Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Melanie Gubbels Bupp"'
Publikováno v:
The Journal of Immunology. 206:11.17-11.17
Previous work suggests that glucocorticoids upregulate expression of CD127, an IL-7 receptor component, on peripheral naïve T cells (NT), even though the total number of peripheral NT declines dramatically during malnourishment. We proposed that CD1
Autor:
Mohammed Javeed I. Ansari, Paolo Fiorina, Nidyanandh Vadivel, Shirine Dada, Brian T. Fife, Qizhi Tang, Hideo Yagita, Miyuki Azuma, Mark A. Atkinson, Subbulaxmi Trikudanathan, Indira Guleria, Melanie Gubbels Bupp, Jeffrey A. Bluestone, Mohamed H. Sayegh
Publikováno v:
Clinical Immunology. 125:16-25
The PD-1-PDL1 pathway plays a critical role in regulating autoimmune diabetes as blockade or deficiency of PD-1 or PDL1 results in accelerated disease in NOD mice. We explored the cellular mechanisms involved in the regulation of these autoimmune res
Autor:
Qizhi Tang, Shirine Dada, Melanie Gubbels Bupp, Mohamed H. Sayegh, Jeffrey A. Bluestone, Mohammed Javeed I. Ansari, Nidyanandh Vadivel, Indira Guleria, Subbulaxmi Trikudanathan, Mark A. Atkinson, Brian T. Fife, Paolo Fiorina, Miyuki Azuma, Hideo Yagita
Publikováno v:
Clinical Immunology, vol 150, iss 1
Guleria, I; Bupp, MG; Dada, S; Fife, BT; Tang, Q; Ansari, MJ; et al.(2014). Corrigendum to 'Mechanisms of PDL1-mediated regulation of autoimmune diabetes' [Clin. Immunol. 125 (2007) 16-25]. Clinical Immunology, 150(1), 134. doi: 10.1016/j.clim.2013.09.004. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/4qp8p834
Guleria, I; Bupp, MG; Dada, S; Fife, BT; Tang, Q; Ansari, MJ; et al.(2014). Corrigendum to 'Mechanisms of PDL1-mediated regulation of autoimmune diabetes' [Clin. Immunol. 125 (2007) 16-25]. Clinical Immunology, 150(1), 134. doi: 10.1016/j.clim.2013.09.004. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/4qp8p834
Mechanisms of PDL1-Mediated Regulation of Autoimmune Diabetes Indira Guleria 1✝ , Melanie Gubbels Bupp 2✝ , Shirine Dada 1 , Brian Fife 2 , Qizhi Tang 2 , Mohammed Javeed Ansari 1 , Subbulaxmi Trikudanathan 1, Nidyanandh Vadivel 1 , Paolo Fiorina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b61269e536a5707f04e72ffa2752400c
https://escholarship.org/uc/item/4qp8p834
https://escholarship.org/uc/item/4qp8p834
Increased expression of IFN-inducible Ifi202 gene in certain strains of female mice is associated with susceptibility to systemic lupus erythematosus (SLE). Although, the development of SLE is known to have a strong sex bias, the molecular mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3b3fa19df052f352ca15a21d9feff4
https://europepmc.org/articles/PMC2783550/
https://europepmc.org/articles/PMC2783550/
Autor:
Bonnie Edwards, Caiying Guo, Stanford L. Peng, Datsen Wei, Gang Chen, Brian Wong, Melanie Gubbels Bupp, Emma Masteller
Publikováno v:
European journal of immunology. 39(11)
Forkhead transcription factors play critical roles in leukocyte homeostasis. To study further the immunological functions of Foxo1, we generated mice that selectively lack Foxo1 in T cells (Foxo1(flox/flox) Lck.cre(+)conditional knockout mice (cKO)).
Publikováno v:
The Journal of Immunology. 194:62.8-62.8
T cell homeostasis is clearly disrupted by malnutrition, but the precise cues and mechanisms through which it occurs are unknown. Short-term malnutrition reduces the size of the peripheral CD8+ T population in mice. Perhaps paradoxically, malnourishe
Autor:
Hideo Yagita, Miyuki Azuma, Indira Guleria, Brian T. Fife, Jeffrey A. Bluestone, Qizhi Tang, Todd N. Eagar, Hélène Bour-Jordan, Melanie Gubbels Bupp, Mohamed H. Sayegh
Publikováno v:
The Journal of experimental medicine, vol 203, iss 12
The Journal of Experimental Medicine
The Journal of Experimental Medicine
The past decade has seen a significant increase in the number of potentially tolerogenic therapies for treatment of new-onset diabetes. However, most treatments are antigen nonspecific, and the mechanism for the maintenance of long-term tolerance rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::079de0870c0b0eabb59fe1c3e36adb99
https://escholarship.org/uc/item/36d0w1zf
https://escholarship.org/uc/item/36d0w1zf
Autor:
Melanie Gubbels Bupp, Seth Litvin, R. Edwards, Brittany Mihalcoe, Frances Byrne, Kyle Hoehn, Joshua Anoff
Publikováno v:
The Journal of Immunology. 192:65.15-65.15
The naïve CD8+ T cell population must be large enough so that sufficient diversity exists to respond to potential pathogens, yet not so large as to unnecessarily drain an organism’s resources. Thus, we propose that a molecular network links the si
Autor:
Melanie Gubbels Bupp, Stanford L. Peng
Publikováno v:
Clinical Immunology. 123:S118-S119
Publikováno v:
The Journal of Immunology. 190:119.5-119.5
In addition to longevity enhancement, calorie restriction has been reported to slow the appearance of aging-related T cell abnormalities. However, the molecular mechanism underlying this phenomenon is ill-defined. We report that short-term calorie re