Výsledky vyhledávání - "Melanie D, Leech"

Akademický článek

A Context-Dependent Role for αv Integrins in Regulatory T Cell Accumulation at Sites of Inflammation

Autor: Iris Mair, Stephanie E. J. Zandee, Iqbal S. Toor, Louise Saul, Rhoanne C. McPherson, Melanie D. Leech, Danielle J. Smyth, Richard A. O’Connor, Neil C. Henderson, Stephen M. Anderton

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Several inflammatory diseases including multiple sclerosis and inflammatory bowel disease have been associated with dysfunctional and/or reduced numbers of Foxp3+ regulatory T cells (Treg). While numerous mechanisms of action have been discovered by

Externí odkaz: https://doaj.org/article/71a9e22f44f044f6b76a20174ef74fc8

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Akademický článek

Epigenetic modification of the PD-1 (Pdcd1) promoter in effector CD4+ T cells tolerized by peptide immunotherapy

Autor: Rhoanne C McPherson, Joanne E Konkel, Catriona T Prendergast, John P Thomson, Raffaele Ottaviano, Melanie D Leech, Oliver Kay, Stephanie E J Zandee, Claire H Sweenie, David C Wraith, Richard R Meehan, Amanda J Drake, Stephen M Anderton

Publikováno v: eLife, Vol 3 (2014)

Clinically effective antigen-based immunotherapy must silence antigen-experienced effector T cells (Teff) driving ongoing immune pathology. Using CD4+ autoimmune Teff cells, we demonstrate that peptide immunotherapy (PIT) is strictly dependent upon s

Externí odkaz: https://doaj.org/article/75862575f3834eacaa2391d9b4e2cb34

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Akademický článek

Recognition of a high affinity MHC class I-restricted epitope of myelin oligodendrocyte glycoprotein by CD8+ T cells derived from autoantigen-deficient mice.

Autor: Melanie D Leech, Antonio eCarrillo-Vico, Roland S. Liblau, Stephen M Anderton

Publikováno v: Frontiers in Immunology, Vol 2 (2011)

CD4+ T cells have a well-defined pathogenic role in experimental autoimmune encephalomyelitis, the rodent model of multiple sclerosis (MS), yet CD8+ T cells are commonly found in MS lesions. To determine whether immunological tolerance might impact d

Externí odkaz: https://doaj.org/article/784c48f1617b40ceaf5c3f5b871488e5

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PD-1 expression is upregulated on adapted T cells in experimental autoimmune encephalomyelitis but is not required to maintain a hyporesponsive state

Autor: Iris, Mair, Dario, Besusso, Louise, Saul, Sarju D, Patel, Rahul, Ravindran, Rhoanne C, McPherson, Melanie D, Leech, Richard A, O'Connor, Stephen M, Anderton, Richard J, Mellanby

Publikováno v: European Journal of Immunology

T cell adaptation is an important peripheral tolerogenic process which ensures that the T cell population can respond effectively to pathogens but remains tolerant to self‐antigens. We probed the mechanisms of T cell adaptation using an experimenta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d2e0f4188f8f304119d8d997b7577cd
https://pubmed.ncbi.nlm.nih.gov/30485411

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IL-10-producing, ST2-expressing Foxp3(+) T cells in multiple sclerosis brain lesions

Autor: Iris Mair, Richard A. O’Connor, Stephen M. Anderton, Stephanie E J Zandee, Melanie D. Leech, Anna Williams

Publikováno v: Zandee, S E J, O'Connor, R A, Mair, I, Leech, M D, Williams, A & Anderton, S M 2017, ' IL-10-producing, ST2-expressing Foxp3(+) T cells in multiple sclerosis brain lesions ', Immunology and Cell Biology . https://doi.org/10.1038/icb.2017.3

CD4(+)Foxp3(+) T regulatory (Treg) cells provide a key defence against inflammatory disease, but also have an ability to produce pro-inflammatory cytokines. The evidence for these two possibilities in multiple sclerosis (MS) is controversial. However

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c1f8ee4ac9ad029300b2a88c09c92ff
https://www.pure.ed.ac.uk/ws/files/36019156/Zandee_et_al_REVISED_submitted_to_ICB_19_12_2016.pdf

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Combination peptide immunotherapy based on T-cell epitope mapping reduces allergen-specific IgE and eosinophilia in allergic airway inflammation

Autor: Sarah E. M. Howie, Paul M. Fitch, Stephen M. Anderton, Jürgen Schwarze, Claire Wilson, Anne Ilchmann, Karen J. Mackenzie, Amanda J. McFarlane, Melanie D. Leech

Publikováno v: Immunology. 138:258-268

Peptide immunotherapy using soluble peptides containing allergen‐derived immunodominant T‐cell epitopes holds therapeutic promise for allergic asthma. Previous studies in BALB/c mice using the immunodominant peptide epitope of chicken ovalbumin (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e41d48f47ed99f32e84f93421eca01d1
https://doi.org/10.1111/imm.12032

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PD-1 signalling in CD4+T cells restrains their clonal expansion to an immunogenic stimulus, but is not critically required for peptide-induced tolerance

Autor: Stephen M. Anderton, Melanie D. Leech, Joanne E. Konkel, Hideo Yagita, Friederike Frommer, Ari Waisman

Publikováno v: Immunology. 130:92-102

Summary The ultimate outcome of T-cell recognition of peptide–major histocompatibility complex (MHC) complexes is determined by the molecular context in which antigen presentation is provided. The paradigm is that, after exposure to peptides presen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612515937a31e0a8a903b5279225b944
https://doi.org/10.1111/j.1365-2567.2009.03216.x

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Contribution of Myelin Autoantigen Citrullination to T Cell Autoaggression in the Central Nervous System

Autor: Melanie D. Leech, Stephen M. Anderton, Antonio Carrillo-Vico

Publikováno v: Carrillo-Vico, A, Leech, M D & Anderton, S M 2010, ' Contribution of Myelin Autoantigen Citrullination to T Cell Autoaggression in the Central Nervous System ', Journal of Immunology, vol. 184, no. 6, pp. 2839-2846 . https://doi.org/10.4049/jimmunol.0903639

Breakdown in immunological self tolerance, leading to autoimmune diseases such as multiple sclerosis, might arise from immune recognition of self proteins that have undergone heightened posttranslational modification under pathophysiological conditio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3b5b2d5e209a6d61586eee0e7d21ed
https://doi.org/10.4049/jimmunol.0903639

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Methods for Ex Vivo Analysis of Immune Cell Function from the Central Nervous System

Autor: Darryl G, Turner, Melanie D, Leech, Richard A, O'Connor, Stephen M, Anderton

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1304

Experimental autoimmune encephalomyelitis (EAE) is an animal model commonly used to investigate the inflammatory response in organ-specific autoimmunity and a model of the early immune responses of multiple sclerosis.This protocol outlines the method

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b32a211e6e77b23ec1e7278e730a4788
https://pubmed.ncbi.nlm.nih.gov/25863784

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Induction of Enhanced Immunity to Intestinal Nematodes Using IL-9-Producing Dendritic Cells

Autor: Richard K. Grencis, Melanie D. Leech

Publikováno v: The Journal of Immunology. 176:2505-2511

Dendritic cells can be considered natural adjuvants and are able to act as cellular vaccines to protect against disease. Adoptive transfer of Ag-pulsed bone marrow-derived dendritic cells (BMDCs) enhanced expulsion of the intestinal nematode, Trichin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7431889859fc856f000a6cd301d1e1
https://doi.org/10.4049/jimmunol.176.4.2505

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