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pro vyhledávání: '"Melanie C Grigg"'
Autor:
Jason W. Schmidberger, K. Swaminathan Iyer, Nicole M. Smith, Charles S. Bond, Jessica A Hargreaves, Melanie C Grigg, Arnold Ou, Cameron W. Evans, Megan L. O'Mara, Katie A. Wilson
Publikováno v:
Nucleic Acids Research
Aberrant KRAS signaling is a driver of many cancers and yet remains an elusive target for drug therapy. The nuclease hypersensitive element of the KRAS promoter has been reported to form secondary DNA structures called G-quadruplexes (G4s) which may
Autor:
Mahmoud A. S. Abdelhamid, Nicole M. Smith, Melanie C Grigg, Zoë A. E. Waller, Michelle O Ehiabor, Kelly L. Irving, Elisé P. Wright
Publikováno v:
Nucleic Acids Research
i-Motifs are widely used in nanotechnology, play a part in gene regulation and have been detected in human nuclei. As these structures are composed of cytosine, they are potential sites for epigenetic modification. In addition to 5-methyl- and 5-hydr