Výsledky vyhledávání - "Melanie Jokwitz"

Akademický článek

Specificity and Redundancy of Profilin 1 and 2 Function in Brain Development and Neuronal Structure

Autor: Marina Di Domenico, Melanie Jokwitz, Walter Witke, Pietro Pilo Boyl

Publikováno v: Cells, Vol 10, Iss 9, p 2310 (2021)

Profilin functions have been discussed in numerous cellular processes, including actin polymerization. One puzzling aspect is the concomitant expression of more than one profilin isoform in most tissues. In neuronal precursors and in neurons, profili

Externí odkaz: https://doaj.org/article/b8c10b2efb2f4893bc580d2466104304

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Actl7b-deficiency leads to mislocalization of LC8 type dynein light chains and disruption of murine spermatogenesis

Autor: Gina E. Merges, Lena Arévalo, Keerthika Lohanadan, Dirk G. de Rooij, Melanie Jokwitz, Walter Witke, Hubert Schorle

Actin-related proteins (Arp) are classified according to their similarity to actin and are involved in diverse cellular processes.ACTL7Bis a testis-specific Arp and highly conserved in rodents and primates. ACTL7B is specifically expressed in round a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2382f16d78e35d679b8f0796e4c1b85e
https://doi.org/10.1101/2022.12.19.520998

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Specificity and Redundancy of Profilin 1 and 2 Function in Brain Development and Neuronal Structure

Autor: Walter Witke, Pietro Pilo Boyl, Melanie Jokwitz, Marina Di Domenico

Publikováno v: Cells, Vol 10, Iss 2310, p 2310 (2021)
Cells
Volume 10
Issue 9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c52750b0ba7069f3c4678123fb88358
https://doi.org/10.3390/cells10092310

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Severe protein aggregate myopathy in a knockout mouse model points to an essential role of cofilin2 in sarcomeric actin exchange and muscle maintenance

Autor: Christine Chaponnier, Emerald Perlas, Christine B. Gurniak, Walter Witke, Hendrik Richter, Rolf Schröder, Gabi Matern, Pietro Pilo Boyl, Friederike Jönsson, Dieter O. Fürst, Melanie Jokwitz, Frédéric Chevessier

Publikováno v: European Journal of Cell Biology. 93:252-266

Mutations in the human actin depolymerizing factor cofilin2 result in an autosomal dominant form of nemaline myopathy. Here, we report on the targeted ablation of murine cofilin2, which leads to a severe skeletal muscle specific phenotype within the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d7ba229295a9cc23ee06d2543e0ad2
https://doi.org/10.1016/j.ejcb.2014.01.007

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Dual reporter approaches for identification of Cre efficacy and astrocyte heterogeneity

Autor: Christian Steinhäuser, Khalad Karram, Joachim Degen, Martin Theis, Jacqueline Trotter, Klaus Willecke, Pavel Dublin, Melanie Jokwitz, Jiong Zhang, Radoslaw Dobrowolski, Ronald Jabs

Publikováno v: The FASEB Journal; Vol 26

Gene inactivation reporters are powerful tools to circumvent limitations of the widely used Cre/loxP system of conditional mutagenesis. With new conditional transgenic mouse lines expressing the enhanced cyan fluorescent protein (ECFP) instead of con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c383a458d1f7f35a82b85cc1a8b2e02
https://pubmed.ncbi.nlm.nih.gov/22859373

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Connexin32 can restore hearing in connexin26 deficient mice

Autor: Klaus Willecke, Joachim Degen, Nikolai Dicke, Melanie Jokwitz, Nicola Strenzke, Tobias Moser, Melanie Schütz

Publikováno v: European journal of cell biology. 90(10)

Functional gap junction channels composed of certain connexin proteins are essential for the function of the cochlea. Homozygous deficiency in the Gjb2 (mice) or GJB2 (human) gene coding for connexin26 (Cx26) in the cochlea leads to hearing impairmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef023aa9a7993546aa6352370dbc9011
https://pubmed.ncbi.nlm.nih.gov/21813206

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Ablation of gap junctional communication in hepatocytes of transgenic mice does not lead to disrupted cellular homeostasis or increased spontaneous tumourigenesis

Autor: Carina Ittrich, Alessandro Romualdi, Diana Lenhard, Frank Dombrowski, Klaus Willecke, Thomas Ott, Melanie Jokwitz, Michael Schwarz

Publikováno v: European journal of cell biology. 85(8)

Gap junctions between murine hepatocytes are composed of two subunit proteins, connexin26 (Cx26) and connexin32 (Cx32). Previously, we found increased formation of chemically induced liver tumours but no increase in spontaneous development of preneop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aea993cf316b719360bf73ec4f49e0a
https://pubmed.ncbi.nlm.nih.gov/16740338

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Cofilin1 driven actin dynamics controls migration of thymocytes and is essential for positive selection in the thymus

Autor: Friederike Jönsson, Walter Witke, Andree Salz, Christine B. Gurniak

Publikováno v: Journal of Cell Science
Journal of Cell Science, Company of Biologists, 2020, 133 (5), pp.jcs.238048. ⟨10.1242/jcs.238048⟩
Journal of Cell Science, 2020, 133 (5), pp.jcs.238048. ⟨10.1242/jcs.238048⟩

Actin dynamics is essential for T-cell development. We show here that cofilin1 is the key molecule for controlling actin filament turnover in this process. Mice with specific depletion of cofilin1 in thymocytes showed increased steady-state levels of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a553bd9325870af28923c7feaedf4819
https://hal-pasteur.archives-ouvertes.fr/pasteur-02460033/document

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