Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Melanie K. Shadoan"'
Autor:
David R Powell, Deon D Doree, Christopher M DaCosta, Kenneth A Platt, Robert Brommage, Lindsey Buhring, Jean-Pierre Revelli, Melanie K Shadoan
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.
David R Powell,1 Deon D Doree,1 Christopher M DaCosta,1 Kenneth A Platt,2 Robert Brommage,1 Lindsey Buhring,1 Jean-Pierre Revelli,1 Melanie K Shadoan1 1Department of Pharmaceutical Biology, Lexicon Pharmaceuticals, Inc, The Woodlands, TX, USA; 2Depar
Autor:
David R, Powell, Deon D, Doree, Christopher M, DaCosta, Kenneth A, Platt, Robert, Brommage, Lindsey, Buhring, Jean-Pierre, Revelli, Melanie K, Shadoan
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Purpose Humans with haploinsufficiency of GPR75, an orphan GPCR, are thin. Gpr75 knockout (KO) mice are also thin with improved glucose homeostasis. We wanted to confirm these findings in Gpr75 KO mice and determine whether decreased energy intake an
Autor:
Qingyun Liu, Sabrina Jeter-Jones, Dawn Bright, Sofia Movérare-Skrtic, Peter Vogel, Jeff Liu, David Potter, Arthur T. Sands, Faika Mseeh, Petra Henning, Ulf H. Lerner, Robert Brommage, David R. Powell, Karin H Nilsson, James E. Tarver, Claes Ohlsson, Andrea Y. Thompson, Gwenn M. Hansen, Jennifer Bardenhagen, Brian Zambrowicz, Melanie K. Shadoan, Jie Cui, Deon Doree
Publikováno v:
Bone Research, Vol 7, Iss 1, Pp 1-12 (2019)
Bone Research
Bone Research
The disability, mortality and costs caused by non-vertebral osteoporotic fractures are enormous. Existing osteoporosis therapies are highly effective at reducing vertebral but not non-vertebral fractures. Cortical bone is a major determinant of non-v
Autor:
Lynley D Pound, Suparna A Sarkar, Alessandro Ustione, Prasanna K Dadi, Melanie K Shadoan, Catherine E Lee, Jay A Walters, Masakazu Shiota, Owen P McGuinness, David A Jacobson, David W Piston, John C Hutton, David R Powell, Richard M O'Brien
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40972 (2012)
The SLC30A8 gene encodes the islet-specific transporter ZnT-8, which is hypothesized to provide zinc for insulin-crystal formation. A polymorphic variant in SLC30A8 is associated with altered susceptibility to type 2 diabetes. Several groups have exa
Externí odkaz:
https://doaj.org/article/b95eb3a5326d42179669db493b53d656
Autor:
Kristen E. Syring, Kayla A. Boortz, James K. Oeser, David W. Piston, Owen P. McGuinness, Melanie K. Shadoan, Richard M. O'Brien, David R. Powell, Kenneth A. Platt, Alessandro Ustione
Publikováno v:
Endocrinology. 157:4534-4541
Polymorphisms in the SLC30A8 gene, which encodes the ZnT8 zinc transporter, are associated with altered susceptibility to type 2 diabetes (T2D), and SLC30A8 haploinsufficiency is protective against the development of T2D in obese humans. SLC30A8 is p
Autor:
Melanie K. Shadoan, Philip Manton Brown, Arthur T. Sands, Phillip Banks, David R. Powell, Kenny Frazier, Nicole Cathleen Goodwin, Brian Zambrowicz, Ross Mabon, Bryce Alden Harrison, J Bronner, David B. Rawlins, Joel Freiman, Faika Mseeh, Anne Turnage, D Ruff, Alan Wilson
Publikováno v:
Clinical Pharmacology and Therapeutics
Thirty-six patients with type 2 diabetes mellitus (T2DM) were randomized 1:1:1 to receive a once-daily oral dose of placebo or 150 or 300 mg of the dual SGLT1/SGLT2 inhibitor LX4211 for 28 days. Relative to placebo, LX4211 enhanced urinary glucose ex
Autor:
Brenda Gerhardt, Brian Zambrowicz, Melanie K. Shadoan, Brian D. Hamman, Matthias Schneider, Jason Allen, Isaac Van Sligtenhorst, Adisak Suwanichkul, Deon D. Smith, Sabrina Jeter-Jones, Kenneth A. Platt, Jay Mitchell, Urvi Desai, Katerina V. Savelieva, Laura L. Kirkpatrick, Peter Vogel, David R. Powell, Jean-Pierre Revelli, James Syrewicz
Publikováno v:
Obesity. 19:1010-1018
The kinase suppressor of ras 2 (KSR2) gene resides at human chromosome 12q24, a region linked to obesity and type 2 diabetes (T2D). While knocking out and phenotypically screening mouse orthologs of thousands of druggable human genes, we found KSR2 k
Autor:
Jan Domin, Nianhua Xu, Christopher M. DaCosta, David P. Harris, Karen Moberg, Marie Wims, Kanchan G. Jhaver, Juliane Humphries, Melanie K. Shadoan, Tamas Oravecz, Sanjeevi Balakrishnan, Peter Vogel, David R. Powell, Gwenn M. Hansen
Publikováno v:
Molecular and Cellular Biology. 31:63-80
An early lesion in many kidney diseases is damage to podocytes, which are critical components of the glomerular filtration barrier. A number of proteins are essential for podocyte filtration function, but the signaling events contributing to developm
Autor:
Christopher M. DaCosta, J. Wingert, Peter Vogel, Lindsey Buhring, R. Read, Melanie K. Shadoan, Gwenn M. Hansen
Publikováno v:
Veterinary Pathology. 48:642-654
Congenital generalized lipodystrophy (CGL) comprises a heterogeneous group of rare diseases associated with partial or total loss of adipose tissue. Of these, autosomal recessive Berardinelli–Seip congenital lipodystrophy (BSCL) is characterized by
Autor:
H. James Harwood, Kylie Kavanagh, Gina M. Ward, Melanie K. Shadoan, Omar L. Francone, Bruce Auerbach, Li Zhang, Janice D. Wagner, Lori Royer
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 333:844-853
Peroxisome proliferator-activated receptors (PPARs) are involved in the regulation of lipid and glucose metabolism. PPARgamma agonists improve insulin sensitivity and hyperglycemia and are effective in treating type 2 diabetes mellitus (T2DM), wherea