Výsledky vyhledávání - "Melanie Hornschuh"

Akademický článek

In vitro response of THP-1 derived macrophages to antimicrobially effective PHMB-coated Ti6Al4V alloy implant material with and without contamination with S. epidermidis and P. aeruginosa

Autor: Paula Zwicker, Thomas Schmidt, Melanie Hornschuh, Holger Lode, Axel Kramer, Gerald Müller

Publikováno v: Biomaterials Research, Vol 26, Iss 1, Pp 1-13 (2022)

Abstract Aim Periprosthetic joint infections are a devastating complication after arthroplasty, leading to rejection of the prosthesis. The prevention of septic loosening may be possible by an antimicrobial coating of the implant surface. Poly (hexam

Externí odkaz: https://doaj.org/article/86a353ad513d436388f2890252429833

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Akademický článek

Negative Magnetic Sorting Preserves the Functionality of Ex Vivo Cultivated Non-Adherent Human Monocytes

Autor: Melanie Hornschuh, Vivian Haas, Paul P. Winkel, Mira Y. Gökyildirim, Christina S. Mullins, Ida Maria Wrobel, Christian Manteuffel, Elisa Wirthgen

Publikováno v: Biology, Vol 11, Iss 11, p 1583 (2022)

Background: Monocyte-derived macrophages or dendritic cells are of increasing interest for cellular therapeutic products to treat inflammation-related diseases and cancer. However, the isolation method and the culture conditions applied influence the

Externí odkaz: https://doaj.org/article/014be8d24e0746b9ba12cb6f65783649

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Akademický článek

Mimicking of Blood Flow Results in a Distinct Functional Phenotype in Human Non-Adherent Classical Monocytes

Autor: Elisa Wirthgen, Melanie Hornschuh, Ida Maria Wrobel, Christian Manteuffel, Jan Däbritz

Publikováno v: Biology, Vol 10, Iss 8, p 748 (2021)

Ex vivo culture conditions during the manufacturing process impact the therapeutic effect of cell-based products. Mimicking blood flow during ex vivo culture of monocytes has beneficial effects by preserving their migratory ability. However, the effe

Externí odkaz: https://doaj.org/article/acbe103b1b3549239d685434d5c3ba34

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Poly (hexamethylene biguanide), adsorbed onto Ti‐Al‐V alloys, kills slime‐producing Staphylococci and Pseudomonas aeruginosa without inhibiting SaOs‐2 cell differentiation

Autor: Axel Kramer, Gerald Müller, Paula Zwicker, Melanie Hornschuh, Thomas Schmidt, Birgit Finke

Publikováno v: Journal of Biomedical Materials Research Part B: Applied Biomaterials. 108:1801-1813

Antimicrobial coating of implant material with poly(hexamethylene biguanide) hydrochloride (PHMB) may be an eligible method for preventing implant‐associated infections. In the present study, an antibacterial effective amount of PHMB is adsorbed on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c293b4dd09854406b0787230dc549b25
https://doi.org/10.1002/jbm.b.34522

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In vitro response of THP-1 derived macrophages to antimicrobially effective PHMB-coated Ti6Al4V alloy implant material with and without contamination with S. epidermidis and P. aeruginosa

Autor: Paula Zwicker, Thomas Schmidt, Melanie Hornschuh, Holger Lode, Axel Kramer, Gerald Müller

Publikováno v: Biomaterials Research
Biomaterials Research, Vol 26, Iss 1, Pp 1-13 (2022)

Aim Periprosthetic joint infections are a devastating complication after arthroplasty, leading to rejection of the prosthesis. The prevention of septic loosening may be possible by an antimicrobial coating of the implant surface. Poly (hexamethylene)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f1a6960e548a10ca1a2d94d12b7e80
https://pubmed.ncbi.nlm.nih.gov/35000621

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Extensively-drug-resistant Klebsiella pneumoniae ST307 outbreak strain from north-eastern Germany does not show increased tolerance to quaternary ammonium compounds and chlorhexidine

Autor: Karsten Becker, Katharina Schaufler, Melanie Hornschuh, Jürgen A. Bohnert, Paula Zwicker, Axel Kramer, Nils-Olaf Hübner, Stefan E. Heiden

Publikováno v: The Journal of hospital infection. 113

Summary Background An outbreak of extensively-drug-resistant Klebsiella pneumoniae strain ST307 in a cluster of hospitals in north-east Germany gave rise to the assumption that the epidemiological success of the strain could be based on increased tol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9b52c8bc9493cd5a2d7546c39ae965e
https://pubmed.ncbi.nlm.nih.gov/33587974

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Improved Adsorption of the Antimicrobial Agent Poly (Hexamethylene) Biguanide on Ti-Al-V Alloys by NaOH Treatment and Impact of Mass Coverage and Contamination on Cytocompatibility

Autor: Mihaela Delcea, Melanie Hornschuh, Paula Zwicker, Axel Kramer, Ulrich Lembke, Elisabeth Göbler, Cornelia Prinz, Norman Geist, Thomas Schmidt, Martin Kulke, Gerald Müller

Publikováno v: Coatings, Vol 11, Iss 1118, p 1118 (2021)
Coatings
Volume 11
Issue 9

Unlike the native surface of the implant material (Ti6Al4V), oxidation with H2O2 leads to increased binding of the effective antimicrobial agent poly(hexamethylene) biguanide [PHMB]. However, treating with NaOH instead results in an even higher PHMB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c81b877bf9cb57092e5eb4e527c555
https://doi.org/10.3390/coatings11091118

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In vitro evaluation of contact-active antibacterial efficacy of Ti-Al-V alloys coated with the antimicrobial agent PHMB

Autor: Gerald Müller, Axel Kramer, Paula Zwicker, Melanie Hornschuh, Thomas Schmidt

Publikováno v: Acta biomaterialia. 106

Immobilized polycationic substances on biomaterial surfaces kill adhering bacteria upon contact and are considered a promising non-antibiotic alternative. Unfortunately, there is no generally accepted in vitro method for quantitatively evaluating the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92aec467e934c001c256822ad53c925a
https://pubmed.ncbi.nlm.nih.gov/32068136

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