Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Melanie J Shears"'
Autor:
Souad Amiar, James I MacRae, Damien L Callahan, David Dubois, Giel G van Dooren, Melanie J Shears, Marie-France Cesbron-Delauw, Eric Maréchal, Malcolm J McConville, Geoffrey I McFadden, Yoshiki Yamaryo-Botté, Cyrille Y Botté
Publikováno v:
PLoS Pathogens, Vol 12, Iss 8, p e1005765 (2016)
Most apicomplexan parasites possess a non-photosynthetic plastid (the apicoplast), which harbors enzymes for a number of metabolic pathways, including a prokaryotic type II fatty acid synthesis (FASII) pathway. In Toxoplasma gondii, the causative age
Externí odkaz:
https://doaj.org/article/a6395fe0da554a9fa487e981660cadc4
Autor:
Kristian E Swearingen, Scott E Lindner, Lirong Shi, Melanie J Shears, Anke Harupa, Christine S Hopp, Ashley M Vaughan, Timothy A Springer, Robert L Moritz, Stefan H I Kappe, Photini Sinnis
Publikováno v:
PLoS Pathogens, Vol 12, Iss 4, p e1005606 (2016)
Malaria parasite infection is initiated by the mosquito-transmitted sporozoite stage, a highly motile invasive cell that targets hepatocytes in the liver for infection. A promising approach to developing a malaria vaccine is the use of proteins locat
Externí odkaz:
https://doaj.org/article/36aa7a18455b4b8e8da9ef787afb28cd
Autor:
Felicia N. Watson, Melanie J. Shears, Anya C. Kalata, Caroline J. Duncombe, A. Mariko Seilie, Chris Chavtur, Ethan Conrad, Irene Cruz Talavera, Andrew Raappana, D. Noah Sather, Sumana Chakravarty, B. Kim Lee Sim, Stephen L. Hoffman, Moriya Tsuji, Sean C. Murphy
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Radiation-attenuated sporozoite (RAS) vaccines can completely prevent blood stage Plasmodium infection by inducing liver-resident memory CD8+ T cells to target parasites in the liver. Such T cells can be induced by ‘Prime-and-trap’ vacci
Externí odkaz:
https://doaj.org/article/2b598b8318614ae691922f282846b58b
Autor:
Zachary MacMillen, Kiara Hatzakis, Adrian Simpson, Melanie J. Shears, Felicia Watson, Jesse H. Erasmus, Amit P. Khandhar, Brandon Wilder, Sean C. Murphy, Steven G. Reed, James W. Davie, Marion Avril
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-15 (2024)
Abstract Malaria, caused by Plasmodium parasites, remains one of the most devastating infectious diseases worldwide, despite control efforts to lower morbidity and mortality. Both advanced candidate vaccines, RTS,S and R21, are subunit (SU) vaccines
Externí odkaz:
https://doaj.org/article/9795eb7e6c784cf78f5439f20cf26fbb
Autor:
Gregory J O Martin, David R A Hill, Ian L D Olmstead, Amanda Bergamin, Melanie J Shears, Daniel A Dias, Sandra E Kentish, Peter J Scales, Cyrille Y Botté, Damien L Callahan
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e103389 (2014)
Many species of microalgae produce greatly enhanced amounts of triacylglycerides (TAGs), the key product for biodiesel production, in response to specific environmental stresses. Improvement of TAG production by microalgae through optimization of gro
Externí odkaz:
https://doaj.org/article/4bd97bd0f4d047e6b7a02dfdd55eb538
Autor:
Melanie J. Shears, Rebekah A. Reynolds, Caroline J. Duncombe, Felicia N. Watson, Weston J. Staubus, Chris Chavtur, Annette M. Seilie, Tuan M. Tran, Sumana Chakravarty, Stephen L. Hoffman, Sean C. Murphy
Publikováno v:
Malaria Journal, Vol 22, Iss 1, Pp 1-14 (2023)
Abstract Background Plasmodium knowlesi is an established experimental model for basic and pre-clinical malaria vaccine research. Historically, rhesus macaques have been the most common host for malaria vaccine studies with P. knowlesi parasites. How
Externí odkaz:
https://doaj.org/article/b4459afed9284010b5dba6e4092416a8
Autor:
Naveen Yadav, Chaitra Parthiban, Zachary P. Billman, Brad C. Stone, Felicia N. Watson, Kevin Zhou, Tayla M. Olsen, Irene Cruz Talavera, Annette Mariko Seilie, Anya C. Kalata, Jokichi Matsubara, Melanie J. Shears, Rebekah A. Reynolds, Sean C. Murphy
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108489- (2023)
Summary: Liver stage (LS) Plasmodia mature in 2–2.5 days in rodents compared to 5–6 days in humans. Plasmodium-specific CD8+ T cell expansion differs across these varied timespans. To mimic the kinetics of CD8+ T cells of human Plasmodium infecti
Externí odkaz:
https://doaj.org/article/785bc2f629ce4eeb89ee479e29c9795b
Autor:
Sumana Chakravarty, Melanie J. Shears, Eric R. James, Urvashi Rai, Natasha KC, Solomon Conteh, Lynn E. Lambert, Patrick E. Duffy, Sean C. Murphy, Stephen L. Hoffman
Publikováno v:
Malaria Journal, Vol 21, Iss 1, Pp 1-11 (2022)
Abstract Background Plasmodium falciparum (Pf) sporozoite (SPZ) vaccines are the only candidate malaria vaccines that induce > 90% vaccine efficacy (VE) against controlled human malaria infection and the only malaria vaccines to have achieved reprodu
Externí odkaz:
https://doaj.org/article/4fbb2445f2d24adaba6081405b24db41
Autor:
Felicia N. Watson, Caroline J. Duncombe, Anya C. Kalata, Ethan Conrad, Sumana Chakravarty, B. Kim Lee Sim, Stephen L. Hoffman, Moriya Tsuji, Melanie J. Shears, Sean C. Murphy
Publikováno v:
Biomolecules, Vol 13, Iss 1, p 8 (2022)
7DW8-5 is a potent glycolipid adjuvant that improves malaria vaccine efficacy in mice by inducing IFN-γ and increasing protective CD8+ T cell responses. The addition of 7DW8-5 was previously shown to improve the efficacy of a CD8+ T cell-mediated he
Externí odkaz:
https://doaj.org/article/d5c8442a34024f07a5ad4958a8ce3132
Autor:
Zachary MacMillen, Kiara Hatzakis, Adrian Simpson, Melanie J. Shears, Felicia Watson, Jesse H. Erasmus, Amit P. Khandhar, Brandon Wilder, Sean C. Murphy, Steven G. Reed, James W. Davie, Marion Avril
Publikováno v:
bioRxiv
Malaria, caused byPlasmodiumparasites, remains one of the most devastating infectious diseases worldwide, despite control efforts that have lowered morbidity and mortality. The onlyP. falciparumvaccine candidates to show field efficacy are those targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a4c2339197a779482527ef881a48433
https://doi.org/10.1101/2023.05.23.541932
https://doi.org/10.1101/2023.05.23.541932