Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Melanie H. Wong"'
Autor:
Qi Liu, Chien-Hung Chou, Eda Canales, Roman Sakowicz, Steven Bondy, Tomas Cihlar, Albert Liclican, Diana M. Brainard, Anita Niedziela-Majka, William Rowe, Nikolai Novikov, Shekeba Ahmadyar, John R. Somoza, Randall L. Halcomb, Cheryl K. McDonald, Carina E. Cannizzaro, Nicolas Margot, Debi Jin, George Stepan, Qiaoyin Wu, Eric Hu, Judy Mwangi, Stephanie A. Leavitt, Todd C. Appleby, Robert L. Anderson, Scott E. Lazerwith, Schroeder Scott D, Tse Winston C, Gediminas Brizgys, Rebecca Begley, Yili Xu, Scott Sellers, Scott A. Wolckenhauer, Wesley I. Sundquist, Derek Hansen, Philip Morganelli, Andrew Mulato, Sheila Clancy, Xiaohong Liu, Anna Chiu, Eric S. Daar, Renee R. Ram, S. Swaminathan, Anne E. Chester, Melanie H. Wong, Ya-Pei Liu, John O. Link, Michael Graupe, Luong K. Tsai, Christian Callebaut, Latesh Lad, William E. Lee, Rujuta A. Bam, Terrence Z. Cai, Bing Lu, John K. Ling, Roland D. Saito, Magdeleine Hung, Armando G. Villaseñor, Peter Ruane, Nikos Pagratis, Martin S. Rhee, David Koditek, Gordon Crofoot, Giuseppe A. Papalia, Stephen R. Yant, Rob Hyland, Helen Yu, Jim Zheng, Jennifer R. Zhang, Gary I. Sinclair, Jiayao Li, Eric Singer
Publikováno v:
Nature
Oral antiretroviral agents provide life-saving treatments for millions of people living with HIV, and can prevent new infections via pre-exposure prophylaxis1–5. However, some people living with HIV who are heavily treatment-experienced have limite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5892a90808b40581a09439f9529aaaa6
https://doi.org/10.1038/s41586-020-2443-1
https://doi.org/10.1038/s41586-020-2443-1
Autor:
Melanie H Wong, Anita Reddy, Fiona A. Harding, Yoshiko Akamatsu, Marcia Stickler, Paul R. Hinton, Joanna M. Xiong
Publikováno v:
Protein Engineering, Design and Selection. 32:543-554
Humanized and fully human sequence-derived therapeutic antibodies retain the capacity to induce anti-drug antibodies. Daclizumab (humanized version of the murine anti-Tac antibody; E.HAT) was selected for a proof of concept application of engineering
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b97d72c6a57ff96c5eabfe03a0d6b3d9
https://doi.org/10.1093/protein/gzaa017
https://doi.org/10.1093/protein/gzaa017
Autor:
Melanie H. Wong, Helen Yu, Daniel Gonik, Derek Hansen, Wesley I. Sundquist, Debi Jin, Anita Niedziela-Majka, Nikolai Novikov, William M. McDougall, Shekeba Ahmadyar, Albert Liclican, Jill M. Perreira, Andrew Mulato, George Stepan, Jennifer R. Zhang, Bing Lu, Magdeleine Hung, Giuseppe A. Papalia, Renee R. Ram, John O. Link, Kevin Chou, Abraham L. Brass, Eric E. Paoli, Stephen R. Yant, Jim Zheng, Eric Singer, Eric Hu, Tomas Cihlar, Schroeder Scott D, Tse Winston C
Publikováno v:
Nat Med
People living with HIV (PLWH) have expressed concern about the life-long burden and stigma associated with taking pills daily and can experience medication fatigue that might lead to suboptimal treatment adherence and the emergence of drug-resistant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::283229e5414364737d5a0814370ed2fa
https://doi.org/10.1038/s41591-019-0560-x
https://doi.org/10.1038/s41591-019-0560-x
Autor:
Jiri Vlach, Alexandra B. Samal, Anita Niedziela-Majka, Michael V. Lee, Giuseppe A. Papalia, Melanie H. Wong, Katherine M. Brendza, Brian E. Schultz, Dmitry O. Koltun, Hyock Joo Kwon, Joy Y. Feng, Roman Sakowicz, Nikolai Novikov, Jamil S. Saad
Publikováno v:
Journal of Molecular Biology. 431:1440-1459
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine protein kinase that transmits calcium signals in various cellular processes. CaMKII is activated by calcium-bound calmodulin (Ca2+/CaM) through a direct bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66ee4acd312eda128004cfb016e9d735
https://doi.org/10.1016/j.jmb.2019.02.001
https://doi.org/10.1016/j.jmb.2019.02.001
Autor:
David G. Breckenridge, Laurie A. Castonguay, Giuseppe A. Papalia, Swetha Pendem, Shawn S. Badal, Ford Hinojosa-Kirschenbaum, Gregory T. Notte, Sarah Wise, Michael V. Lee, Keith A. Koch, Agnes B. Fogo, Dorothy French, Britton Kenneth Corkey, Frank Y. Ma, Brian E. Schultz, Eric B. Lansdon, Melanie H. Wong, David J. Nikolic-Paterson, Tareq M Al-Tuhaifi, Theodore Sullivan, Michael Graupe, Haichun Yang, Erik Huntzicker, Grant R. Budas, John T. Liles
Publikováno v:
Journal of Clinical Investigation. 128:4485-4500
Oxidative stress is an underlying component of acute and chronic kidney disease. Apoptosis signal–regulating kinase 1 (ASK1) is a widely expressed redox-sensitive serine threonine kinase that activates p38 and c-Jun N-terminal kinase (JNK) mitogen-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b037ace289b522c4f72e5fa892d048
https://doi.org/10.1172/jci99768
https://doi.org/10.1172/jci99768
Autor:
Yu-Jen Lee, Andrew John Keats, Karine G. Poullennec, Uli Schmitz, Todd C. Appleby, Hans G. Fliri, Linos Lazarides, Albert Liclican, Steven J. Stanway, David Kenneth Dean, Debi Jin, Victoria Alexandra Steadman, Simon B. Pettit, Stephanie A. Leavitt, Yang Tian, Jonathan Sanvoisin, Petr Jansa, Brian E. Schultz, Christian R. Frey, Melanie H. Wong, Gregory M. Watt, Richard L. Mackman, Carol Austin
Publikováno v:
Journal of Medicinal Chemistry. 60:1000-1017
Cyclophilin inhibition has been a target for the treatment of hepatitis C and other diseases, but the generation of potent, drug-like molecules through chemical synthesis has been challenging. In this study, a set of macrocyclic cyclophilin inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::091df6df2743a293d5a795f54f7981a6
https://doi.org/10.1021/acs.jmedchem.6b01329
https://doi.org/10.1021/acs.jmedchem.6b01329
Autor:
Melanie H, Wong, Alexandra B, Samal, Mike, Lee, Jiri, Vlach, Nikolai, Novikov, Anita, Niedziela-Majka, Joy Y, Feng, Dmitry O, Koltun, Katherine M, Brendza, Hyock Joo, Kwon, Brian E, Schultz, Roman, Sakowicz, Jamil S, Saad, Giuseppe A, Papalia
Publikováno v:
Journal of molecular biology. 431(7)
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine protein kinase that transmits calcium signals in various cellular processes. CaMKII is activated by calcium-bound calmodulin (Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8c365e701f74cb06093bfe3e0454bce1
https://pubmed.ncbi.nlm.nih.gov/30753871
https://pubmed.ncbi.nlm.nih.gov/30753871
Autor:
Anita Niedziela-Majka, Chien-Hung Chou, Eric Hu, Tse Winston C, David Koditek, Debi Jin, Latesh Lad, Magdeleine Hung, Nikos Pagratis, Stephen R. Yant, Sheila Clancy, Melanie H. Wong, Randall L. Halcomb, John R. Somoza, Roman Sakowicz, Giuseppe A. Papalia
Publikováno v:
Biochemistry. 54:2240-2248
HIV capsid protein is an important target for antiviral drug design. High-throughput screening campaigns have identified two classes of compounds (PF74 and BI64) that directly target HIV capsid, resulting in antiviral activity against HIV-1 and HIV-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d0ca08e50cd957c4a523fb653c9395
https://doi.org/10.1021/acs.biochem.5b00151
https://doi.org/10.1021/acs.biochem.5b00151
Autor:
Dharmaraj Samuel, John R. Somoza, Ruth Wang, Albert Liclican, Armando G. Villaseñor, Nikolai Novikov, Leanna Lagpacan, Giuseppe A. Papalia, Mary E. McGrath, Latesh Lad, David Koditek, Brian E. Schultz, Melanie H. Wong, Weimei Xing
Publikováno v:
The Journal of Biological Chemistry
Background: Idelalisib is a PI3Kδ inhibitor used to treat hematological malignancies. Results: Idelalisib is selective, noncovalent, reversible, and ATP-competitive. Conclusion: The crystal structure helps explain the potency and selectivity of idel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b59c0a1823cbc8e9c815636bff638c1
http://europepmc.org/articles/PMC4375495
http://europepmc.org/articles/PMC4375495
Autor:
Todd C. Appleby, Ruth Wang, Magdeleine Hung, Brian E. Schultz, Roman Sakowicz, Armando G. Villaseñor, Giuseppe A. Papalia, Maile Velasquez, Xiaohong Liu, Victoria C. Smith, Andrew E. Greenstein, Hyock Joo Kwon, Melanie H. Wong, Albert Liclican
Publikováno v:
The Journal of biological chemistry. 292(16)
Matrix metalloproteinase 9 (MMP9) is a member of a large family of proteases that are secreted as inactive zymogens. It is a key regulator of the extracellular matrix, involved in the degradation of various extracellular matrix proteins. MMP9 plays a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9f99c41e438cdd9e0534167e54a63aa
https://pubmed.ncbi.nlm.nih.gov/28235803
https://pubmed.ncbi.nlm.nih.gov/28235803