Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Melanie J. Mills"'
Autor:
John Lian, Ryan G. Walker, Andrea D’Amico, Ana Vujic, Melanie J. Mills, Kathleen A. Messemer, Kourtney R. Mendello, Jill M. Goldstein, Krystynne A. Leacock, Soraya Epp, Emma V. Stimpfl, Thomas B. Thompson, Amy J. Wagers, Richard T. Lee
Growth differentiation factor 11 (GDF11) and GDF8 (MSTN) are closely related TGFβ family proteins that interact with nearly identical signaling receptors and antagonist proteins. However, GDF11 appears to activate SMAD2/3 in vitro and in vivo more p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::563ca82570f048749642e1a55a4bb43d
Autor:
Samuel J. Wattrus, Miook Cho, Austin Valido, Amy J. Wagers, Kathleen A. Messemer, Paul Besseling, Richard T. Lee, Ryan G. Walker, Melanie J. Mills, Jill M. Goldstein, Kyu Ha Lee, Jordan P. Lewandowski
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-19 (2019)
Scientific Reports
Scientific Reports
Recent advances in CRISPR/Cas gene editing technology have significantly expanded the possibilities and accelerated the pace of creating genetically engineered animal models. However, CRISPR/Cas-based strategies designed to precisely edit the genome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf23623c74443ab125114c1e26986909
http://link.springer.com/article/10.1038/s41598-019-54766-y
http://link.springer.com/article/10.1038/s41598-019-54766-y
Autor:
James R. Pancoast, Yanet Gomez, Colin Marts, Melanie J. Mills, Claudio Macias-Trevino, Kourtney R. Mendello, Hye Lim Noh, Amy J. Wagers, Taekyoon Kim, Jason K. Kim, Francesco S. Loffredo, Ornella Barrandon, Katherine B. LeClair, Tommaso Poggioli, Alexander S. Banks, Richard T. Lee, Shannon H. Carroll, Douglas A. Melton, Sezin Dagdeviren, Ryan G. Walker, David E. Cohen
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Insulin resistance is associated with aging in mice and humans. We have previously shown that administration of recombinant GDF11 (rGDF11) to aged mice alters aging phenotypes in the brain, skeletal muscle, and heart. While the closely related protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4557a828d5807c3af1ea9df3f3fdd7e0
https://pubmed.ncbi.nlm.nih.gov/32165710
https://pubmed.ncbi.nlm.nih.gov/32165710
Autor:
Richard T. Lee, Magdalena Czepnik, Marko Hyvönen, Jason C. McCoy, Craig A. Harrison, Thomas R. Cotton, Melanie J. Mills, Kelly L. Walton, Adam Hagg, Thomas B. Thompson, Ryan G. Walker, Paul Gregorevic
Publikováno v:
Proceedings of the National Academy of Sciences. 115
Growth/differentiation factor 8 (GDF8), or myostatin, negatively regulates muscle mass. GDF8 is held in a latent state through interactions with its N-terminal prodomain, much like TGF-β. Using a combination of small-angle X-ray scattering and mutag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1676d87b93a71d72a2fed82db8ce2aec
https://doi.org/10.1073/pnas.1714622115
https://doi.org/10.1073/pnas.1714622115
Autor:
Craig A. Harrison, Marko Hyvönen, Melanie J. Mills, Ryan G. Walker, Paul Gregorevic, Thomas R. Cotton, Adam Hagg, Thomas B. Thompson, Richard T. Lee, Jason C. McCoy, Kelly L. Walton, Magdalena Czepnik
Growth/differentiation factor 8 (GDF8) or myostatin negatively regulates muscle mass. GDF8 is held in a latent state through interactions with its N-terminal prodomain, much like TGF-β. Using a combination of small angle X-ray scattering and mutagen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d1a1356119f0aadc8c3a8d0418b79c