Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Melanie Kaufholz"'
Autor:
Jan Hasenauer, Tim Hucho, Jörg Isensee, Humberto Gonczarowska-Jorge, Friedrich W. Herberg, René P. Zahedi, Frank Schwede, Matthias J. Knape, Hanna Hammerich, Melanie Kaufholz
Publikováno v:
The Journal of Cell Biology
J. Cell Biol. 217, 2167-2184 (2018)
J. Cell Biol. 217, 2167-2184 (2018)
Activity of endogenous protein kinase A (PKA) could never be analyzed directly in the cellular environment. Isensee et al. used antibodies to quantify conformational changes leading to an open conformation of endogenous PKA-II holoenzymes, which allo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30631b822930025843be65a446f91c1f
http://europepmc.org/articles/PMC5987717
http://europepmc.org/articles/PMC5987717
Autor:
J. Peter, Frank Schwede, Viola Spahn, C. Kasper, Tim Hucho, Jörg Isensee, Melanie Kaufholz, Christoph Stein, Sven-Eric Jordt, René Buschow, Friedrich W. Herberg, M. Brackmann
Background The ion channel TRPV1 is mainly expressed in small diameter dorsal root ganglion (DRG) neurons, which are involved in the sensation of acute noxious thermal and chemical stimuli. Direct modifications of the channel by diverse signalling ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df9b165a8c043fcbce9a70d8d9de830
https://europepmc.org/articles/PMC5504413/
https://europepmc.org/articles/PMC5504413/
Autor:
Apirat Chaikuad, Tracy Keates, Cécile Vincke, Melanie Kaufholz, Michael Zenn, Zimmermann Bastian, Carlos Gutiérrez, Rong-Guang Zhang, Catherine Hatzos-Skintges, Andrzej Joachimiak, Serge Muyldermans, Herberg, Friederich W., Knapp, S., Muller, S.
Publikováno v:
Biochemical Journal; Vol 459
Vrije Universiteit Brussel
Biochemical Journal
Vrije Universiteit Brussel
Biochemical Journal
GAK (cyclin G-associated kinase) is a key regulator of clathrin-coated vesicle trafficking and plays a central role during development. Additionally, due to the unusually high plasticity of its catalytic domain, it is a frequent ‘off-target’ of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::28494c44a0dbcb3f60d6899956ca5071
Autor:
Anke Prinz, Mandy Diskar, Daniel Sohmen, Michael Boshart, Alexandra Kaupisch, Hans-Michael Zenn, Manuela Zaccolo, Melanie Kaufholz, Marco Berrera, Friedrich W. Herberg, Stefanie Brockmeyer
Publikováno v:
Journal of Biological Chemistry. 285:35910-35918
cAMP-dependent protein kinases are reversibly complexed with any of the four isoforms of regulatory (R) subunits, which contain either a substrate or a pseudosubstrate autoinhibitory domain. The human protein kinase X (PrKX) is an exemption as it is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f466eee13f67529969d2882b5f738fb9
https://doi.org/10.1074/jbc.m110.155150
https://doi.org/10.1074/jbc.m110.155150
Autor:
Patrick E. MacDonald, Hans G. Genieser, Frank Schwede, Xiaodong Cheng, Yingmin Zhu, Fang C Mei, Jocelyn E. Manning Fox, Daniela Bertinetti, George G. Holz, Friedrich W. Herberg, Over Cabrera, Oleg G. Chepurny, Melanie Kaufholz, Colin A. Leech
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 29(7)
cAMP-elevating agents such as the incretin hormone glucagon-like peptide-1 potentiate glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells. However, a debate has existed since the 1970s concerning whether or not cAMP signaling is esse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d909f64501a17be59260e709e7c412f5
https://pubmed.ncbi.nlm.nih.gov/26061564
https://pubmed.ncbi.nlm.nih.gov/26061564
Autor:
Lutz Kummer, Anke Prinz, Petra Parizek, Friedrich W. Herberg, Bastian Millgramm, Peter Rube, Melanie Kaufholz, Andreas Plückthun, Peer R. E. Mittl, Bastian Zimmermann
Publikováno v:
Proceedings of the National Academy of Sciences; Vol 109
We have selected designed ankyrin repeat proteins (DARPins) from a synthetic library by using ribosome display that selectively bind to the mitogen-activated protein kinase ERK2 (extracellular signal-regulated kinase 2) in either its nonphosphorylate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62376985a4d4ca242a5a7a9e61b7021d
https://europepmc.org/articles/PMC3427131/
https://europepmc.org/articles/PMC3427131/
Autor:
Christopher J. MacNevin, Bastian Zimmermann, Chia Wen Hsu, Onur Dagliyan, Klaus M. Hahn, Lutz Kummer, Andreas Plückthun, Melanie Kaufholz, Nikolay V. Dokholyan
Publikováno v:
Chemistry & Biology
Chemistry & Biology; Vol 20
Chemistry & Biology; Vol 20
Investigation of protein activation in living cells is fundamental to understand how proteins are influenced by the full complement of upstream regulators they experience. We describe here the generation of a biosensor based on the Designed Ankyrin R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d82ed2acd6b847a961b25c3a50020502