Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Melanie J. Plastini"'
Autor:
Melanie J. Plastini, Carla Abdelnour, Christina B. Young, Edward N. Wilson, Marian Shahid‐Besanti, Jennifer Lamoureux, Katrin I. Andreasson, Geoffrey A. Kerchner, Thomas J. Montine, Victor W. Henderson, Kathleen L. Poston
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 5, Pp 1197-1210 (2024)
Abstract Objective More than half of neurodegenerative disease patients have multiple pathologies at autopsy; however, most receive one diagnosis during life. We used the α‐synuclein seed amplification assay (αSyn‐SAA) and CSF biomarkers for am
Externí odkaz:
https://doaj.org/article/340d601fd43e42beb69b9417cf089816
Autor:
Melanie J. Plastini, Haritha L. Desu, Maureen C. Ascona, Anna L. Lang, Mario A. Saporta, Roberta Brambilla
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Multiple sclerosis (MS) is the most common neurological disorder in young adults and is classically defined as a chronic inflammatory demyelinating disease of the central nervous system (CNS). Although MS affects millions of people worldwide, its und
Externí odkaz:
https://doaj.org/article/ddd1152b94984375b60a9db4320d69f4
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Microglia play an essential role in maintaining central nervous system (CNS) homeostasis, as well as responding to injury and disease. Most neurological disorders feature microglial activation, a process whereby microglia undergo profound morphologic
Externí odkaz:
https://doaj.org/article/30103bbb6378495b82d02bcc6ca91709
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Mitochondrial DNA fragments are rapidly degraded when double strand breaks occur. Here the authors reveal that the exonuclease activity of polymerase gamma is important for efficient degradation of these fragments and to avoid formation of large dele
Externí odkaz:
https://doaj.org/article/aa5ad2b48a7642f3848faf16ada6efe3
Autor:
Daniel D. Lam, Rhîannan H. Williams, Ernesto Lujan, Koji Tanabe, Georg Huber, Nay Lui Saw, Juliane Merl-Pham, Aaro V. Salminen, David Lohse, Sally Spendiff, Melanie J. Plastini, Michael Zech, Hanns Lochmüller, Arie Geerlof, Stefanie M. Hauck, Mehrdad Shamloo, Marius Wernig, Juliane Winkelmann
Publikováno v:
J Neurosci
J. Neurosci. 42, 1557-1573 (2022)
J. Neurosci. 42, 1557-1573 (2022)
Collagen VI is a key component of muscle basement membranes, and genetic variants can cause monogenic muscular dystrophies. Conversely, human genetic studies recently implicated collagen VI in central nervous system function, with variants causing th
Autor:
Roberta Brambilla, Melanie J. Plastini, Robert W. Keane, Placido Illiano, W. Dalton Dietrich, Haritha L. Desu, Juan Pablo de Rivero Vaccari, Helen M. Bramlett
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-10 (2020)
Desu, H L, Plastini, M, Illiano, P, Bramlett, H M, Dietrich, W D, De Rivero Vaccari, J P, Brambilla, R & Keane, R W 2020, ' IC100 : A novel anti-ASC monoclonal antibody improves functional outcomes in an animal model of multiple sclerosis ', Journal of Neuroinflammation, vol. 17, 143 . https://doi.org/10.1186/s12974-020-01826-0
Journal of Neuroinflammation
Desu, H L, Plastini, M, Illiano, P, Bramlett, H M, Dietrich, W D, De Rivero Vaccari, J P, Brambilla, R & Keane, R W 2020, ' IC100 : A novel anti-ASC monoclonal antibody improves functional outcomes in an animal model of multiple sclerosis ', Journal of Neuroinflammation, vol. 17, 143 . https://doi.org/10.1186/s12974-020-01826-0
Journal of Neuroinflammation
BackgroundThe inflammasome adaptor apoptosis-associated speck-like protein containing a CARD (ASC) is involved in immune signaling by bridging the interactions between inflammasome sensors and caspase-1. Strong experimental evidence has shown that AS
Autor:
Rhîannan H. Williams, Stefanie M. Hauck, David Lohse, Hanns Lochmüller, Nay Lui Saw, Arie Geerlof, Aaro V. Salminen, Juliane Winkelmann, Ernesto Lujan, Sally Spendiff, Marius Wernig, Daniel D. Lam, Mehrdad Shamloo, Georg Huber, Koji Tanabe, Michael Zech, Juliane Merl-Pham, Melanie J. Plastini
Collagen VI is a key component of muscle basement membranes, and genetic variants can cause monogenic muscular dystrophies. Conversely, human genetic studies recently implicated collagen VI in central nervous system function, with variants causing th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::262f0fa37eeb39477175ab9a40fc29ae
https://doi.org/10.1101/2021.09.03.458830
https://doi.org/10.1101/2021.09.03.458830
Autor:
Kristin L Muench, Melanie J. Plastini, Steve S. Ho, Arineh Khechaduri, Julien G Roth, Reenal Pattni, Phillippe Mourrain, Alexander E. Urban, Carol Charlton, Marcus Ho, Louis C. Leung, Bo Zhou, Xianglong Zhang, Joachim Hallmayer, Tom Ward, Theo D. Palmer, Yiling Huang
Copy number variants (CNVs), either deletions or duplications, at the 16p11.2 locus in the human genome are known to increase the risk for autism spectrum disorders (ASD), schizophrenia, and for several other developmental conditions. Here, we invest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bae34ef7a2b4fa16450f2941e4b1985
Autor:
Philippe Mourrain, Theo D. Palmer, Reenal Pattni, Kristin L Muench, Joachim Hallmayer, Louis C. Leung, Alexander E. Urban, Melanie J. Plastini, Ward Thomas, Xianglong Zhang, Marcus Ho, Bo Zhou, Yiling Huang, Steve S. Ho
Publikováno v:
European Neuropsychopharmacology. 29:S66
Autor:
Scott C. Vermilyea, Thaddeus G. Golos, Marcus Ho, Steve S. Ho, Louis C. Leung, Bo Zhou, Marina E. Emborg, Megan A. Albertelli, Melanie J. Plastini, Tom Ward, Dimitri Perrin, Alexander E. Urban, Karen J. Parker, Philippe Mourrain
Publikováno v:
SSRN Electronic Journal.
Due to anatomical and physiological similarities to humans, the common marmoset (Callithrix jacchus) is an ideal organism for the study human diseases. Researchers are currently leveraging genome-editing technologies such as CRISPR/Cas9 to geneticall