Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Melanie K O'Rourke"'
Autor:
Guiping Wang, David J Simon, Zhuhao Wu, Deanna M Belsky, Evan Heller, Melanie K O'Rourke, Nicholas T Hertz, Henrik Molina, Guisheng Zhong, Marc Tessier-Lavigne, Xiaowei Zhuang
Publikováno v:
eLife, Vol 8 (2019)
Axon degeneration sculpts neuronal connectivity patterns during development and is an early hallmark of several adult-onset neurodegenerative disorders. Substantial progress has been made in identifying effector mechanisms driving axon fragmentation,
Externí odkaz:
https://doaj.org/article/429de975562348739835760a335b1078
Autor:
Garam Kim, Melanie K. O’Rourke, Laura D. Attardi, Rebecca J. Shen, Deanna M Belsky, Marc Tessier-Lavigne, Margot E. Bowen, Jason Pitts, David J. Simon, Christine Y.J. Ohn
Publikováno v:
Dev Cell
Axon remodeling through sprouting and pruning contributes to the refinement of developing neural circuits. A prominent example is the pruning of developing sensory axons deprived of neurotrophic support, which is mediated by a caspase-dependent (apop
Autor:
Charles W. Morgan, Melanie K. O’Rourke, David J. Simon, Nicholas Sinnott Armstrong, Michael C. Bassik, Rebecca J. Shen, Olav Olsen, Trevor R. Mileur, Henry Zebroski, Ross A. Weber, Michael Wainberg, James A. Wells, Angela M. Hitchcock, Marc Tessier-Lavigne, Henrik Molina, Eliza L. Adams, Nicholas T. Hertz
Publikováno v:
Neuron
Summary Selective synaptic and axonal degeneration are critical aspects of both brain development and neurodegenerative disease. Inhibition of caspase signaling in neurons is a potential therapeutic strategy for neurodegenerative disease, but no neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09848c781caaf292a12fe7324925aaa5
https://europepmc.org/articles/PMC8024238/
https://europepmc.org/articles/PMC8024238/
Autor:
Marc Tessier-Lavigne, David J. Simon, Guiping Wang, Deanna M Belsky, Henrik Molina, Melanie K. O’Rourke, Guisheng Zhong, Nicholas T. Hertz, Zhuhao Wu, Xiaowei Zhuang, Evan Heller
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ab4e198f49e323df01b6551df3cfed1
https://doi.org/10.7554/elife.38730.041
https://doi.org/10.7554/elife.38730.041