Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Melanie D, Mark"'
Autor:
Ruxandra Barzan, Beyza Bozkurt, Mohammadreza M. Nejad, Sandra T. Süß, Tatjana Surdin, Hanna Böke, Katharina Spoida, Zohre Azimi, Michelle Grömmke, Dennis Eickelbeck, Melanie D. Mark, Lennard Rohr, Ida Siveke, Sen Cheng, Stefan Herlitze, Dirk Jancke
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Response gain is a crucial means by which modulatory systems control the impact of sensory input. In the visual cortex, the serotonergic 5-HT2A receptor is key in such modulation. However, due to its expression across different cell types an
Externí odkaz:
https://doaj.org/article/4677b8bf48824430a69725e8821ff54c
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract This study emphasizes the benefits of open-source software such as DeepLabCut (DLC) and R to automate, customize and enhance data analysis of motor behavior. We recorded 2 different spinocerebellar ataxia type 6 mouse models while performing
Externí odkaz:
https://doaj.org/article/60279aa31a3e436081ba63691f9b13d1
Autor:
Katrina E. Deane, Ruslan Klymentiev, Jennifer Heck, Melanie D. Mark, Frank W. Ohl, Martin Heine, Max F. K. Happel
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
IntroductionThe emergent coherent population activity from thousands of stochastic neurons in the brain is believed to constitute a key neuronal mechanism for salient processing of external stimuli and its link to internal states like attention and p
Externí odkaz:
https://doaj.org/article/11aba9cca4d2494fa89ba6d3e032043d
Autor:
Tatjana Surdin, Bianca Preissing, Lennard Rohr, Michelle Grömmke, Hanna Böke, Maike Barcik, Zohre Azimi, Dirk Jancke, Stefan Herlitze, Melanie D. Mark, Ida Siveke
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105828- (2023)
Summary: Neuronal plasticity underlying cerebellar learning behavior is strongly associated with type 1 metabotropic glutamate receptor (mGluR1) signaling. Activation of mGluR1 leads to activation of the Gq/11 pathway, which is involved in inducing s
Externí odkaz:
https://doaj.org/article/7b7d692bca43476ebd4c71542d3697e2
Autor:
Satya Srirama Karthik Divvela, Eric Bekoe Offei, Florian Suerland, David Revuelta García, Julia Kwiatkowski, Ajeesh Balakrishnan-Renuka, Pauline Bohne, Marion Böing, Gabriela Morosan-Puopolo, Melanie D. Mark, Beate Brand-Saberi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Atonal Homolog 8 (Atoh8) belongs to a large superfamily of transcriptional regulators called basic helix-loop-helix (bHLH) transcription factors. Atoh8 (murine homolog “Math6”) has been shown to be involved in organogenesis during murine embryoni
Externí odkaz:
https://doaj.org/article/f3a1c80580454ca6bf996428a4cf7b2a
Autor:
Raziye Karapinar, Jan Claudius Schwitalla, Dennis Eickelbeck, Johanna Pakusch, Brix Mücher, Michelle Grömmke, Tatjana Surdin, Thomas Knöpfel, Melanie D. Mark, Ida Siveke, Stefan Herlitze
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Microbial rhodopsins can be used to control action potentials, while animal opsins can be used to control intracellular signaling pathways. The authors identify Opn7b as constitutively active Gi/o coupled receptor that can be deactivated by light and
Externí odkaz:
https://doaj.org/article/cd6b728c8c2a41f6902c7cf1ab408a53
Autor:
Adam Fekete, Yukihiro Nakamura, Yi-Mei Yang, Stefan Herlitze, Melanie D. Mark, David A. DiGregorio, Lu-Yang Wang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The mechanisms underlying synaptic heterogeneity of neurotransmission at mature calyx synapses remain unclear. Here, authors identify two morphological modules that have distinct topology of calcium channel clusters and spatial coupling distance to s
Externí odkaz:
https://doaj.org/article/342e2fb457a34f4ab2812f5d3c07851d
Autor:
Max Rybarski, David Mrohs, Katharina Osenberg, Maren Hemmersbach, Katharina Pfeffel, Joy Steinkamp, David Schmidt, Karina Violou, Ruth Schäning, Katja Schmidtke, Verian Bader, Michael Andriske, Pauline Bohne, Melanie D. Mark, Konstanze F. Winklhofer, Hermann Lübbert, Xin‐Ran Zhu
Publikováno v:
European Journal of Neuroscience. 57:739-761
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Astrocytes are the most abundant cell type within the central nervous system (CNS) with various functions. Furthermore, astrocytes show a regional and developmental heterogeneity traceable with specific markers. In this study, the influence of the lo
Externí odkaz:
https://doaj.org/article/6538c6f73ef24974ab2d31a62d049015
Autor:
Zohre Azimi, Ruxandra Barzan, Katharina Spoida, Tatjana Surdin, Patric Wollenweber, Melanie D Mark, Stefan Herlitze, Dirk Jancke
Publikováno v:
eLife, Vol 9 (2020)
Controlling gain of cortical activity is essential to modulate weights between internal ongoing communication and external sensory drive. Here, we show that serotonergic input has separable suppressive effects on the gain of ongoing and evoked visual
Externí odkaz:
https://doaj.org/article/d39f0964e4534c70a3e4975928c8dd43