Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Melanie L, Hutton"'
Autor:
Steven J. Mileto, Melanie L. Hutton, Sarah L. Walton, Antariksh Das, Lisa J. Ioannidis, Don Ketagoda, Kylie M. Quinn, Kate M. Denton, Diana S. Hansen, Dena Lyras
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
Clostridioides difficile is the most common cause of infectious antibiotic-associated diarrhea, with disease mediated by two major toxins TcdA and TcdB. In severe cases, systemic disease complications may arise, resulting in fatal disease. Systemic d
Externí odkaz:
https://doaj.org/article/aa191c606e3d4d01907ecf57b6745d17
Autor:
Avinash V. Karpe, Melanie L. Hutton, Steven J. Mileto, Meagan L. James, Chris Evans, Amol B. Ghodke, Rohan M. Shah, Suzanne S. Metcalfe, Jian-Wei Liu, Tom Walsh, Dena Lyras, Enzo A. Palombo, David J. Beale
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1636 (2023)
Apicomplexan infections, such as giardiasis and cryptosporidiosis, negatively impact a considerable proportion of human and commercial livestock populations. Despite this, the molecular mechanisms of disease, particularly the effect on the body beyon
Externí odkaz:
https://doaj.org/article/db84e36e524e4318a1a1bca1dd82130f
Autor:
Mohammad M. Rahman, Alexandra Tikhomirova, Joyanta K. Modak, Melanie L. Hutton, Claudiu T. Supuran, Anna Roujeinikova
Publikováno v:
Gut Pathogens, Vol 12, Iss 1, Pp 1-7 (2020)
Abstract With the rise of bacterial resistance to conventional antibiotics, re-purposing of Food and Drug Administration (FDA) approved drugs currently used to treat non-bacteria related diseases as new leads for antibacterial drug discovery has beco
Externí odkaz:
https://doaj.org/article/f7789a24a4624956acb4bbf49a1e26c0
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 15, Iss 2, Pp 508-513 (2019)
Debilitating recurrent urinary tract infections (UTIs) are often associated with gastrointestinal colonisation by uropathogens, such as uropathogenic Escherichia coli (UPEC), suggesting that these populations might be a suitable target for the treatm
Externí odkaz:
https://doaj.org/article/66cf6212a35b4c0caa7a58d11aca9de0
Autor:
Muni Kumar Mahadari, Sreenu Jennepalli, Andrew J. Tague, Papanin Putsathit, Melanie L. Hutton, Katherine A. Hammer, Daniel R. Knight, Thomas V. Riley, Dena Lyras, Paul A. Keller, Stephen G. Pyne
Publikováno v:
Antibiotics, Vol 10, Iss 8, p 913 (2021)
Clostridioides (also known as Clostridium) difficile is a Gram-positive anaerobic, spore producing bacterial pathogen that causes severe gastrointestinal infection in humans. The current chemotherapeutic options are inadequate, expensive, and limited
Externí odkaz:
https://doaj.org/article/d7a93aa001934ee6ae056243ed218bbe
Autor:
Avinash V. Karpe, Melanie L. Hutton, Steven J. Mileto, Meagan L. James, Chris Evans, Rohan M. Shah, Amol B. Ghodke, Katie E. Hillyer, Suzanne S. Metcalfe, Jian-Wei Liu, Tom Walsh, Dena Lyras, Enzo A. Palombo, David J. Beale
Publikováno v:
Metabolites, Vol 11, Iss 6, p 380 (2021)
Cryptosporidiosis is a major human health concern globally. Despite well-established methods, misdiagnosis remains common. Our understanding of the cryptosporidiosis biochemical mechanism remains limited, compounding the difficulty of clinical diagno
Externí odkaz:
https://doaj.org/article/d440e1d4863b4a40a4b7ac06b4d87df7
Autor:
Melanie L. Hutton, Bliss A. Cunningham, Kate E. Mackin, Shelley A. Lyon, Meagan L. James, Julian I. Rood, Dena Lyras
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract The increased incidence of antibiotic resistant ‘superbugs’ has amplified the use of broad spectrum antibiotics worldwide. An unintended consequence of antimicrobial treatment is disruption of the gastrointestinal microbiota, resulting i
Externí odkaz:
https://doaj.org/article/287f80b5616c443694627a600e1f3867
Autor:
Marion S. Tissera, Daniel Cowley, Nada Bogdanovic-Sakran, Melanie L. Hutton, Dena Lyras, Carl D. Kirkwood, Jim P. Buttery
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 13, Iss 4, Pp 921-927 (2017)
Rotavirus gastroenteritis is a leading global cause of mortality and morbidity in young children due to diarrhea and dehydration. Over 85% of deaths occur in developing countries. In industrialised countries, 2 live oral rotavirus vaccines licensed i
Externí odkaz:
https://doaj.org/article/b4ac8b19955445e688157582e16aa540
Autor:
Priscilla A. Johanesen, Kate E. Mackin, Melanie L. Hutton, Milena M. Awad, Sarah Larcombe, Jacob M. Amy, Dena Lyras
Publikováno v:
Genes, Vol 6, Iss 4, Pp 1347-1360 (2015)
Clostridium difficile is well recognized as the leading cause of antibiotic-associated diarrhea, having a significant impact in both health-care and community settings. Central to predisposition to C. difficile infection is disruption of the gut micr
Externí odkaz:
https://doaj.org/article/0ca334eca936477db794935cd57e2fb6
Autor:
Avinash V Karpe, Melanie L Hutton, Steven J Mileto, Meagan L James, Chris Evans, Amol B Ghodke, Rohan M Shah, Suzanne S Metcalfe, Jian-Wei Liu, Tom Walsh, Dena Lyras, Enzo A Palombo, David J Beale
Apicomplexan infections, such as giardiasis and cryptosporidiosis, negatively impact a considerable proportion of human and commercial livestock populations. Despite this, the molecular mecha-nisms of disease, particularly the effect on the body beyo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6357e19d44da886e219df11ea927821c
https://doi.org/10.20944/preprints202212.0094.v1
https://doi.org/10.20944/preprints202212.0094.v1