Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Melanie J Ludlow"'
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Akademický článek
Endocytosis of HERG is clathrin-independent and involves arf6.
Autor: Rucha Karnik, Melanie J Ludlow, Nada Abuarab, Andrew J Smith, Matthew E L Hardy, David J S Elliott, Asipu Sivaprasadarao
Publikováno v: PLoS ONE, Vol 8, Iss 12, p e85630 (2013)
The hERG potassium channel is critical for repolarisation of the cardiac action potential. Reduced expression of hERG at the plasma membrane, whether caused by hereditary mutations or drugs, results in long QT syndrome and increases the risk of ventr
Externí odkaz: https://doaj.org/article/4b098201bb4e49979d0c500ef772d6d1
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3
Improved PIEZO1 agonism through 4‐benzoic acid modification of Yoda1
Autor: Gregory Parsonage, Kevin Cuthbertson, Naima Endesh, Nicoletta Murciano, Adam J. Hyman, Charlotte H. Revill, Oleksandr V. Povstyan, Eulashini Chuntharpursat‐Bon, Marjolaine Debant, Melanie J. Ludlow, Timothy Simon Futers, Laeticia Lichtenstein, Jacob A. Kinsella, Fiona Bartoli, Maria Giustina Rotordam, Nadine Becker, Andrea Brüggemann, Richard Foster, David J. Beech
Publikováno v: British Journal of Pharmacology.
PIEZO1 forms mechanically activated calcium-permeable non-selective cation channels in numerous species and cell types. Options for pharmacological modulation are limited and so we modified a PIEZO1 small-molecule agonist (Yoda1) to advance capabilit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea43234b6175087acf6ca2bf966f38c
https://doi.org/10.1111/bph.15996
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4
Modeling of full-length Piezo1 suggests importance of the proximal N-terminus for dome structure
Autor: Melanie J. Ludlow, Dario De Vecchis, Adam J. Hyman, Jiehan Chong, Oleksandr V. Povstyan, David J. Beech, Antreas C. Kalli, Jian Shi
Publikováno v: Biophysical Journal. 120:1343-1356
Piezo1 forms a mechanically activated calcium-permeable nonselective cation channel that is functionally important in many cell types. Structural data exist for C-terminal regions, but we lack information about N-terminal regions and how the entire c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55e8a3d159c7241fec33ea3343d75721
https://doi.org/10.1016/j.bpj.2021.02.003
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6
Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion
Autor: Karen E. Porter, Frans A. van Nieuwenhoven, Vasili Stylianidis, Richard Foster, Nicola M Blythe, Neil A. Turner, Katsuhiko Muraki, Jing Li, Hamish T. J. Gilbert, Kevin Cuthbertson, Mark J. Drinkhill, David J. Beech, Elizabeth L. Evans, Joe Swift, Melanie J. Ludlow
Publikováno v: Journal of Biological Chemistry, 294(46), 17395-17408. American Society for Biochemistry and Molecular Biology, Inc.
Blythe, N M, Muraki, K, Ludlow, M J, Stylianidis, V, Gilbert, H T J, Evans, E L, Cuthbertson, K, Foster, R, Swift, J, Li, J, Drinkhill, M J, van Nieuwenhoven, F A, Porter, K E, Beech, D J & Turner, N A 2019, ' Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion ', The Journal of biological chemistry . https://doi.org/10.1074/jbc.RA119.009167
The Journal of Biological Chemistry
Piezo1 is a mechanosensitive cation channel with widespread physiological importance; however, its role in the heart is poorly understood. Cardiac fibroblasts help preserve myocardial integrity and play a key role in regulating its repair and remodel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9105908f59f377a695a247e5ae82f4b9
https://doi.org/10.1074/jbc.ra119.009167
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Potent, selective, and subunit‐dependent activation of TRPC5 channels by a xanthine derivative
Autor: Katsuhiko Muraki, Aisling Minard, David J. Wright, Isabelle B. Pickles, David J. Beech, Robin S. Bon, Claudia C. Bauer, Melanie J. Ludlow, Stuart L. Warriner, Matthew P. Burnham, Eulashini Chuntharpursat-Bon
Publikováno v: British Journal of Pharmacology
Background and purpose The TRPC1, TRPC4, and TRPC5 proteins form homotetrameric or heterotetrameric, calcium-permeable cation channels that are involved in various disease states. Recent research has yielded specific and potent xanthine-based TRPC1/4
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f4e699b9637a2c966805602d09a2869
https://doi.org/10.1111/bph.14791
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8
Genetic variants of PIEZO1 associate with COVID-19 fatality
Autor: Piruthivi Sukumar, Dario De Vecchis, Antreas C. Kalli, Chew Weng Cheng, Melanie J. Ludlow, Vijayalakshmi Deivasikamani, David J. Beech
Fatality from coronavirus disease 19 (COVID-19) is a major problem globally and so identification of its underlying molecular mechanisms would be helpful. The combination of COVID-19 clinical data and genome sequence information is providing a potent
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba6f9b5f8b002c66b8c571477b03b286
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