Acute Ablation of Cortical Pericytes Leads to Rapid Neurovascular Uncoupling

Autor: Kassandra Kisler, Angeliki M. Nikolakopoulou, Melanie D. Sweeney, Divna Lazic, Zhen Zhao, Berislav V. Zlokovic

Publikováno v: Frontiers in Cellular Neuroscience, Vol 14 (2020)

Pericytes are perivascular mural cells that enwrap brain capillaries and maintain blood-brain barrier (BBB) integrity. Most studies suggest that pericytes regulate cerebral blood flow (CBF) and oxygen delivery to activated brain structures, known as

Externí odkaz: https://doaj.org/article/28de6ba6bd92495e905d8871bd05e4c6

Associations between Vascular Function and Tau PET Are Associated with Global Cognition and Amyloid

Autor: Lon S. Schneider, Teresa Monreal, Daniel S. Albrecht, Kay Jann, Arthur W. Toga, Elizabeth Joe, A. Lisette Isenberg, Berislav V. Zlokovic, Joy Stradford, Peter S. Conti, Abhay P. Sagare, Melanie D. Sweeney, Maricarmen Pachicano, Judy Pa, Helena C. Chui

Publikováno v: J Neurosci

Tau pathology and vascular dysfunction are important contributors to Alzheimer's disease (AD), but vascular–tau associations and their effects on cognition are poorly understood. We investigated these associations in male and female humans by condu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85065bf6ed3540db41eda9cf08c1efdb
https://doi.org/10.1523/jneurosci.1230-20.2020

APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline

Autor: Giuseppe Barisano, Anne M. Fagan, Michael G. Harrington, Tammie L.S. Benzinger, Meng Law, Melanie D. Sweeney, Maricarmen Pachicano, Julia Tcw, John C. Morris, Peter S. Conti, Lon S. Schneider, Axel Montagne, Arthur W. Toga, Lina M. D'Orazio, Elizabeth Joe, Amy R. Nelson, Richard J. Caselli, John M. Ringman, Helena C. Chui, Berislav V. Zlokovic, Daniel A. Nation, Yining Chen, Ararat Chakhoyan, Abhay P. Sagare, David P. Buennagel, Eric M. Reiman, Judy Pa

Publikováno v: Nature
Nature, vol 581, iss 7806

Vascular contributions to dementia and Alzheimer's disease are increasingly recognized1-6. Recent studies have suggested that breakdown of the blood-brain barrier (BBB) is an early biomarker of human cognitive dysfunction7, including the early clinic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a39ff74e068d8e2191a4c057182f8b6
http://europepmc.org/articles/PMC7250000

Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss

Autor: Mikko T Huuskonen, Xiaochun Xie, Pan Kong, Melanie D. Sweeney, Berislav V. Zlokovic, Kassandra Kisler, Erica J. Lawson, Zhonghua Dai, Nelly Chuqui Owens, Divna Lazic, Abhay P. Sagare, Zhen Zhao, Yaoming Wang, Axel Montagne, Angeliki M. Nikolakopoulou, Min Wang

Publikováno v: Nature Neuroscience

Pericytes are positioned between brain capillary endothelial cells, astrocytes and neurons. They degenerate in multiple neurological disorders. However, their role in the pathogenesis of these disorders remains debatable. Here we generate an inducibl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a9ca7926c1887bf9b5efe9650faeee0
https://doi.org/10.1038/s41593-019-0434-z

Perivascular spaces in the brain:anatomy, physiology and pathology

Autor: Joel Ramirez, Hedok Lee, Davide Boido, Joanna M. Wardlaw, Ravi L. Rungta, Humberto Mestre, Fergus N. Doubal, Kenneth Smith, Rosalind Brown, Bradley J. MacIntosh, Anne Joutel, Helene Benveniste, Lucia Ballerini, Allen Tannenbaum, Serge Charpak, Axel Montagne, Berislav V. Zlokovic, Sandra E. Black, Melanie D. Sweeney

Publikováno v: Wardlaw, J M, Benveniste, H, Nedergaard, M, Zlokovic, B V, Mestre, H, Lee, H, Doubal, F N, Brown, R, Ramirez, J, MacIntosh, B J, Tannenbaum, A, Ballerini, L, Rungta, R L, Boido, D, Sweeney, M, Montagne, A, Charpak, S, Joutel, A, Smith, K J & Black, S E 2020, ' Perivascular spaces in the brain : anatomy, physiology and pathology ', Nature Reviews. Neurology, vol. 16, pp. 137-153 . https://doi.org/10.1038/s41582-020-0312-z
Wardlaw, J M, Benveniste, H, Nedergaard, M, Zlokovic, B V, Mestre, H, Lee, H, Doubal, F N, Brown, R, Ramirez, J, Macintosh, B J, Tannenbaum, A, Ballerini, L, Rungta, R L, Boido, D, Sweeney, M, Montagne, A, Charpak, S, Joutel, A, Smith, K J & Black, S E 2020, ' Perivascular spaces in the brain : anatomy, physiology and pathology ', Nature Reviews Neurology, vol. 16, no. 3, pp. 137-153 . https://doi.org/10.1038/s41582-020-0312-z

Perivascular spaces include a variety of passageways around arterioles, capillaries and venules in the brain, along which a range of substances can move. Although perivascular spaces were first identified over 150 years ago, they have come to promine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63fde4a92578b32a8fc5bb081e21d71f
https://curis.ku.dk/ws/files/290446533/Wardlaw_edited_accepted_1575044479_2_JMW.pdf