Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Melanie Ginese"'
Host Genetic Background Influences BCG-Induced Antibodies Cross-Reactive to SARS-CoV-2 Spike Protein
Autor:
Aubrey G. Specht, Melanie Ginese, Sherry L. Kurtz, Karen L. Elkins, Harrison Specht, Gillian Beamer
Publikováno v:
Vaccines, Vol 12, Iss 3, p 242 (2024)
Mycobacterium bovis Bacillus Calmette-Guérin (BCG) protects against childhood tuberculosis; and unlike most vaccines, BCG broadly impacts immunity to other pathogens and even some cancers. Early in the COVID-19 pandemic, epidemiological studies iden
Externí odkaz:
https://doaj.org/article/05f13eedece24cbe8c4ea3a53b6945d8
Autor:
Abhineet Sheoran, Alison Carvalho, Ruby Pina Mimbela, Adam South, Samuel Major, Melanie Ginese, Donald Girouard, Saul Tzipori
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 7, p e0010690 (2022)
BackgroundThe piglet is the only model to investigate the immunogenic relationship between Cryptosporidium hominis and C. parvum, the species responsible for diarrhea in humans. Despite being indistinguishable antigenically, and high genetic homology
Externí odkaz:
https://doaj.org/article/58cd2af033e047a1945b2e4ba2d57956
Autor:
Thomas E. Tavolara, M.K.K. Niazi, Adam C. Gower, Melanie Ginese, Gillian Beamer, Metin N. Gurcan
Publikováno v:
EBioMedicine, Vol 67, Iss , Pp 103388- (2021)
Background: Machine learning sustains successful application to many diagnostic and prognostic problems in computational histopathology. Yet, few efforts have been made to model gene expression from histopathology. This study proposes a methodology w
Externí odkaz:
https://doaj.org/article/df3c9ce645ef48a7a247bf13f6008e24
Autor:
Thomas E. Tavolara, M. Khalid Khan Niazi, Melanie Ginese, Cesar Piedra-Mora, Daniel M. Gatti, Gillian Beamer, Metin N. Gurcan
Publikováno v:
EBioMedicine, Vol 62, Iss , Pp 103094- (2020)
Background: Identifying which individuals will develop tuberculosis (TB) remains an unresolved problem due to few animal models and computational approaches that effectively address its heterogeneity. To meet these shortcomings, we show that Diversit
Externí odkaz:
https://doaj.org/article/a7309d5b120b437387d926e6e407ef85
Autor:
Christopher D. Huston, Damon M. Osbourn, David W. Griggs, Sangun Lee, Don Girouard, Gillian Beamer, Saul Tzipori, Melanie Ginese
Publikováno v:
J Infect Dis
Background Cryptosporidiosis, an enteric protozoon, causes substantial morbidity and mortality associated with diarrhea in children 75% of diarrhea reported in these children. Methods Gnotobiotic piglets were orally challenged with C hominis oocysts,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c50a808db40b5cf56b20015c5a39e3
https://doi.org/10.1093/infdis/jiz105
https://doi.org/10.1093/infdis/jiz105
Autor:
Gillian Beamer, Muhammad Khalid Khan Niazi, Metin N. Gurcan, Melanie Ginese, Thomas E. Tavolara, Adam C. Gower
Publikováno v:
EBioMedicine
EBioMedicine, Vol 67, Iss, Pp 103388-(2021)
EBioMedicine, Vol 67, Iss, Pp 103388-(2021)
Background Machine learning sustains successful application to many diagnostic and prognostic problems in computational histopathology. Yet, few efforts have been made to model gene expression from histopathology. This study proposes a methodology wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2234a38022f1c7a9a044c64091a86d
https://pubmed.ncbi.nlm.nih.gov/34000621
https://pubmed.ncbi.nlm.nih.gov/34000621
Autor:
Daniel M. Gatti, Melanie Ginese, Claudia Abeijon, Deniz Koyuncu, Thomas E. Tavolara, Bülent Yener, M. Khalid Khan Niazi, Gillian Beamer, Carolyn Mark, Metin N. Gurcan, Igor Kramnik, Adam C. Gower, Yanghui Liao
BackgroundBiomarker discovery for pulmonary tuberculosis (TB) may be accelerated by modeling human genotypic diversity and phenotypic responses toMycobacterium tuberculosis(Mtb). To meet these objectives, we use the Diversity Outbred (DO) mouse popul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8eaf7f05b5b0745f5ef715ac9c3a7476
https://doi.org/10.1101/2021.01.08.20249024
https://doi.org/10.1101/2021.01.08.20249024
Autor:
Carolyn Mark, Igor Kramnik, Bülent Yener, Daniel M. Gatti, Metin N. Gurcan, Melanie Ginese, Adam C. Gower, Muhammad Khalid Khan Niazi, Aubrey Specht, Gillian Beamer, Claudia Abeijon, Thomas E. Tavolara, Yanghui Liao, Deniz Koyuncu, Blanca I. Restrepo
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 8, p e1009773 (2021)
PLoS Pathogens, Vol 17, Iss 8, p e1009773 (2021)
More humans have died of tuberculosis (TB) than any other infectious disease and millions still die each year. Experts advocate for blood-based, serum protein biomarkers to help diagnose TB, which afflicts millions of people in high-burden countries.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436b25eb10615846dbdc2132d876822e
https://doi.org/10.1371/journal.ppat.1009773
https://doi.org/10.1371/journal.ppat.1009773
Autor:
Saul Tzipori, Hillary R Danz, Sangun Lee, Gillian Beamer, Susan Chapman-Bonofiglio, Melanie Ginese, Donald J Girouard
Publikováno v:
The Journal of infectious diseases. 221(2)
Nosocomial infections with Clostridium difficile are on the rise in the Unites States, attributed to emergence of antibiotic-resistant and hypervirulent strains associated with greater likelihood of recurrent infections. In addition to antibiotics, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4503ee5cab7f531d406b38c4afe7d09
https://pubmed.ncbi.nlm.nih.gov/31495879
https://pubmed.ncbi.nlm.nih.gov/31495879
Autor:
Gillian Beamer, Daniel M. Gatti, Melanie Ginese, Metin N. Gurcan, M. Khalid Khan Niazi, Thomas E. Tavolara, Cesar Piedra-Mora
Publikováno v:
EBioMedicine
EBioMedicine, Vol 62, Iss, Pp 103094-(2020)
EBioMedicine, Vol 62, Iss, Pp 103094-(2020)
Background Identifying which individuals will develop tuberculosis (TB) remains an unresolved problem due to few animal models and computational approaches that effectively address its heterogeneity. To meet these shortcomings, we show that Diversity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c4e6c257d68408294191ef74fd6c38a
https://doi.org/10.1016/j.ebiom.2020.103094
https://doi.org/10.1016/j.ebiom.2020.103094