Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Melanie D. Balhuizen"'
Autor:
Nico van Os, Ali Javed, Femke Broere, Albert van Dijk, Melanie D. Balhuizen, Martin van Eijk, Suzan H.M. Rooijakkers, Bart W. Bardoel, Dani A.C. Heesterbeek, Henk P. Haagsman, Edwin Veldhuizen
Publikováno v:
Journal of Global Antimicrobial Resistance, Vol 30, Iss , Pp 406-413 (2022)
ABSTRACT: Objectives: Our group recently developed a new group of antimicrobial peptides termed PepBiotics, of which peptides CR-163 and CR-172 showed optimized antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus without i
Externí odkaz:
https://doaj.org/article/4befd28c10f3431d952e270e4740cb56
Autor:
Roel M. van Harten, Johanna L.M. Tjeerdsma-van Bokhoven, Astrid de Greeff, Melanie D. Balhuizen, Albert van Dijk, Edwin J.A. Veldhuizen, Henk P. Haagsman, Maaike R. Scheenstra
Publikováno v:
Journal of Advanced Research, Vol 36, Iss , Pp 101-112 (2022)
Introduction: Due to the increase of antibiotic resistant bacterial strains, there is an urgent need for development of alternatives to antibiotics. Cathelicidins can be such an alternative to antibiotics having both a direct antimicrobial capacity a
Externí odkaz:
https://doaj.org/article/56f2c3a709914fcabbd62c5e4030ba46
Autor:
Ali Javed, Melanie D. Balhuizen, Arianne Pannekoek, Floris J. Bikker, Dani A. C. Heesterbeek, Henk P. Haagsman, Femke Broere, Markus Weingarth, Edwin J. A. Veldhuizen
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1485 (2023)
The binding of Host Defense Peptides (HDPs) to the endotoxin of Gram-negative bacteria has important unsolved aspects. For most HDPs, it is unclear if binding is part of the antibacterial mechanism or whether LPS actually provides a protective layer
Externí odkaz:
https://doaj.org/article/4987097ab3a24735b6ab4d4bbe807274
Autor:
Eline F. de Jonge, Melanie D. Balhuizen, Ria van Boxtel, Jianjun Wu, Henk P. Haagsman, Jan Tommassen
Publikováno v:
Current Research in Microbial Sciences, Vol 2, Iss , Pp 100009- (2021)
Pertussis, also known as whooping cough, is caused by the Gram-negative bacterium Bordetella pertussis, an obligate human pathogen. Despite high vaccination rates in high-income countries, resurgence of pertussis cases is an occurring problem that ur
Externí odkaz:
https://doaj.org/article/94b62ea94fb54ecf9b89971ab5bbd900
Autor:
Melanie D. Balhuizen, Chantal M. Versluis, Roel M. van Harten, Eline F. de Jonge, Jos F. Brouwers, Chris H.A. van de Lest, Edwin J.A. Veldhuizen, Jan Tommassen, Henk P. Haagsman
Publikováno v:
Current Research in Microbial Sciences, Vol 2, Iss , Pp 100010- (2021)
Host defense peptides (HDPs), such as cathelicidins, are small, cationic, amphipathic peptides and represent an important part of the innate immune system. Most cathelicidins, including the porcine PMAP-36, are membrane active and disrupt the bacteri
Externí odkaz:
https://doaj.org/article/50ce85dddf5846178b3ee968d0292b68
Autor:
Melanie D. Balhuizen, Albert van Dijk, Jeroen W. A. Jansen, Chris H. A. van de Lest, Edwin J. A. Veldhuizen, Henk P. Haagsman
Publikováno v:
mSphere, Vol 6, Iss 4 (2021)
Antibiotic resistance is a pressing problem and estimated to be a leading cause of mortality by 2050. Antimicrobial peptides, also known as host defense peptides (HDPs), and HDP-derived antimicrobials have potent antimicrobial activity and high poten
Externí odkaz:
https://doaj.org/article/d3cc60f1c485413a823c3e5c82f8825d
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Gram-negative bacteria release vesicular structures from their outer membrane, so called outer membrane vesicles (OMVs). OMVs have a variety of functions such as waste disposal, communication, and antigen or toxin delivery. These vesicles are the pro
Externí odkaz:
https://doaj.org/article/c25e8f183c79436a92f9133721c68924
Autor:
Lianci Peng, Wenjuan Du, Melanie D. Balhuizen, Henk P. Haagsman, Cornelis A. M. de Haan, Edwin J. A. Veldhuizen
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Cathelicidins (CATHs) are host defense peptides (HDPs) that play an important role in the innate immune response against infections. Although multiple functions of cathelicidins have been described, including direct antimicrobial activity and several
Externí odkaz:
https://doaj.org/article/3644800c49bc4797b380a68063949500
Autor:
Michael Landreh, Ákos Végvári, Peter Bergman, Birgitta Agerberth, Anders Lindén, Astrid Gräslund, Melanie D. Balhuizen, Cecilia Wallin, Margaretha E. Smith, Maarten Coorens, Edwin J.A. Veldhuizen, Salma Al-Adwani, Ingemar Qvarfordt
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports, 10(1). NLM (Medline)
Scientific Reports
Scientific Reports, 10(1). NLM (Medline)
Scientific Reports
Arginine residues of the antimicrobial peptide LL-37 can be citrullinated by peptidyl arginine deiminases, which reduce the positive charge of the peptide. Notably, citrullinated LL-37 has not yet been detected in human samples. In addition, function
Autor:
Eline F, de Jonge, Melanie D, Balhuizen, Ria, van Boxtel, Jianjun, Wu, Henk P, Haagsman, Jan, Tommassen
Publikováno v:
Current Research in Microbial Sciences
Highlights • Heat inactivation of Bordetella stimulates outer membrane vesicle (hOMVs) release. • hOMVs are released without extensive cell lysis. • Protein composition of hOMVs is similar to that of spontaneous OMVs (sOMVs). • Protein compos