Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Melanie C. McKell"'
Autor:
Heather M. Evans, Destiny F. Schultz, Adam J. Boiman, Melanie C. McKell, Joseph E. Qualls, George S. Deepe
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT Hypoxia-inducible factor 1α (HIF-1α) regulates the immunometabolic phenotype of macrophages, including the orchestration of inflammatory and antimicrobial processes. Macrophages deficient in HIF-1α produce excessive quantities of the anti
Externí odkaz:
https://doaj.org/article/c030846ab2494680a642e283c692126d
Autor:
Melanie C. McKell, Rebecca R. Crowther, Stephanie M. Schmidt, Michelle C. Robillard, Rachel Cantrell, Maria A. Lehn, Edith M. Janssen, Joseph E. Qualls
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Macrophages are indispensable immune cells tasked at eliminating intracellular pathogens. Mycobacterium tuberculosis (Mtb), one of the most virulent intracellular bacterial pathogens known to man, infects and resides within macrophages. While macroph
Externí odkaz:
https://doaj.org/article/b6fbae7edb794379b09f502c787ed320
Autor:
Jarren R. Oates, Melanie C. McKell, Maria E. Moreno-Fernandez, Michelle S. M. A. Damen, George S. Deepe, Joseph E. Qualls, Senad Divanovic
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Obesity is a prevalent predisposing factor to non-alcoholic fatty liver disease (NAFLD), the most common chronic liver disease in the developed world. NAFLD spectrum of disease involves progression from steatosis (NAFL), to steatohepatitis (NASH), ci
Externí odkaz:
https://doaj.org/article/0e1438d604a745b8873224b13b844fb6
Publikováno v:
Molecular Therapy: Oncolytics, Vol 8, Iss , Pp 52-61 (2018)
High mobility group AT-hook 1 (HMGA1) protein is an oncogenic architectural transcription factor that plays an essential role in early development, but it is also implicated in many human cancers. Elevated levels of HMGA1 in cancer cells cause misreg
Externí odkaz:
https://doaj.org/article/458fef24a2bf4d28a3c8063482d2d38b
Autor:
Shannon M. Lange, Melanie C. McKell, Stephanie M. Schmidt, Austin P. Hossfeld, Vandana Chaturvedi, Jeremy M. Kinder, Jaclyn W. McAlees, Ian P. Lewkowich, Sing Sing Way, Joanne Turner, Joseph E. Qualls
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Activation, recruitment, and effector function of T lymphocytes are essential for control of mycobacterial infection. These processes are tightly regulated in T cells by the availability of l-arginine within the microenvironment. In turn, mycobacteri
Externí odkaz:
https://doaj.org/article/f779cae316be4969ae70c09a704d3f52
Autor:
Rebecca R. Crowther, Stephanie M. Schmidt, Shannon M. Lange, Melanie C. McKell, Michelle C. Robillard, Junfang Zhao, Wendy D. Haffey, Michael A. Wyder, Kenneth D. Greis, Kenneth D. R. Setchell, Joseph E. Qualls
Publikováno v:
The Journal of Immunology. 208:793-798
Metabolomics analyses suggest changes in amino acid abundance, particularly l-arginine (L-ARG), occur in patients with tuberculosis. Immune cells require L-ARG to fuel effector functions following infection. We have previously described an L-ARG synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32417746bdf2b1490c1024d4fb3b408c
https://doi.org/10.4049/jimmunol.2100652
https://doi.org/10.4049/jimmunol.2100652
Autor:
Joseph E. Qualls, Destiny F. Schultz, Heather M. Evans, George S. Deepe, Melanie C. McKell, Adam J. Boiman
Publikováno v:
mBio
mBio, Vol 12, Iss 6 (2021)
mBio, Vol 12, Iss 6 (2021)
Hypoxia-inducible factor 1α (HIF-1α) regulates the immunometabolic phenotype of macrophages, including the orchestration of inflammatory and antimicrobial processes. Macrophages deficient in HIF-1α produce excessive quantities of the anti-inflamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68818f11e10897f052624b453cb217e7
http://europepmc.org/articles/PMC8576535
http://europepmc.org/articles/PMC8576535
Autor:
Rebecca R. Crowther, Shannon M. Lange, Lisa C. Green, Junfang Zhao, S. Eleonore Köhler, Eusondia Arnett, Melanie C. McKell, Kenneth D.R. Setchell, Stephanie Schmidt, Joseph E. Qualls, Larry S. Schlesinger, Rebecca L. Bricker
Publikováno v:
Journal of Immunology, 202(6), 1747-1754. American Association of Immunologists
Immunonutrition as a therapeutic approach is rapidly gaining interest in the fight against infection. Targeting l-arginine metabolism is intriguing, considering this amino acid is the substrate for antimicrobial NO production by macrophages. The impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d16234f96a98c1a698142ac0cf8c8b
https://doi.org/10.4049/jimmunol.1801569
https://doi.org/10.4049/jimmunol.1801569
Autor:
Adam Lane, Duaa Mureb, Silvio Antoniak, Nigel Mackman, Rebecca R. Crowther, Melanie C. McKell, Jordan Whitt, Leah Rosenfeldt, Bal Krishan Sharma, Joseph E. Qualls, Matthew J. Flick, Theresa Alenghat, Joseph S. Palumbo, Alexander A. Boucher, Kris A. Steinbrecher, Jessica Shafer
Publikováno v:
Journal of thrombosis and haemostasis : JTH. 18(1)
BACKGROUND: Protease-activated receptor-1 (PAR-1) plays a major role in multiple disease processes, including colitis. Understanding the mechanisms coupling PAR-1 to disease pathogenesis is complicated by the fact that PAR-1 is broadly expressed acro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a0e6095fdf9b5b03d451288b922d40
https://pubmed.ncbi.nlm.nih.gov/31539206
https://pubmed.ncbi.nlm.nih.gov/31539206
Autor:
Rebecca R Crowther, Stephanie M Schmidt, Junfang Zhao, Melanie C McKell, Kenneth D Setchell, Joseph E Qualls
Publikováno v:
The Journal of Immunology. 206:53.03-53.03
Tuberculosis (TB), caused by Mycobacterium tuberculosis, is responsible for over 1 million deaths each year. Mycobacteria-infected dendritic cells (DCs) migrate to the lymph node to initiate adaptive immune priming, which is vital to antimycobacteria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08b130ad3a999007002e7007cfaacd5a
https://doi.org/10.4049/jimmunol.206.supp.53.03
https://doi.org/10.4049/jimmunol.206.supp.53.03