Regulation of Arthritis Severity by the Acid Sphingomyelinase

Autor: Nadine Beckmann, Katrin Anne Becker, Silke Walter, Jan U. Becker, Melanie Kramer, Gabriele Hessler, Stefanie Weber, Joachim R. Göthert, Klaus Fassbender, Erich Gulbins, Alexander Carpinteiro

Publikováno v: Cellular Physiology and Biochemistry, Vol 43, Iss 4, Pp 1-1 (2017)

Background/Aims: Rheumatoid arthritis is a chronic autoimmune disease hallmarked by inflammation in synovial joints. Treatment is hampered by the lack of a cure and current disease-modifying drugs are associated with potentially severe toxicities. Me

Externí odkaz: https://doaj.org/article/c32f3f2b8f5946a0b61eea168f4e802d

Mitochondrial Kv1.3 Channels as Target for Treatment of Multiple Myeloma

Autor: Stephanie Kadow, Fabian Schumacher, Melanie Kramer, Gabriele Hessler, René Scholtysik, Sara Oubari, Patricia Johansson, Andreas Hüttmann, Hans Christian Reinhardt, Burkhard Kleuser, Mario Zoratti, Andrea Mattarei, Ildiko Szabò, Erich Gulbins, Alexander Carpinteiro

Publikováno v: Cancers; Volume 14; Issue 8; Pages: 1955

Despite several new developments in the treatment of multiple myeloma, all available therapies are only palliative without curative potential and all patients ultimately relapse. Thus, novel therapeutic options are urgently required to prolong surviv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e9190564df863f3b8e1853db506236
https://pubmed.ncbi.nlm.nih.gov/35454865

Clinical Development of Sphingosine as Anti-Bacterial Drug: Inhalation of Sphingosine in Mini Pigs has no Adverse Side Effects

Autor: Burkhard Kleuser, Fabian Schumacher, Katrin Anne Becker, Simone Keitsch, Daniel Herrmann, Matthias Soddemann, Rabea Verhaegh, Claudine Kühn, Erich Gulbins, Ashraf Swaidan, Alexander Carpinteiro, Gero Hilken, Melanie Kramer, Barbara Wilker, Marko Dubicanac, A. Wissmann, Michael J. Edwards, Carolin Sehl, Henning Carstens, Markus Kamler

Publikováno v: Cellular Physiology and Biochemistry, Vol 53, Iss 6, Pp 1015-1028 (2019)

BACKGROUND/AIMS: Pulmonary infections with Pseudomonas aeruginosa (P. aeruginosa) or Staphylococcus aureus (S. aureus) are of utmost clinical relevance in patients with cystic fibrosis, chronic obstructive pulmonary disease, after trauma and burn, up

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477ac5a6e3d1d0b757469079e97b19c5
https://doi.org/10.33594/000000194

Pathological manifestations of Farber disease in a new mouse model

Autor: Stefanie Kesper, Joachim R. Göthert, Alexander Carpinteiro, Katrin Anne Becker, Walter J. Schulz-Schaeffer, Stephanie Kadow, Erich Gulbins, Jan U. Becker, Annette Draeger, Nadine Beckmann, Melanie Kramer, Jiang Wang, Fabian Schumacher, Claudine Kühn, Burkhard Kleuser

Publikováno v: Beckmann, Nadine; Kadow, Stephanie; Schumacher, Fabian; Göthert, Joachim R; Kesper, Stefanie; Draeger, Annette; Schulz-Schaeffer, Walter J; Wang, Jiang; Becker, Jan U; Kramer, Melanie; Kühn, Claudine; Kleuser, Burkhard; Becker, Katrin Anne; Gulbins, Erich; Carpinteiro, Alexander (2018). Pathological manifestations of Farber disease in a new mouse model. Biological chemistry, 399(10), pp. 1183-1202. De Gruyter 10.1515/hsz-2018-0170

Farber disease (FD) is a rare lysosomal storage disorder resulting from acid ceramidase deficiency and subsequent ceramide accumulation. No treatments are clinically available and affected patients have a severely shortened lifespan. Due to the low i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a855418472c6e11354cc9f797cff54

Das Auf und Ab im Erwerbssystem – Berufliche Mobilität von Türken und Deutschen

Autor: Melanie Kramer, Wolfgang Lauterbach

Publikováno v: Integration durch Bildung ISBN: 9783531155685

Ein standiges Streben nach sozialer Gerechtigkeit und Chancengleichheit fuhrt zu dem wissenschaftlichen und offentlichen sowie politischen Interesse an Mobilitatschancen – insbesondere an vertikaler, soziale Grenzen uberschreitender Mobilitat in de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2775050edb94f1f175f01a1a90db7159
https://doi.org/10.1007/978-3-531-93232-3_10