shah, Vidhya Rao, Shashikant Nagre, Shannon E. Ronca, Freedom M. Green, Stephen A. Shaw, Ari Aminetzah, Schelto Kruijff, Maarten Brom, Gooitzen M. van Dam, Todd C. Zion

Publikováno v: npj Vaccines, Vol 9, Iss 1, Pp 1-12 (2024)

Abstract AKS-452, a subunit vaccine comprising an Fc fusion of the ancestral wild-type (WT) SARS-CoV-2 virus spike protein receptor binding domain (SP/RBD), was evaluated without adjuvant in a single cohort, non-randomized, open-labelled phase II stu

Externí odkaz: https://doaj.org/article/3e169ceb8cc4445682f02ab1847c3f9e

Phase I interim results of a phase I/II study of the IgG-Fc fusion COVID-19 subunit vaccine, AKS-452

Autor: Yester F. Janssen, Eline A. Feitsma, Hendrikus H. Boersma, David G. Alleva, Thomas M. Lancaster, Thillainaygam Sathiyaseelan, Sylaja Murikipudi, Andrea R. Delpero, Melanie M. Scully, Ramya Ragupathy, Sravya Kotha, Jeffrey R. Haworth, Nishit J. Shah, Vidhya Rao, Shashikant Nagre, Shannon E. Ronca, Freedom M. Green, Ari Aminetzah, Frans Sollie, Schelto Kruijff, Maarten Brom, Gooitzen M. van Dam, Todd C. Zion

Publikováno v: Vaccine
Vaccine, 40(9), 1253-1260. ELSEVIER SCI LTD

To address the coronavirus disease 2019 (COVID-19) pandemic caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a recombinant subunit vaccine, AKS-452, is being developed comprising an Fc fusion protein of the SARS-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323329ba0f3a6ae40363118135c37a0a
http://europepmc.org/articles/PMC8802018

Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation.

Autor: Campbell EL; Mucosal Inflammation Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address: eric.campbell@ucdenver.edu., Bruyninckx WJ; Department of Biology, Hanover College, Hanover, IN 47243, USA., Kelly CJ; Mucosal Inflammation Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Glover LE; Mucosal Inflammation Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., McNamee EN; Mucosal Inflammation Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Bowers BE; Mucosal Inflammation Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Bayless AJ; Mucosal Inflammation Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Scully M; Mucosal Inflammation Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Saeedi BJ; Mucosal Inflammation Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Golden-Mason L; University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Ehrentraut SF; Mucosal Inflammation Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Curtis VF; Mucosal Inflammation Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Burgess A; Mucosal Inflammation Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Garvey JF; University College Dublin, Dublin 4, Ireland., Sorensen A; University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Nemenoff R; University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Jedlicka P; University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Taylor CT; University College Dublin, Dublin 4, Ireland., Kominsky DJ; Mucosal Inflammation Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Colgan SP; Mucosal Inflammation Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.

Publikováno v: Immunity [Immunity] 2014 Jan 16; Vol. 40 (1), pp. 66-77. Date of Electronic Publication: 2014 Jan 09.

An endogenously anti-inflammatory role for methylation in mucosal inflammation identified through metabolite profiling.

Autor: Kominsky DJ; Department of Anesthesiology and Perioperative Medicine, University of Colorado Health Science Center, Aurora, CO 80045, USA. Douglas.Kominsky@ucdenver.edu, Keely S, MacManus CF, Glover LE, Scully M, Collins CB, Bowers BE, Campbell EL, Colgan SP

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2011 Jun 01; Vol. 186 (11), pp. 6505-14. Date of Electronic Publication: 2011 Apr 22.

Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxification.

Autor: Campbell EL; Mucosal Inflammation Program, Department of Medicine, University of Colorado, Aurora, CO 80045, USA., MacManus CF, Kominsky DJ, Keely S, Glover LE, Bowers BE, Scully M, Bruyninckx WJ, Colgan SP

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2010 Aug 10; Vol. 107 (32), pp. 14298-303. Date of Electronic Publication: 2010 Jul 26.