Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Melanie Grimm"'
Autor:
Elisabeth Panther, Thorsten Dürk, Davide Ferrari, Francesco Di Virgilio, Melanie Grimm, Stephan Sorichter, Sanja Cicko, Yared Herouy, Johannes Norgauer, Marco Idzko, Tobias Müller
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37560 (2012)
The nucleotide adenosine-5'-monophosphate (AMP) can be released by various cell types and has been shown to elicit different cellular responses. In the extracellular space AMP is dephosphorylated to the nucleoside adenosine which can then bind to ade
Externí odkaz:
https://doaj.org/article/b3818f1d2fb742678211a8fe59bdaffc
Autor:
Tobias Müller, Thorsten Dürk, Britta Blumenthal, Melanie Grimm, Sanja Cicko, Elisabeth Panther, Stephan Sorichter, Yared Herouy, Francesco Di Virgilio, Davide Ferrari, Johannes Norgauer, Marco Idzko
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6453 (2009)
Beside its well described role in the central and peripheral nervous system 5-hydroxytryptamine (5-HT), commonly known as serotonin, is also a potent immuno-modulator. Serotoninergic receptors (5-HTR) are expressed by a broad range of inflammatory ce
Externí odkaz:
https://doaj.org/article/15ccb39dbbe043fdb76826ac1dac2ca3
Autor:
Pavel Klener, Klaus Schulze-Osthoff, Karsten Boldt, Philipp Berning, Martina Konantz, Michael Grau, Georg Lenz, Caroline Schönfeld, Wendan Xu, Philip Bucher, Petra Vockova, Mohamed Ali Jarboui, Anja Schmitt, Andreas Rosenwald, German Ott, Melanie Grimm, Claudia Lengerke, Marc Brändle, Heike Horn, Stephan Hailfinger, Myroslav Zapukhlyak
Publikováno v:
Blood. 138:871-884
Despite the development of novel targeted drugs, the molecular heterogeneity of diffuse large B-cell lymphoma (DLBCL) still poses a substantial therapeutic challenge. DLBCL can be classified into at least 2 major subtypes (germinal center B cell [GCB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71790a932be7618d1a2c827477d0e894
https://doi.org/10.1182/blood.2020009404
https://doi.org/10.1182/blood.2020009404
Autor:
Daniel, Stehle, Melanie, Grimm, Stephanie, Einsele-Scholz, Friederike, Ladwig, Janina, Johänning, Gerd, Fischer, Bernhard, Gillissen, Klaus, Schulze-Osthoff, Frank, Essmann
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports
Scientific Reports
Central to intrinsic apoptosis signaling is the release of cytochrome c from mitochondria, which depends on the pro-apoptotic effector proteins Bax, Bak or Bok. These pore-forming effector proteins share four Bcl-2 homology (BH) domains, a functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5bff4e82db6beea376b4665fd8dcad10
http://link.springer.com/article/10.1038/s41598-018-30603-6
http://link.springer.com/article/10.1038/s41598-018-30603-6
Autor:
Adilson Santos Andrade-Sousa, Tobias Müller, Rodolfo de Paula Vieira, Manoel Carneiro Oliveira-Junior, Sanja Cicko, Adriano Silva-Renno, Maysa Alves Rodrigues Brandão-Rangel, Melanie Grimm, Alana Santos-Dias, BreAnne MacKenzie, Milton A. Martins, Erasmo Assumpção-Neto, Marco Idzko, Ana Paula Ligeiro Oliveira
Publikováno v:
Medicine & Science in Sports & Exercise. 48:1459-1467
This study investigated the effects of aerobic exercise (AE) on both the maturation of dendritic cells (DC) and the activation of lymphocytes in a mouse model of chronic allergic airway inflammation.C57BL/6 mice distributed into control, exercise, ov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8485e7d3f24872824f3784d63354f3a7
https://doi.org/10.1249/mss.0000000000000927
https://doi.org/10.1249/mss.0000000000000927
Autor:
Dennis Wolf, Cemil Korcan Ayata, Timoteo Marchini, Nathaly Anto Michel, Natalie Hoppe, Lisa Schulte, Alexander Peikert, Sanja Cicko, Christoph Bode, Jochen Reinöhl, Constantin von zur Mühlen, Marco Idzko, Sonja Hergeth, Peter Stachon, Andreas Zirlik, Bianca Dufner, Melanie Grimm
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Objective— Nucleotides such as ATP, ADP, UTP, and UDP serve as proinflammatory danger signals via purinergic receptors on their release to the extracellular space by activated or dying cells. UDP binds to the purinergic receptor Y 6 (P2Y 6 ) and pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe5ed5c1c422281187beb0139ead19b
https://doi.org/10.1161/atvbaha.114.303585
https://doi.org/10.1161/atvbaha.114.303585
Autor:
Korcan Ayata, Tobias Müller, Rodolfo de Paula Vieira, Thorsten Dürk, Sebastian Reuter, Diego J. Walther, Melanie Grimm, Stephan Sorichter, Daniel Duerschmied, Sanja Cicko, Marco Idzko, Christian Taube, J. Christian Virchow
Publikováno v:
American Journal of Respiratory and Critical Care Medicine, 187(5), 476-485
5-Hydroxytryptamine (5-HT) is involved in the pathogenesis of allergic airway inflammation (AAI). It is unclear, however, how 5-HT contributes to AAI and whether this depends on tryptophan hydroxylase (TPH) 1, the critical enzyme for peripheral 5-HT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52c71e758155f57b336049bc19b76e7
https://doi.org/10.1164/rccm.201208-1440oc
https://doi.org/10.1164/rccm.201208-1440oc
Autor:
Tobias Müller, Christopher Boehlke, Thorsten Dürk, Rodolfo de Paula Vieira, Sanja Cicko, Cemil Korcan Ayata, Simon C. Robson, K Baudiß, Julie Pelletier, Marco Idzko, Jean Sévigny, Melanie Grimm, Stephan Sorichter, Andreas Zech
Publikováno v:
Allergy. 68:472-480
Background Extracellular Adenosine-5′-Triphosphate (ATP) is known to accumulate in the lung, following allergen challenge, and contributes via activation of purinergic receptors on dendritic cells (DC), to the development of allergic airway inflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8497d815d35e159c0a03e3e26e625a47
https://doi.org/10.1111/all.12119
https://doi.org/10.1111/all.12119
Autor:
Lauren Mays, Rupert Handgretinger, Esther von Stebut, Michael S. D. Kormann, Nikolaus Rieber, Susanne Ammon-Treiber, Dominik Hartl, Mohammed Alkhaled, Melanie Grimm, Markus Mezger, Bernd Nürnberg, Jennifer Rottenberger, Eva Müller-Hermelink, Matthias Schwab, Benedikt Mothes, Sandra Beer-Hammer, Marco Idzko
Publikováno v:
Journal of Clinical Investigation. 123:1216-1228
Chemically modified mRNA is capable of inducing therapeutic levels of protein expression while circumventing the threat of genomic integration often associated with viral vectors. We utilized this novel therapeutic tool to express the regulatory T ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473a2b26c82af49abcd20cc7339fa339
https://doi.org/10.1172/jci65351
https://doi.org/10.1172/jci65351
Autor:
Eva Jüttner, Ulrike V. Gerlach, Andreas Beilhack, Alf Zerweck, Konrad Wilhelm, Neeraja Kambham, Tobias Müller, Francesco Di Virgilio, Jürgen Finke, Paul Fisch, Robert Zeiser, Christine D. Krempl, Marco Idzko, Christoph Dürr, Davide Ferrari, Patrizia Pellegatti, Melanie Grimm, Stephan Sorichter, Jayanthi Ganesan, Frank Gärtner
Publikováno v:
Nature Medicine. 16:1434-1438
Danger signals released upon cell damage can cause excessive immune-mediated tissue destruction such as that found in acute graft-versus-host disease (GVHD), allograft rejection and systemic inflammatory response syndrome. Given that ATP is found in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d58aab59e48c839446f0ecb032b936
https://doi.org/10.1038/nm.2242
https://doi.org/10.1038/nm.2242