Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Melanie Legrand"'
Publikováno v:
Journal of Fungi, Vol 8, Iss 7, p 650 (2022)
The heterozygous diploid genome of Candida albicans displays frequent genomic rearrangements, in particular loss-of-heterozygosity (LOH) events, which can be seen on all eight chromosomes and affect both laboratory and clinical strains. LOHs, which a
Externí odkaz:
https://doaj.org/article/126a4847538044a6b28e431fdeb1427e
Publikováno v:
mSphere, Vol 5, Iss 5 (2020)
ABSTRACT Most of our knowledge relating to molecular mechanisms of human fungal pathogenesis in Candida albicans relies on reverse genetics approaches, requiring strain engineering. DNA-mediated transformation of C. albicans has been described as hig
Externí odkaz:
https://doaj.org/article/cdc40270ef2740f2a5459b3e3b97d217
Autor:
Timea Marton, Adeline Feri, Pierre-Henri Commere, Corinne Maufrais, Christophe d’Enfert, Melanie Legrand
Publikováno v:
mSphere, Vol 4, Iss 1 (2019)
ABSTRACT The heterozygous diploid genome of Candida albicans is highly plastic, with frequent loss of heterozygosity (LOH) events. In the SC5314 laboratory strain, while LOH events are ubiquitous, a chromosome homozygosis bias is observed for certain
Externí odkaz:
https://doaj.org/article/a4f19e583b0040988497b79b9662e61f
Autor:
Melanie Legrand, Anja Forche, Anna Selmecki, Christine Chan, David T Kirkpatrick, Judith Berman
Publikováno v:
PLoS Genetics, Vol 4, Iss 1, p e1 (2008)
Haplotype maps (HapMaps) reveal underlying sequence variation and facilitate the study of recombination and genetic diversity. In general, HapMaps are produced by analysis of Single-Nucleotide Polymorphism (SNP) segregation in large numbers of meioti
Externí odkaz:
https://doaj.org/article/3024c2f1b8924f339f8c7d54d7fded08
Autor:
Murielle Chauvel, Sophie Bachellier-Bassi, Anne-Marie Guérout, Keunsook K. Lee, Corinne Maufrais, Emmanuelle Permal, Juliana Pipoli Da Fonseca, Sadri Znaidi, Didier Mazel, Carol A. Munro, Christophe d’Enfert, Melanie Legrand
Publikováno v:
Research in Microbiology
Research in Microbiology, 2023, 174 (3), pp.104025. ⟨10.1016/j.resmic.2022.104025⟩
Research in Microbiology, 2023, 174 (3), pp.104025. ⟨10.1016/j.resmic.2022.104025⟩
International audience; Candida albicans is a major fungal pathogen of humans. Although its genome has been sequenced more than two decades ago, there are still over 4300 uncharacterized C. albicans genes. We previously generated an ORFeome as well a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae4f8cdb7829f98dd3d30defb3f7461a
https://hal-pasteur.archives-ouvertes.fr/pasteur-04131602/file/1-s2.0-S0923250822001061-main.pdf
https://hal-pasteur.archives-ouvertes.fr/pasteur-04131602/file/1-s2.0-S0923250822001061-main.pdf
Autor:
Priya Brahma, Priya Jaitly, Abhijit Das, Rohit Goyal, Melanie Legrand, Christophe d'Enfert, Kaustuv Sanyal
Publikováno v:
Medical Mycology. 60
Poster session 3, September 23, 2022, 12:30 PM - 1:30 PM Objective Morphological plasticity is one of the key attributes of microbial pathogens contributing to the successful establishment of infection in host tissues. Candida albicans, an opportunis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad98c99c68aa76c88229ddc873cff16a
https://doi.org/10.1093/mmy/myac072.p328
https://doi.org/10.1093/mmy/myac072.p328
Autor:
Sophie Bachellier-Bassi, Lasse van Wijlick, Melanie Legrand, Murielle Chauvel, Laxmi Shanker Rai, Christophe d'Enfert
Publikováno v:
Molecular Microbiology
Molecular Microbiology, 2022, 117 (3), pp.589-599. ⟨10.1111/mmi.14818⟩
Molecular Microbiology, 2022, 117 (3), pp.589-599. ⟨10.1111/mmi.14818⟩
International audience; Candida albicans is an opportunistic fungal pathogen that is responsible for infections linked to high mortality. Loss-of-function approaches, taking advantage of gene knockouts or inducible down-regulation, have been successf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24cc157513ff84e43142951bc5c1c6b4
https://hal.inrae.fr/hal-03755737/document
https://hal.inrae.fr/hal-03755737/document
Autor:
Kaustuv Sanyal, Tejas Patel, Melanie Legrand, Christophe d'Enfert, Priya Jaitly, Murielle Chauvel, Abhijit Das
Publikováno v:
Nature Communications
Nature Communications, 2022, 13 (1), pp.4256. ⟨10.1038/s41467-022-31980-3⟩
Nature Communications, 2022, 13 (1), pp.4256. ⟨10.1038/s41467-022-31980-3⟩
Chromosomal instability in fungal pathogens caused by cell division errors is associated with antifungal drug resistance. To identify mechanisms underlying such instability and to uncover new potential antifungal targets, we conducted an overexpressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26fb404cdfd5f9a2d56bef4a6f92693d
https://pubmed.ncbi.nlm.nih.gov/35869076
https://pubmed.ncbi.nlm.nih.gov/35869076
Autor:
Laxmi Shanker Rai, Murielle Chauvel, Hiram Sanchez, Lasse van Wijlick, Corinne Maufrais, Thomas Cokelaer, Natacha Sertour, Mélanie Legrand, Kaustuv Sanyal, David R Andes, Sophie Bachellier-Bassi, Christophe d'Enfert
Publikováno v:
PLoS Biology, Vol 22, Iss 6, p e3002693 (2024)
Candida albicans is a commensal of the human microbiota that can form biofilms on implanted medical devices. These biofilms are tolerant to antifungals and to the host immune system. To identify novel genes modulating C. albicans biofilm formation, w
Externí odkaz:
https://doaj.org/article/950f30e96bf34aa18748985f1e9630d6
Publikováno v:
Fungal Genetics and Biology. 48:823-830
Genome rearrangements, a common feature of Candida albicans isolates, are often associated with the acquisition of antifungal drug resistance. In Saccharomyces cerevisiae, perturbations in the S-phase checkpoints result in the same sort of Gross Chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b3c76a0fd19659db5ffcc1f810c78a
https://doi.org/10.1016/j.fgb.2011.04.005
https://doi.org/10.1016/j.fgb.2011.04.005