Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages

Autor: Suzanne A.E. van Wouw, Marlene van den Berg, Maroua El Ouraoui, Amber Meurs, Jenina Kingma, Roelof Ottenhoff, Melanie Loix, Marten A. Hoeksema, Koen Prange, Gerard Pasterkamp, Jerome J.A. Hendriks, Jeroen F.J. Bogie, Jan B. van Klinken, Frederic M. Vaz, Aldo Jongejan, Menno P.J. de Winther, Noam Zelcer

Publikováno v: Journal of Lipid Research, Vol 64, Iss 2, Pp 100325- (2023)

Lysoplasmalogens are a class of vinyl ether bioactive lipids that have a central role in plasmalogen metabolism and membrane fluidity. The liver X receptor (LXR) transcription factors are important determinants of cellular lipid homeostasis owing to

Externí odkaz: https://doaj.org/article/5be45c9062f1454c8a49dcd0a8d8b7ff

Liver X Receptor Alpha Is Important in Maintaining Blood-Brain Barrier Function

Autor: Elien Wouters, Nienke M. de Wit, Jasmine Vanmol, Susanne M. A. van der Pol, Bert van het Hof, Daniela Sommer, Melanie Loix, Dirk Geerts, Jan Ake Gustafsson, Knut R. Steffensen, Tim Vanmierlo, Jeroen F. J. Bogie, Jerome J. A. Hendriks, Helga E. de Vries

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Dysfunction of the blood-brain barrier (BBB) contributes significantly to the pathogenesis of several neuroinflammatory diseases, including multiple sclerosis (MS). Potential players that regulate BBB function are the liver X receptors (LXRs), which

Externí odkaz: https://doaj.org/article/56fc8933ec1142a69ee5c39bf8b09233

Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity

Autor: Elien Grajchen, Melanie Loix, Paulien Baeten, Beatriz F. Côrte-Real, Ibrahim Hamad, Sam Vanherle, Mansour Haidar, Jonas Dehairs, Jelle Y. Broos, James M. Ntambi, Robert Zimmermann, Rolf Breinbauer, Piet Stinissen, Niels Hellings, Sanne G. S. Verberk, Gijs Kooij, Martin Giera, Johannes V. Swinnen, Bieke Broux, Markus Kleinewietfeld, Jerome J. A. Hendriks, Jeroen F. J. Bogie

Publikováno v: Cellular and Molecular Immunology, 20(6), 666-679. Nature Publishing Group
Grajchen, E, Loix, M, Baeten, P, Côrte-Real, B F, Hamad, I, Vanherle, S, Haidar, M, Dehairs, J, Broos, J Y, Ntambi, J M, Zimmermann, R, Breinbauer, R, Stinissen, P, Hellings, N, Verberk, S G S, Kooij, G, Giera, M, Swinnen, J V, Broux, B, Kleinewietfeld, M, Hendriks, J J A & Bogie, J F J 2023, ' Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity ', Cellular and Molecular Immunology, vol. 20, no. 6, pp. 666-679 . https://doi.org/10.1038/s41423-023-01011-2

The imbalance between pathogenic and protective T cell subsets is a cardinal feature of autoimmune disorders such as multiple sclerosis (MS). Emerging evidence indicates that endogenous and dietary-induced changes in fatty acid metabolism have a majo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0453077196c63a160f7fb022361b2740
https://cris.maastrichtuniversity.nl/en/publications/91c2f0c1-489d-4001-92ff-b59bf00eacea

Extracellular vesicle-associated cholesterol dictates the regenerative functions of macrophages in the brain

Autor: Sam Vanherle, Jeroen Guns, Melanie Loix, Fleur Mingneau, Tess Dierckx, Tim Vangansewinkel, Esther Wolfs, Paula Pincela Lins, Annelies Bronckaers, Ivo Lambrichts, Jonas Dehairs, Johannes V. Swinnen, Sanne G.S. Verberk, Mansour Haidar, Jerome J.A. Hendriks, Jeroen F.J. Bogie

Macrophages play major roles in the pathophysiology of various neurological disorders, being involved in seemingly opposing processes such as lesion progression and resolution. Yet, the molecular mechanisms that drive their harmful and benign effecto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99b120ea3d280c88a5f9ab4c9c9f6f88
https://doi.org/10.1101/2022.12.23.521775

The ApoA-I mimetic peptide 5A enhances remyelination by promoting clearance and degradation of myelin debris

Autor: Sam Vanherle, Winde Jorissen, Tess Dierckx, Melanie Loix, Elien Grajchen, Fleur Mingneau, Jeroen Guns, Pascal Gervois, Ivo Lambrichts, Jonas Dehairs, Johannes V. Swinnen, Monique T. Mulder, Alan T. Remaley, Mansour Haidar, Jerome J.A. Hendriks, Jeroen J.F. Bogie

Publikováno v: Cell Reports, 41(6):111591. Cell Press

The progressive nature of demyelinating diseases lies in the inability of the central nervous system (CNS) to induce proper remyelination. Recently, we and others demonstrated that a dysregulated innate immune response partially underlies failure of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a987079cca7a30d80a99841aa1e71327
https://doi.org/10.1016/j.celrep.2022.111591