Výsledky vyhledávání - "Melanie C Zigler"

Akademický článek

YI 1.4 Increases in Circulating Trimethylamine-N-Oxide Contribute to the Development of Age-Related Aortic Stiffness in Humans and Mice

Autor: Abigail G Casso, Rachel A Gioscia-Ryan, Zachary J Sapinsley, Nicholas S VanDongen, Amy E Bazzoni, Andrew P Neilson, Melanie C Zigler, Kevin P Davy, Douglas R Seals, Vienna E Brunt

Publikováno v: Artery Research, Vol 26, Iss Supplement 1 (2020)

Age-related increases in aortic stiffness, assessed by pulse wave velocity (PWV), predict cardiovascular (CV)-related mortality, but the upstream drivers are incompletely understood. Purpose: To determine if higher circulating levels of the gut micr

Externí odkaz: https://doaj.org/article/3a8b1dee1b01463e9bc2d518fbf70fdf

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Female C57BL/6N mice are a viable model of aortic aging in women

Autor: Abigail G. Longtine, Ravinandan Venkatasubramanian, Melanie C. Zigler, Alexandra J. Lindquist, Sophia A. Mahoney, Nathan T. Greenberg, Nicholas S. VanDongen, Katelyn R. Ludwig, Kerrie L. Moreau, Douglas R. Seals, Zachary S. Clayton

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 324:H893-H904

Our study demonstrates that with aging, female C57BL/6N mice exhibit higher in vivo aortic stiffness, reduced modulus of elasticity, aortic wall structural and extracellular matrix remodeling, and elevations in systemic inflammation. These changes ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06070df51d925cdbe344930d42918d6c
https://doi.org/10.1152/ajpheart.00120.2023

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Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans

Autor: Amy E Bazzoni, Andrew P. Neilson, Abigail G. Casso, Vienna E. Brunt, Melanie C. Zigler, Douglas R. Seals, David A. Hutton, James J Richey, Zachary J Sapinsley, Zachary S. Clayton, Kevin P. Davy, Brian P. Ziemba, Nicholas S. VanDongen, Rachel A. Gioscia-Ryan

Publikováno v: Hypertension. 78:499-511

Aging is associated with stiffening of the large elastic arteries and consequent increases in systolic blood pressure (SBP), which together increase cardiovascular disease risk; however, the upstream mechanisms are incompletely understood. Using comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9e8e35313458aae36f33b041f9179b0
https://doi.org/10.1161/hypertensionaha.120.16895

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Lifelong voluntary aerobic exercise prevents age‐ and Western diet‐ induced vascular dysfunction, mitochondrial oxidative stress and inflammation in mice

Autor: Rachel A. Gioscia-Ryan, Zachary S. Clayton, Nicholas S. VanDongen, Brian P. Ziemba, Matthew J. Rossman, David A. Hutton, Micah L. Battson, Melanie C. Zigler, James J Richey, Lauren M. Cuevas, Douglas R. Seals

Publikováno v: J Physiol

KEY POINTS The results of the present study establish the temporal pattern of age-related vascular dysfunction across the adult lifespan in sedentary mice consuming a non-Western diet, and the underlying mechanisms The results demonstrate that consum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15d5aac7d26ad927f417306cf3744ef
https://doi.org/10.1113/jp280607

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Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans

Autor: Vienna E. Brunt, Andrew P. Neilson, Kevin P. Davy, Douglas R. Seals, Zachary J Sapinsley, Rachel A. Gioscia-Ryan, Brian P. Ziemba, Nicholas S. VanDongen, Abigail G. Casso, Melanie C. Zigler, James J Richey

Publikováno v: Hypertension. 76:101-112

Age-related vascular endothelial dysfunction is a major antecedent to cardiovascular diseases. We investigated whether increased circulating levels of the gut microbiome-generated metabolite trimethylamine-N-oxide induces endothelial dysfunction with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50587399cfcb0fae280ed912175a44ac
https://doi.org/10.1161/hypertensionaha.120.14759

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Late-life voluntary wheel running reverses age-related aortic stiffness in mice: a translational model for studying mechanisms of exercise-mediated arterial de-stiffening

Autor: Bradley S. Fleenor, Rachel A. Gioscia-Ryan, Zachary S. Clayton, Trent D. Evans, Matthew J. Rossman, Lawrence C. Johnson, Melanie C. Zigler, Jason S. Eng, Douglas R. Seals

Publikováno v: GeroScience

Aortic stiffening, assessed as pulse-wave velocity (PWV), increases with age and is an important antecedent to, and independent predictor of, cardiovascular diseases (CVD) and other clinical disorders of aging. Aerobic exercise promotes lower levels

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38426d1d4ba918de5172dc931ddb1194
https://europepmc.org/articles/PMC8050175/

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Lifelong physical activity attenuates age- and Western-style diet-related declines in physical function and adverse changes in skeletal muscle mass and inflammation

Autor: Matthew J. Rossman, David A. Hutton, Douglas R. Seals, Zachary S. Clayton, Kara L. Lubieniecki, Jamie N. Justice, Rachel A. Gioscia-Ryan, Melanie C. Zigler

Publikováno v: Experimental Gerontology. 157:111632

It is unknown if consumption of a Western diet (WD; high-fat/sucrose), versus a non-WD (healthy diet), accelerates declines in physical function over the adult lifespan, and whether regular voluntary activity attenuates age- and WD-associated decline

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f793bd876caed3d077b1d37889865b4
https://doi.org/10.1016/j.exger.2021.111632

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