Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Melanie J. Welham"'
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141401 (2015)
Externí odkaz:
https://doaj.org/article/89028ab86597443fa87cc5365bbb38c1
Autor:
Michael P Storm, Benjamin Kumpfmueller, Heather K Bone, Michael Buchholz, Yolanda Sanchez Ripoll, Julian B Chaudhuri, Hitoshi Niwa, David Tosh, Melanie J Welham
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e89821 (2014)
The Zscan4 family of genes, encoding SCAN-domain and zinc finger-containing proteins, has been implicated in the control of early mammalian embryogenesis as well as the regulation of pluripotency and maintenance of genome integrity in mouse embryonic
Externí odkaz:
https://doaj.org/article/f115cb6f69d24f3da5d9fd63436dc30a
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95434 (2014)
The primitive endoderm arises from the inner cell mass during mammalian pre-implantation development. It faces the blastocoel cavity and later gives rise to the extraembryonic parietal and visceral endoderm. Here, we investigate a key step in primiti
Externí odkaz:
https://doaj.org/article/fe3021379c37404289845d4bfc0d3151
Autor:
Yolanda Sanchez-Ripoll, Heather K Bone, Tom Owen, Ana M V Guedes, Elsa Abranches, Benjamin Kumpfmueller, Ruth V Spriggs, Domingos Henrique, Melanie J Welham
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60148 (2013)
Maintenance of embryonic stem cell (ESC) self-renewal and pluripotency are controlled by extrinsic factors, molecular signaling pathways and transcriptional regulators. While many of the key players have been studied in depth, how the molecular signa
Externí odkaz:
https://doaj.org/article/a9e71f4fc18749b099ef2b8d1780b2e0
Autor:
Luca Orlando, Yolanda Sanchez-Ripoll, James Foster, Heather Bone, Claudia Giachino, Melanie J Welham
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30234 (2012)
The ability to reprogram somatic cells to induced pluripotent stem cells (iPSCs), exhibiting properties similar to those of embryonic stem cells (ESCs), has attracted much attention, with many studies focused on improving efficiency of derivation and
Externí odkaz:
https://doaj.org/article/658f8d33fb684fcb8ee24522d29968c6
Autor:
Herbert Schulz, Raivo Kolde, Priit Adler, Irène Aksoy, Konstantinos Anastassiadis, Michael Bader, Nathalie Billon, Hélène Boeuf, Pierre-Yves Bourillot, Frank Buchholz, Christian Dani, Michael Xavier Doss, Lesley Forrester, Murielle Gitton, Domingos Henrique, Jürgen Hescheler, Heinz Himmelbauer, Norbert Hübner, Efthimia Karantzali, Androniki Kretsovali, Sandra Lubitz, Laurent Pradier, Meena Rai, Jüri Reimand, Alexandra Rolletschek, Agapios Sachinidis, Pierre Savatier, Francis Stewart, Mike P Storm, Marina Trouillas, Jaak Vilo, Melanie J Welham, Johannes Winkler, Anna M Wobus, Antonis K Hatzopoulos, Functional Genomics in Embryonic Stem Cells Consortium
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e6804 (2009)
Embryonic stem (ES) cells have high self-renewal capacity and the potential to differentiate into a large variety of cell types. To investigate gene networks operating in pluripotent ES cells and their derivatives, the "Functional Genomics in Embryon
Externí odkaz:
https://doaj.org/article/a15714b737874268aaa861978cda4038
Autor:
Amanda B. Mackenzie, Sarah Hogg, Melanie J. Welham, Belinda A.N. Thompson, James Hewinson, Michael P. Storm
Publikováno v:
Cellular Signalling
The growth of a pluripotent embryonic stem (ES) cell population is dependent on cell survival, proliferation and self-renewal. The nucleotide ATP represents an important extracellular signalling molecule that regulates the survival of differentiated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac6c62a8b471a01a8bd3ba8bcaa59f51
Publikováno v:
Biotechnology and Bioengineering
Mouse embryonic stem cell (ESC) lines, and more recently human ESC lines, have become valuable tools for studying early mammalian development. Increasing interest in ESCs and their differentiated progeny in drug discovery and as potential therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5c3e222671b3484397e7c4e3ffed19
https://doi.org/10.1002/bit.22850
https://doi.org/10.1002/bit.22850
Autor:
Melanie J. Welham, Emmajayne Kingham
Publikováno v:
Journal of Cell Science. 122:2311-2321
Self-renewal of embryonic stem cells (ESCs) is essential for maintenance of pluripotency, which is defined as the ability to differentiate into any specialised cell type comprising the adult organism. Understanding the mechanisms that regulate ESC se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4155ebd4c5b3d3198104a9fb9c6d34fd
https://doi.org/10.1242/jcs.046557
https://doi.org/10.1242/jcs.046557
Autor:
Arkadiusz Welman, Cristina Martin-Fernandez, Caroline Dive, Cassandra L Hodgkinson, Juliana Bales, Melanie J Welham, Christopher J. Morrow
Publikováno v:
Molecular Cancer Research. 7:955-965
In response to growth factors, class IA phosphoinositide 3-kinases (PI3K) phosphorylate phosphatidylinositol-4,5-bisphosphate, converting it to phosphatidylinositol-3,4,5-trisphosphate to activate protein kinase B/Akt. This is widely reported to prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c722e0991742ea22daed61a8bcc416b7
https://doi.org/10.1158/1541-7786.mcr-08-0445
https://doi.org/10.1158/1541-7786.mcr-08-0445