Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Melanie Bouthillette"'
Autor:
Richard E. Middleton, Valentina V. Jeliazkova-Mecheva, Damaris Diaz, Candia M. Kenific, George N. Nikov, Sanjiv J. Shah, Adam J. Schell, Bethany Hughes, Nadja Smotrov, Alexander A. Szewczak, Melanie Bouthillette, Hugh Nuthall, Deborah Walker, W. Colby Brown, Mark S. Shearman, Hua Zhou, Benito Munoz, Christian Fischer, Dan F. Savage, Joey L. Methot, Jonathan C. Cruz, Susan L. Zultanski, Nathan Bays, Dawn M. Mampreian
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4083-4087
Synthesis, SAR, and evaluation of aryl triazoles as novel gamma secretase modulators (GSMs) are presented in this communication. Starting from the literature and in-house leads, we evaluated a range of five-membered heterocycles as replacements for o
Autor:
Sujal V. Deshmukh, Susan L. Zultanski, George N. Nikov, Christopher M. Moxham, Armetta D. Hill, Lily Y. Moy, Nadya Smotrov, Christian Fischer, Hua Zhou, Joey L. Methot, Maria S. Michener, Bethany Hughes, Damaris Diaz, Zhenhua Wu, Jacquelynn J. Cook, Sanjiv J. Shah, Benito Munoz, Jonathan C. Cruz, Flobert Tanga, Nathan Bays, Melanie Bouthillette, Bo-Sheng Pan, Valentina V. Jeliazkova-Mecheva, Ikuo Hayashi, Mark S. Shearman, Candia M. Kenific, Deborah Walker
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(17)
Synthesis and SAR studies of novel triazolobenzazepinones as gamma secretase modulators (GSMs) are presented in this communication. Starting from our azepinone leads, optimization studies toward improving central lowering of Aβ42 led to the discover