Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Melanie F. Struve"'
Autor:
David C. Dorman, Kevin W. Gaido, Mark A. Sochaski, Kim Lehmann, Susan M. Ross, Janan B. Hensley, Gabrielle A. Willson, Melanie F. Struve
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 86:345-354
Most rodent developmental toxicity studies of dibutylphthalate (DBP) have relied on bolus gavage dosing. This study characterized the developmental toxicity of dietary DBP. Pregnant CD rats were given nominal doses of 0, 100, or 500 mg DBP/kg/day in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f256143211ff4f8d68001fd3f854d61e
https://doi.org/10.1002/bdrb.20199
https://doi.org/10.1002/bdrb.20199
Autor:
Teresa L. Leavens, Pheona M. Radcliffe, E. R. Wilfong, Gail D. Chapman, Dean J. Wagner, Melanie F. Struve, Ayodele O. Olabisi, Brian A. Wong, David C. Dorman
Publikováno v:
NeuroToxicology. 30:445-450
Olfactory transport of represents an important mechanism for direct delivery of certain metals to the central nervous system (CNS). The objective of this study was to determine whether inhaled tungsten (W) undergoes olfactory uptake and transport to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::160d02c74b94d2bcf642b174ec8f7549
https://doi.org/10.1016/j.neuro.2009.02.004
https://doi.org/10.1016/j.neuro.2009.02.004
Autor:
David C. Dorman, Pu Gao, Barbara A. Wetmore, Melanie F. Struve, Mark J. Nicolich, Daniel J. Letinski, Neil Allison, Sheela Sharma, Kay C. Roberts, Michael G. Bird
Publikováno v:
Chemico-Biological Interactions. 173:166-178
Benzene is an important industrial chemical. At certain levels, benzene has been found to produce aplastic anemia, pancytopenia, myeloblastic anemia and genotoxic effects in humans. Metabolism by cytochrome P450 monooxygenases and myeloperoxidase to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1a85a173d1e651a62c84f40302c333
https://doi.org/10.1016/j.cbi.2008.03.012
https://doi.org/10.1016/j.cbi.2008.03.012
Publikováno v:
Journal of Applied Toxicology. 27:631-636
In vitro, the organophosphate insecticide fenitrothion is a potent competitive androgen receptor antagonist, whereas in vivo it affects the development of the male rat reproductive system. The purpose of this pilot study was to determine whether pren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28cabbeea037d7ae59838dba8c30fe76
https://doi.org/10.1002/jat.1267
https://doi.org/10.1002/jat.1267
Publikováno v:
NeuroToxicology. 27:752-764
There is increased interest within the scientific community concerning the neurotoxicity of manganese owing in part to the use of methylcyclopentadienyl manganese tricarbonyl (MMT) as a gasoline fuel additive and an enhanced awareness that this essen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b3b6ca76bf063e7988b4025e88dfdf
https://doi.org/10.1016/j.neuro.2006.03.003
https://doi.org/10.1016/j.neuro.2006.03.003
Publikováno v:
Toxicological Sciences. 92:219-227
High-dose manganese exposure is associated with parkinsonism. Because manganese is paramagnetic, its relative distribution within the brain can be examined using magnetic resonance imaging (MRI). Herein, we present the first comprehensive study to us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d74e57500109e1f9770ac3724c8569f7
https://doi.org/10.1093/toxsci/kfj209
https://doi.org/10.1093/toxsci/kfj209
Publikováno v:
Toxicology and Applied Pharmacology. 198:29-39
The goal of this study was to characterize the toxicity of hydrogen sulfide (H2S), including nasal and pulmonary effects, in adult male and female Fischer-344 and Sprague-Dawley rats and B6C3F1 mice. Animals underwent whole-body exposure to 0, 10, 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a066b94715b7e8ea2011e15a5c63c657
https://doi.org/10.1016/j.taap.2004.03.010
https://doi.org/10.1016/j.taap.2004.03.010
Autor:
Kevin W. Gaido, Norman J. Barlow, David C. Dorman, Duncan G. Wallace, Paul M. D. Foster, Melanie F. Struve, Katie J. Turner
Publikováno v:
Toxicological Sciences. 68:174-183
Fenitrothion [0,0-dimethyl-O-(4-nitro-m-tolyl) phosphorothioate] is an organophosphate insecticide that has been shown to have antiandrogenic activity using in vitro and in vivo screening assays. Studies were performed to evaluate the ability of feni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f808b4a07cddcfae1a700d90dca8a5
https://doi.org/10.1093/toxsci/68.1.174
https://doi.org/10.1093/toxsci/68.1.174
Autor:
Kristen C. Mahle, Melanie F. Struve, R. Arden James, Frederic Moulin, Brian E. McManus, David C. Dorman
Publikováno v:
Toxicological Sciences. 65:18-25
Hydrogen sulfide (H2S) is an important brain, lung, and nose toxicant. Inhibition of cytochrome oxidase is the primary biochemical effect associated with lethal H2S exposure. The objective of this study was to evaluate the relationship between the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d44b6d3a672d52bbc368ff05568186d7
https://doi.org/10.1093/toxsci/65.1.18
https://doi.org/10.1093/toxsci/65.1.18
Autor:
Melanie F. Struve, David C. Dorman, R. Arden James, Brian E. McManus, Marianne W. Marshall, Brian A. Wong
Publikováno v:
Toxicological Sciences. 60:242-251
Concerns exist as to whether individuals with relative manganese deficiency or excess may be at increased risk for manganese toxicity following inhalation exposure. The objective of this study was to determine whether manganese body burden influences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4683c7a3627e8d65352a09417a09b918
https://doi.org/10.1093/toxsci/60.2.242
https://doi.org/10.1093/toxsci/60.2.242