Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Melanie Grusdat"'
Autor:
Leticia Soriano-Baguet, Melanie Grusdat, Henry Kurniawan, Mohaned Benzarti, Carole Binsfeld, Anouk Ewen, Joseph Longworth, Lynn Bonetti, Luana Guerra, Davide G. Franchina, Takumi Kobayashi, Veronika Horkova, Charlène Verschueren, Sergio Helgueta, Deborah Gérard, Tushar H. More, Antonia Henne, Catherine Dostert, Sophie Farinelle, Antoine Lesur, Jean-Jacques Gérardy, Christian Jäger, Michel Mittelbronn, Lasse Sinkkonen, Karsten Hiller, Johannes Meiser, Dirk Brenner
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112153- (2023)
Summary: Pyruvate dehydrogenase (PDH) is the central enzyme connecting glycolysis and the tricarboxylic acid (TCA) cycle. The importance of PDH function in T helper 17 (Th17) cells still remains to be studied. Here, we show that PDH is essential for
Externí odkaz:
https://doaj.org/article/4c586aa5408c4295a1eead933ab65a54
Autor:
Davide G. Franchina, Henry Kurniawan, Melanie Grusdat, Carole Binsfeld, Luana Guerra, Lynn Bonetti, Leticia Soriano-Baguet, Anouk Ewen, Takumi Kobayashi, Sophie Farinelle, Anna Rita Minafra, Niels Vandamme, Anaïs Carpentier, Felix K. Borgmann, Christian Jäger, Ying Chen, Markus Kleinewietfeld, Vasilis Vasiliou, Michel Mittelbronn, Karsten Hiller, Philipp A. Lang, Dirk Brenner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Follicular and marginal zone B (FoB and MZB, respectively) cells have divergent metabolic characteristics. Here the authors show that deficiency of glutamate cysteine ligase (Gclc), the enzyme for glutathione synthesis, differentially impacts FoB and
Externí odkaz:
https://doaj.org/article/82e7256382b44500933f4d48afe4151d
Autor:
Christina Lückel, Felix Picard, Hartmann Raifer, Lucia Campos Carrascosa, Anna Guralnik, Yajuan Zhang, Matthias Klein, Stefan Bittner, Falk Steffen, Sonja Moos, Federico Marini, Renee Gloury, Florian C. Kurschus, Ying-Yin Chao, Wilhelm Bertrams, Veronika Sexl, Bernd Schmeck, Lynn Bonetti, Melanie Grusdat, Michael Lohoff, Christina E. Zielinski, Frauke Zipp, Axel Kallies, Dirk Brenner, Michael Berger, Tobias Bopp, Björn Tackenberg, Magdalena Huber
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Dimethyl fumarate (DMF) is a therapy for multiple sclerosis (MS) with undetermined mechanism of action. Here the authors find that clinical response to DMF associates with decrease in IL-17-producing CD8+ T cells (Tc17), delineate molecular pathways
Externí odkaz:
https://doaj.org/article/2e2f0c2356834c5db881aabfe09b997c
Autor:
Philipp A. Lang, Sarah Q. Crome, Haifeng C. Xu, Karl S. Lang, Laurence Chapatte, Elissa K. Deenick, Melanie Grusdat, Aleksandra A. Pandyra, Vitaly I. Pozdeev, Ruifeng Wang, Tobias A. W. Holderried, Harvey Cantor, Andreas Diefenbach, Alisha R. Elford, David R. McIlwain, Mike Recher, Dieter Häussinger, Tak W. Mak, Pamela S. Ohashi
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Elucidating key factors that regulate immune-mediated pathology in vivo is critical for developing improved strategies to treat autoimmune disease and cancer. NK cells can exhibit regulatory functions against CD8+ T cells following viral infection. H
Externí odkaz:
https://doaj.org/article/c6d755c74d6340298648772ef2029098
Autor:
Samadhi Aparicio-Siegmund, Jens M Moll, Juliane Lokau, Melanie Grusdat, Jutta Schröder, Svenja Plöhn, Stefan Rose-John, Joachim Grötzinger, Philipp A Lang, Jürgen Scheller, Christoph Garbers
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107990 (2014)
The Interleukin (IL)-12 family contains several heterodimeric composite cytokines which share subunits among each other. IL-12 consists of the subunits p40 (shared with IL-23) and p35. p35 is shared with the composite cytokine IL-35 which comprises o
Externí odkaz:
https://doaj.org/article/7d352694791944468e1405fbb89ef5cf
Autor:
Wei He, Antonia Henne, Mario Lauterbach, Eike Geißmar, Fabian Nikolka, Celia Kho, Alexander Heinz, Catherine Dostert, Melanie Grusdat, Thekla Cordes, Janika Härm, Oliver Goldmann, Anouk Ewen, Charlène Verschueren, Julia Blay-Cadanet, Robert Geffers, Hendrikus Garritsen, Manfred Kneiling, Christian K. Holm, Christian M. Metallo, Eva Medina, Zeinab Abdullah, Eicke Latz, Dirk Brenner, Karsten Hiller
Publikováno v:
He, W, Henne, A, Lauterbach, M, Geißmar, E, Nikolka, F, Kho, C, Heinz, A, Dostert, C, Grusdat, M, Cordes, T, Härm, J, Goldmann, O, Ewen, A, Verschueren, C, Blay-Cadanet, J, Geffers, R, Garritsen, H, Kneiling, M, Holm, C K, Metallo, C M, Medina, E, Abdullah, Z, Latz, E, Brenner, D & Hiller, K 2022, ' Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages ', Nature Metabolism, vol. 4, pp. 524-533 . https://doi.org/10.1038/s42255-022-00565-1
Nat Metab
Nature metabolism 4(5), 524-533 (2022). doi:10.1038/s42255-022-00565-1
Nat Metab
Nature metabolism 4(5), 524-533 (2022). doi:10.1038/s42255-022-00565-1
Since its discovery in inflammatory macrophages, itaconate has attracted much attention due to its antimicrobial and immunomodulatory activity1–3. However, instead of investigating itaconate itself, most studies used derivatized forms of itaconate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86da36f6721a8c5d31039c1087b6fffe
https://pure.au.dk/portal/da/publications/mesaconate-is-synthesized-from-itaconate-and-exerts-immunomodulatory-effects-in-macrophages(388abbbf-b0fa-47be-95bb-1425efc844aa).html
https://pure.au.dk/portal/da/publications/mesaconate-is-synthesized-from-itaconate-and-exerts-immunomodulatory-effects-in-macrophages(388abbbf-b0fa-47be-95bb-1425efc844aa).html
Autor:
Nicole Paczia, C. Leonard, Mark A. Gillespie, Wolfgang Wurst, Carole L. Linster, Christophe Capelle, Markus Ollert, Melanie Grusdat, Feng He, Balling R, C. Guerin, Dirk Brenner, S. Delhalle, Daniela Vogt-Weisenhorn, Jens Christian Schwamborn, O. Domingues, Jeffrey A. Ranish, Henry Kurniawan, Rejko Krueger, Djalil Coowar, Davide G. Franchina, Alexandre Baron, Ni Zeng, Gemma Gomez-Giro, Egle Danileviciute
Pyruvate dehydrogenase (PDH) is the gatekeeper enzyme into the tricarboxylic acid (TCA) cycle. Here we show that PARK7/DJ-1, a key familial Parkinson’s disease (PD) gene, is a pacemaker controlling PDH activity in CD4 regulatory T cells (Tregs). DJ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5fefb51be330c9190d105ea1c39ca8f
https://doi.org/10.1101/2019.12.20.884809
https://doi.org/10.1101/2019.12.20.884809
Autor:
Egle, Danileviciute, Ni, Zeng, Christophe M, Capelle, Nicole, Paczia, Mark A, Gillespie, Henry, Kurniawan, Mohaned, Benzarti, Myriam P, Merz, Djalil, Coowar, Sabrina, Fritah, Daniela Maria, Vogt Weisenhorn, Gemma, Gomez Giro, Melanie, Grusdat, Alexandre, Baron, Coralie, Guerin, Davide G, Franchina, Cathy, Léonard, Olivia, Domingues, Sylvie, Delhalle, Wolfgang, Wurst, Jonathan D, Turner, Jens Christian, Schwamborn, Johannes, Meiser, Rejko, Krüger, Jeff, Ranish, Dirk, Brenner, Carole L, Linster, Rudi, Balling, Markus, Ollert, Feng Q, Hefeng
Publikováno v:
Nature metabolism. 4(5)
Pyruvate dehydrogenase (PDH) is the gatekeeper enzyme of the tricarboxylic acid (TCA) cycle. Here we show that the deglycase DJ-1 (encoded by PARK7, a key familial Parkinson's disease gene) is a pacemaker regulating PDH activity in CD4
Autor:
Christina, Lückel, Felix, Picard, Hartmann, Raifer, Lucia, Campos Carrascosa, Anna, Guralnik, Yajuan, Zhang, Matthias, Klein, Stefan, Bittner, Falk, Steffen, Sonja, Moos, Federico, Marini, Renee, Gloury, Florian C, Kurschus, Ying-Yin, Chao, Wilhelm, Bertrams, Veronika, Sexl, Bernd, Schmeck, Lynn, Bonetti, Melanie, Grusdat, Michael, Lohoff, Christina E, Zielinski, Frauke, Zipp, Axel, Kallies, Dirk, Brenner, Michael, Berger, Tobias, Bopp, Björn, Tackenberg, Magdalena, Huber
Publikováno v:
Nature Communications
IL-17-producing CD8+ (Tc17) cells are enriched in active lesions of patients with multiple sclerosis (MS), suggesting a role in the pathogenesis of autoimmunity. Here we show that amelioration of MS by dimethyl fumarate (DMF), a mechanistically elusi
Autor:
Melanie Grusdat, Ying Chen, Dennis Das Gupta, Tak W. Mak, Rashi Halder, Sophie Farinelle, Christian Jäger, Johannes Meiser, Luana Guerra, Lynn Bonetti, Gordon S. Duncan, Anouk Ewen, Lisa Schlicker, Paul Wilmes, Karsten Hiller, Jillian Haight, Myriam P. Merz, Yannic Nonnenmacher, Michael Lohoff, Rabia Taskesen, Vasilis Vasiliou, Markus Ollert, Davide G. Franchina, Carole Binsfeld, Isaac S. Harris, Christiane B. Knobbe-Thomsen, Oliver Hunewald, Henry Kurniawan, Dirk Brenner, Jonathan D. Turner, Leticia Soriano Baguet, Catherine Dostert
Publikováno v:
Cell Metab
936.e7
Cell metabolism
United States
Kurniawan, H, Franchina, D G, Guerra, L, Bonetti, L, Baguet, L S, Grusdat, M, Schlicker, L, Hunewald, O, Dostert, C, Merz, M P, Binsfeld, C, Duncan, G S, Farinelle, S, Nonnenmacher, Y, Haight, J, Das Gupta, D, Ewen, A, Taskesen, R, Halder, R, Chen, Y, Jäger, C, Ollert, M, Wilmes, P, Vasiliou, V, Harris, I S, Knobbe-Thomsen, C B, Turner, J D, Mak, T W, Lohoff, M, Meiser, J, Hiller, K & Brenner, D 2020, ' Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function ', Cell Metabolism, vol. 31, no. 5, pp. 920-936.e7 . https://doi.org/10.1016/j.cmet.2020.03.004
936.e7
Cell metabolism
United States
Kurniawan, H, Franchina, D G, Guerra, L, Bonetti, L, Baguet, L S, Grusdat, M, Schlicker, L, Hunewald, O, Dostert, C, Merz, M P, Binsfeld, C, Duncan, G S, Farinelle, S, Nonnenmacher, Y, Haight, J, Das Gupta, D, Ewen, A, Taskesen, R, Halder, R, Chen, Y, Jäger, C, Ollert, M, Wilmes, P, Vasiliou, V, Harris, I S, Knobbe-Thomsen, C B, Turner, J D, Mak, T W, Lohoff, M, Meiser, J, Hiller, K & Brenner, D 2020, ' Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function ', Cell Metabolism, vol. 31, no. 5, pp. 920-936.e7 . https://doi.org/10.1016/j.cmet.2020.03.004
Regulatory T cells (Tregs) maintain immune homeostasis and prevent autoimmunity. Serine stimulates glutathione (GSH) synthesis and feeds into the one-carbon metabolic network (1CMet) essential for effector T cell (Teff) responses. However, serine's f