Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Melanie Galla"'
Autor:
Larissa Nassauer, Hinrich Staecker, Peixin Huang, Bryan Renslo, Madeleine Goblet, Jennifer Harre, Athanasia Warnecke, Juliane W. Schott, Michael Morgan, Melanie Galla, Axel Schambach
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 1, Pp 102157- (2024)
Cisplatin is a highly effective chemotherapeutic agent, but it can cause sensorineural hearing loss (SNHL) in patients. Cisplatin-induced ototoxicity is closely related to the accumulation of reactive oxygen species (ROS) and subsequent death of hair
Externí odkaz:
https://doaj.org/article/fa09f49038244138abbce7ed6e21d4c8
Autor:
Anton Selich, Jenni Fleischauer, Tina Roepke, Luisa Weisskoeppel, Melanie Galla, Constantin von Kaisenberg, Ulrich A. Maus, Axel Schambach, Michael Rothe
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Background Mesenchymal stromal cells (MSCs) are excessively investigated in the context of inflammation-driven diseases, but the clinical results are often moderate. MSCs are naturally activated by inflammatory signals, which lead to the sec
Externí odkaz:
https://doaj.org/article/7c94c09531e44c77b8ccdeeb9ca36465
Autor:
Nadja Seltrecht, Matthias Hardtke-Wolenski, Konstantinos Iordanidis, Danny Jonigk, Melanie Galla, Axel Schambach, Laura Elisa Buitrago-Molina, Heiner Wedemeyer, Fatih Noyan, Elmar Jaeckel
Publikováno v:
Cells, Vol 13, Iss 14, p 1216 (2024)
Background: Solid organ transplantation is hindered by immune-mediated chronic graft dysfunction and the side effects of immunosuppressive therapy. Regulatory T cells (Tregs) are crucial for modulating immune responses post-transplantation; however,
Externí odkaz:
https://doaj.org/article/4429a14562044937a921119004b57d0a
Autor:
Berislav Bošnjak, Elisa Henze, Yvonne Lueder, Kim Thi Hoang Do, Alaleh Rezalotfi, Berislav Čuvalo, Christiane Ritter, Anja Schimrock, Stefanie Willenzon, Hristo Georgiev, Lea Fritz, Melanie Galla, Karen Wagner, Martin Messerle, Reinhold Förster
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112597- (2023)
Summary: Murine cytomegalovirus (MCMV) infection of macrophages relies on MCMV-encoded chemokine 2 (MCK2), while infection of fibroblasts occurs independently of MCK2. Recently, MCMV infection of both cell types was found to be dependent on cell-expr
Externí odkaz:
https://doaj.org/article/4f0929654e204d4eb067896845d94756
Autor:
Yvonne Baron, Johanna Sens, Lucas Lange, Larissa Nassauer, Denise Klatt, Dirk Hoffmann, Marc-Jens Kleppa, Philippe Vollmer Barbosa, Maximilian Keisker, Viviane Steinberg, Julia D. Suerth, Florian W.R. Vondran, Johann Meyer, Michael Morgan, Axel Schambach, Melanie Galla
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 810-823 (2022)
DNA-modifying technologies, such as the CRISPR-Cas9 system, are promising tools in the field of gene and cell therapies. However, high and prolonged expression of DNA-modifying enzymes may cause cytotoxic and genotoxic side effects and is therefore u
Externí odkaz:
https://doaj.org/article/7d3c9c912d7a421e93b440a7eebf070a
Autor:
Rieke Martens, Marc Permanyer, Kathrin Werth, Kai Yu, Asolina Braun, Olga Halle, Stephan Halle, Gwendolyn E. Patzer, Berislav Bošnjak, Friedemann Kiefer, Anika Janssen, Michaela Friedrichsen, Jenny Poetzsch, Karan Kohli, Yvonne Lueder, Rodrigo Gutierrez Jauregui, Nadine Eckert, Tim Worbs, Melanie Galla, Reinhold Förster
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Immune cells mostly enter lymph nodes (LN) from blood circulation, but whether afferent lymphatics contributes to LN entry is unclear. Here, the authors show, using a photo-convertible reporter, that T cells in afferent lymphatics frequently enter LN
Externí odkaz:
https://doaj.org/article/b8963b2416da4786a23a0db5ee2b12ab
Autor:
Loreen Sophie Rudek, Katharina Zimmermann, Melanie Galla, Johann Meyer, Johannes Kuehle, Andriana Stamopoulou, Daniel Brand, I. Erol Sandalcioglu, Belal Neyazi, Thomas Moritz, Claudia Rossig, Bianca Altvater, Christine S. Falk, Hinrich Abken, Michael Alexander Morgan, Axel Schambach
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Immune cell therapeutics are increasingly applied in oncology. Especially chimeric antigen receptor (CAR) T cells are successfully used to treat several B cell malignancies. Efforts to engineer CAR T cells for improved activity against solid tumors i
Externí odkaz:
https://doaj.org/article/2a54408c3f4a4724be8b0023202931c6
Autor:
Yvonne Knopp, Franziska K. Geis, Dirk Heckl, Stefan Horn, Thomas Neumann, Johannes Kuehle, Janine Meyer, Boris Fehse, Christopher Baum, Michael Morgan, Johann Meyer, Axel Schambach, Melanie Galla
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 13, Iss , Pp 256-274 (2018)
The recently discovered CRISPR/Cas9 system is widely used in basic research and is a useful tool for disease modeling and gene editing therapies. However, long-term expression of DNA-modifying enzymes can be associated with cytotoxicity and is partic
Externí odkaz:
https://doaj.org/article/2595b6871a8e4673b10f1cd8093290c6
Autor:
Franziska K. Geis, Melanie Galla, Dirk Hoffmann, Johannes Kuehle, Daniela Zychlinski, Tobias Maetzig, Juliane W. Schott, Adrian Schwarzer, Christine Goffinet, Stephen P. Goff, Axel Schambach
Publikováno v:
Retrovirology, Vol 14, Iss 1, Pp 1-15 (2017)
Abstract Background Retroviral vectors are derived from wild-type retroviruses, can be used to study retrovirus-host interactions and are effective tools in gene and cell therapy. However, numerous cell types are resistant or less permissive to retro
Externí odkaz:
https://doaj.org/article/90f7e4752ff0410b8c88e36b068c3079
Autor:
Swantje I. Hammerschmidt, Kathrin Werth, Michael Rothe, Melanie Galla, Marc Permanyer, Gwendolyn E. Patzer, Anja Bubke, David N. Frenk, Anton Selich, Lucas Lange, Axel Schambach, Berislav Bošnjak, Reinhold Förster
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
To present antigens to cognate T cells, dendritic cells (DCs) exploit the chemokine receptor CCR7 to travel from peripheral tissue via afferent lymphatic vessels to directly enter draining lymph nodes through the floor of the subcapsular sinus. Here,
Externí odkaz:
https://doaj.org/article/257304072d3544159c04aa87243fb8fc