Zobrazeno 1 - 10
of 482
pro vyhledávání: '"Melanie H Cobb"'
Autor:
Wang Yuan, Yi M. Weaver, Svetlana Earnest, Clinton A. Taylor, Melanie H. Cobb, Benjamin P. Weaver
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The conserved p38 MAPK family is activated by phosphorylation during stress responses and inactivated by phosphatases. C. elegans PMK-1 p38 MAPK initiates innate immune responses and blocks development when hyperactivated. Here we show that
Externí odkaz:
https://doaj.org/article/cb50195b62e840468d6c3a22506f3b03
Autor:
Michael A. Kalwat, Karina Rodrigues-dos-Santos, Derk D. Binns, Shuguang Wei, Anwu Zhou, Matthew R. Evans, Bruce A. Posner, Michael G. Roth, Melanie H. Cobb
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
PurposeType 1 diabetes (T1D) accounts for an estimated 5% of all diabetes in the United States, afflicting over 1.25 million individuals. Maintaining long-term blood glucose control is the major goal for individuals with T1D. In T1D, insulin-secretin
Externí odkaz:
https://doaj.org/article/5b86bc5e2aad4d56b25d4ff17c19aa48
Autor:
Ana Martin-Vega, Melanie H. Cobb
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1555 (2023)
The RAS-ERK pathway is a fundamental signaling cascade crucial for many biological processes including proliferation, cell cycle control, growth, and survival; common across all cell types. Notably, ERK1/2 are implicated in specific processes in a co
Externí odkaz:
https://doaj.org/article/c0b4012c17374b3199887710ab3986e5
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Metastasis is the major cause of mortality in cancer patients. Analyses of mouse models and patient data have implicated the protein kinase WNK1 as one of a handful of genes uniquely linked to a subset of invasive cancers. WNK1 signaling pathways are
Externí odkaz:
https://doaj.org/article/1928326a99e84ee383f1ab3bbee86022
Autor:
Xu-Dong Wang, Rongkuan Hu, Qing Ding, Trisha K. Savage, Kenneth E. Huffman, Noelle Williams, Melanie H. Cobb, John D. Minna, Jane E. Johnson, Yonghao Yu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Secreted proteins present a rich resource of potential cancer biomarkers. Here, the authors use mass spectrometry to analyze secretome remodeling in pulmonary neuroendocrine lung cancer cell lines and validate potential biomarkers and therapeutic tar
Externí odkaz:
https://doaj.org/article/ab493e2c25ce4d6f9e28ead2e5b28542
Autor:
Clinton A. Taylor, Kevin W. Cormier, Ana Martin-Vega, Svetlana Earnest, Steve Stippec, Chonlarat Wichaidit, Melanie H. Cobb
Publikováno v:
Biochemistry. 62:1433-1442
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f0b01fe527d640dad87a2f746930e94
https://doi.org/10.1021/acs.biochem.3c00044
https://doi.org/10.1021/acs.biochem.3c00044
Autor:
Zhenan Liu, Joonho Yoon, Chonlarat Wichaidit, Ankita B. Jaykumar, Hashem A. Dbouk, Addie E. Embry, Liping Liu, Joel M. Henderson, Audrey N. Chang, Melanie H. Cobb, Richard Tyler Miller
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Cytoskeletal structure and its regulation are essential for maintenance of the differentiated state of specific types of cells and their adaptation to physiologic and pathophysiologic conditions. Renal glomerular capillaries, composed of podocytes, e
Externí odkaz:
https://doaj.org/article/574eb57a64854f5b92b6fd2734e682dd
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Adrenergic signaling is a well-known input into pancreatic islet function. Specifically, the insulin-secreting islet β cell expresses the Gi/o-linked α2-adrenergic receptor, which upon activation suppresses insulin secretion. The use of the adrener
Externí odkaz:
https://doaj.org/article/f868a0e8bb7041c78de027e08bd22ff0
Publikováno v:
Cell Communication and Signaling, Vol 16, Iss 1, Pp 1-6 (2018)
Abstract Background The with no lysine [K] (WNK) pathway consists of the structurally unique WNK kinases, their downstream target kinases, oxidative stress responsive (OSR)1 and SPS/Ste20-related proline-alanine-rich kinase (SPAK), and a multitude of
Externí odkaz:
https://doaj.org/article/f0aa27ce45f94c01b85267eab922a679
Autor:
Min He, Shanshan Liu, Sachith Gallolu Kankanamalage, Mark D. Borromeo, Luc Girard, Adi F. Gazdar, John D. Minna, Jane E. Johnson, Melanie H. Cobb
Publikováno v:
Translational Oncology, Vol 11, Iss 2, Pp 292-299 (2018)
Small cell lung cancer (SCLC) is an aggressive neuroendocrine carcinoma, designated as a recalcitrant cancer by the National Cancer Institute, in urgent need of new rational therapeutic targets. Previous studies have determined that the basic helix-l
Externí odkaz:
https://doaj.org/article/1defee1706d14f1d999e8f2802d42433