Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Melanie Blasius"'
Autor:
Laura Ryder, Frederic Schrøder Arendrup, José Francisco Martínez, Goda Snieckute, Chiara Pecorari, Riyaz Ahmad Shah, Anders H. Lund, Melanie Blasius, Simon Bekker-Jensen
Publikováno v:
Cell Death and Disease, Vol 14, Iss 7, Pp 1-10 (2023)
Abstract Impairment of protein translation can cause stalling and collision of ribosomes and is a signal for the activation of ribosomal surveillance and rescue pathways. Despite clear evidence that ribosome collision occurs stochastically at a cellu
Externí odkaz:
https://doaj.org/article/f8cffef743ee4b129b054cb825d27f9d
Autor:
Valdemar Brimnes Ingemann Johansen, Goda Snieckute, Anna Constance Vind, Melanie Blasius, Simon Bekker-Jensen
Publikováno v:
Cells, Vol 12, Iss 6, p 969 (2023)
The kinase ZAKα acts as the proximal sensor of translational impairment and ribotoxic stress, which results in the activation of the MAP kinases p38 and JNK. Despite recent insights into the functions and binding partners of individual protein domai
Externí odkaz:
https://doaj.org/article/82764bf3504443e39c62a174a4391ca2
Autor:
Maxim A.X. Tollenaere, Christopher Tiedje, Simon Rasmussen, Julie C. Nielsen, Anna C. Vind, Melanie Blasius, Tanveer S. Batth, Niels Mailand, Jesper V. Olsen, Matthias Gaestel, Simon Bekker-Jensen
Publikováno v:
Cell Reports, Vol 26, Iss 13, Pp 3511-3521.e4 (2019)
Summary: Inflammatory signaling is restricted through degradation and the translational repression of cytokine mRNAs. A key factor in this regulation is tristetraprolin (TTP), an RNA-binding protein (RBP) that recruits RNA-destabilizing factors and t
Externí odkaz:
https://doaj.org/article/5588f8057b1148499dbf19a354bfd526
Publikováno v:
Antioxidants & Redox Signaling.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d39046bc173c29ecf83aad0d0607722
https://doi.org/10.1089/ars.2022.0157
https://doi.org/10.1089/ars.2022.0157
Publikováno v:
Free Radical Biology and Medicine. 201:38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac6f20787b4777de17e6bfecc7e1419e
https://doi.org/10.1016/j.freeradbiomed.2023.03.157
https://doi.org/10.1016/j.freeradbiomed.2023.03.157
Autor:
Laura Ryder, Goda Snieckute, Anna Constance Vind, Zhenzhen Wu, Melanie Blasius, Simon Bekker-Jensen
Publikováno v:
Free Radical Biology and Medicine. 201:11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9b63c3a10758f36a8fb2981162a56e0
https://doi.org/10.1016/j.freeradbiomed.2023.03.066
https://doi.org/10.1016/j.freeradbiomed.2023.03.066
Autor:
Goda Snieckute, Aitana Victoria Genzor, Anna Constance Vind, Laura Ryder, Mark Stoneley, Sébastien Chamois, René Dreos, Cathrine Nordgaard, Frederike Sass, Melanie Blasius, Aida Rodríguez López, Sólveig Hlín Brynjólfsdóttir, Kasper Langebjerg Andersen, Anne E. Willis, Lisa B. Frankel, Steen Seier Poulsen, David Gatfield, Zachary Gerhart-Hines, Christoffer Clemmensen, Simon Bekker-Jensen
Publikováno v:
Cell Metabolism
Cell metabolism, vol. 34, no. 12, pp. 2036-2046.e8
Snieckute, G, Genzor, A V, Vind, A C, Ryder, L, Stoneley, M, Chamois, S, Dreos, R, Nordgaard, C, Sass, F, Blasius, M, López, A R, Brynjólfsdóttir, S H, Andersen, K L, Willis, A E, Frankel, L B, Poulsen, S S, Gatfield, D, Gerhart-Hines, Z, Clemmensen, C & Bekker-Jensen, S 2022, ' Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response ', Cell Metabolism, vol. 34, no. 12, pp. 2036-2046.e8 . https://doi.org/10.1016/j.cmet.2022.10.011
Cell metabolism, vol. 34, no. 12, pp. 2036-2046.e8
Snieckute, G, Genzor, A V, Vind, A C, Ryder, L, Stoneley, M, Chamois, S, Dreos, R, Nordgaard, C, Sass, F, Blasius, M, López, A R, Brynjólfsdóttir, S H, Andersen, K L, Willis, A E, Frankel, L B, Poulsen, S S, Gatfield, D, Gerhart-Hines, Z, Clemmensen, C & Bekker-Jensen, S 2022, ' Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response ', Cell Metabolism, vol. 34, no. 12, pp. 2036-2046.e8 . https://doi.org/10.1016/j.cmet.2022.10.011
Impairment of translation can lead to collisions of ribosomes, which constitute an activation platform for several ribosomal stress-surveillance pathways. Among these is the ribotoxic stress response (RSR), where ribosomal sensing by the MAP3K ZAKα
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3d0569649abd95832585e8b3d41f58
Autor:
Cathrine Nordgaard, Anna Constance Vind, Amy Stonadge, Rasmus Kjøbsted, Goda Snieckute, Pedro Antas, Melanie Blasius, Marie Sofie Reinert, Ana Martinez Del Val, Dorte Breinholdt Bekker‐Jensen, Peter Haahr, Yekaterina A Miroshnikova, Abdelghani Mazouzi, Sarah Falk, Emeline Perrier‐Groult, Christopher Tiedje, Xiang Li, Jens Rithamer Jakobsen, Nicolas Oldenburg Jørgensen, Jørgen FP Wojtaszewski, Frederic Mallein‐Gerin, Jesper Løvind Andersen, Cristian Pablo Pennisi, Christoffer Clemmensen, Moustapha Kassem, Abbas Jafari, Thijn Brummelkamp, Vivian SW Li, Sara A Wickström, Jesper Velgaard Olsen, Gonzalo Blanco, Simon Bekker‐Jensen
Publikováno v:
EMBO Journal
Nordgaard, C, Vind, A C, Stonadge, A, Kjøbsted, R, Snieckute, G, Antas, P, Blasius, M, Reinert, M S, Del Val, A M, Bekker-Jensen, D B, Haahr, P, Miroshnikova, Y A, Mazouzi, A, Falk, S, Perrier-Groult, E, Tiedje, C, Li, X, Jakobsen, J R, Jørgensen, N O, Wojtaszewski, J, Mallein-Gerin, F, Andersen, J L, Pennisi, C P, Clemmensen, C, Kassem, M, Jafari, A, Brummelkamp, T, Li, V S, Wickström, S A, Olsen, J V, Blanco, G & Bekker-Jensen, S 2022, ' ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle ', E M B O Journal, vol. 41, no. 17, e111650 . https://doi.org/10.15252/embj.2022111650
Nordgaard, C, Vind, A C, Stonadge, A, Kjøbsted, R, Snieckute, G, Antas, P, Blasius, M, Reinert, M S, Del Val, A M, Bekker-Jensen, D B, Haahr, P, Miroshnikova, Y A, Mazouzi, A, Falk, S, Perrier-Groult, E, Tiedje, C, Li, X, Jakobsen, J R, Jørgensen, N O, Wojtaszewski, J F, Mallein-Gerin, F, Andersen, J L, Pennisi, C P, Clemmensen, C, Kassem, M, Jafari, A, Brummelkamp, T, Li, V S, Wickström, S A, Olsen, J V, Blanco, G & Bekker-Jensen, S 2022, ' ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle ', The EMBO Journal, vol. 41, no. 17, e111650 . https://doi.org/10.15252/embj.2022111650
Nordgaard, C, Vind, A C, Stonadge, A, Kjøbsted, R, Snieckute, G, Antas, P, Blasius, M, Reinert, M S, Del Val, A M, Bekker-Jensen, D B, Haahr, P, Miroshnikova, Y A, Mazouzi, A, Falk, S, Perrier-Groult, E, Tiedje, C, Li, X, Jakobsen, J R, Jørgensen, N O, Wojtaszewski, J, Mallein-Gerin, F, Andersen, J L, Pennisi, C P, Clemmensen, C, Kassem, M, Jafari, A, Brummelkamp, T, Li, V S, Wickström, S A, Olsen, J V, Blanco, G & Bekker-Jensen, S 2022, ' ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle ', E M B O Journal, vol. 41, no. 17, e111650 . https://doi.org/10.15252/embj.2022111650
Nordgaard, C, Vind, A C, Stonadge, A, Kjøbsted, R, Snieckute, G, Antas, P, Blasius, M, Reinert, M S, Del Val, A M, Bekker-Jensen, D B, Haahr, P, Miroshnikova, Y A, Mazouzi, A, Falk, S, Perrier-Groult, E, Tiedje, C, Li, X, Jakobsen, J R, Jørgensen, N O, Wojtaszewski, J F, Mallein-Gerin, F, Andersen, J L, Pennisi, C P, Clemmensen, C, Kassem, M, Jafari, A, Brummelkamp, T, Li, V S, Wickström, S A, Olsen, J V, Blanco, G & Bekker-Jensen, S 2022, ' ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle ', The EMBO Journal, vol. 41, no. 17, e111650 . https://doi.org/10.15252/embj.2022111650
Mechanical inputs give rise to p38 and JNK activation, which mediate adaptive physiological responses in various tissues. In skeletal muscle, contraction-induced p38 and JNK signaling ensure adaptation to exercise, muscle repair, and hypertrophy. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156c500b42a0371cbd16c762afce2461
Autor:
Tanveer S. Batth, Christopher Tiedje, Niels Mailand, Julie C. Nielsen, Melanie Blasius, Simon Bekker-Jensen, Maxim A. X. Tollenaere, Simon Rasmussen, Jesper V. Olsen, Anna Vind, Matthias Gaestel
Publikováno v:
Cell Reports, Vol 26, Iss 13, Pp 3511-3521.e4 (2019)
Tollenaere, M A X, Tiedje, C, Rasmussen, S, Nielsen, J C, Vind, A C, Blasius, M, Batth, T S, Mailand, N, Olsen, J V, Gaestel, M & Bekker-Jensen, S 2019, ' GIGYF1/2-Driven Cooperation between ZNF598 and TTP in Posttranscriptional Regulation of Inflammatory Signaling ', Cell Reports, vol. 26, no. 13, pp. 3511-3521.e4 . https://doi.org/10.1016/j.celrep.2019.03.006
Tollenaere, M A X, Tiedje, C, Rasmussen, S, Nielsen, J C, Vind, A C, Blasius, M, Batth, T S, Mailand, N, Olsen, J V, Gaestel, M & Bekker-Jensen, S 2019, ' GIGYF1/2-Driven Cooperation between ZNF598 and TTP in Posttranscriptional Regulation of Inflammatory Signaling ', Cell Reports, vol. 26, no. 13, pp. 3511-3521.e4 . https://doi.org/10.1016/j.celrep.2019.03.006
Summary: Inflammatory signaling is restricted through degradation and the translational repression of cytokine mRNAs. A key factor in this regulation is tristetraprolin (TTP), an RNA-binding protein (RBP) that recruits RNA-destabilizing factors and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c988b5e06b99f8d07c495e207932ba4
http://www.sciencedirect.com/science/article/pii/S2211124719303134
http://www.sciencedirect.com/science/article/pii/S2211124719303134
Autor:
Simon Bekker-Jensen, Cathrine Nordgaard, Jesper V. Olsen, Ana Martinez Del Val, Dorte B. Bekker-Jensen, Maxim A. X. Tollenaere, Melanie Blasius
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 17
Nordgaard, C, Tollenaere, M A X, Del Val, A M, Bekker-Jensen, D B, Blasius, M, Olsen, J V & Bekker-Jensen, S 2021, ' Regulation of the golgi apparatus by p38 and JNK kinases during cellular stress responses ', International Journal of Molecular Sciences, vol. 22, no. 17, 9595 . https://doi.org/10.3390/ijms22179595
International Journal of Molecular Sciences, Vol 22, Iss 9595, p 9595 (2021)
Volume 22
Issue 17
Nordgaard, C, Tollenaere, M A X, Del Val, A M, Bekker-Jensen, D B, Blasius, M, Olsen, J V & Bekker-Jensen, S 2021, ' Regulation of the golgi apparatus by p38 and JNK kinases during cellular stress responses ', International Journal of Molecular Sciences, vol. 22, no. 17, 9595 . https://doi.org/10.3390/ijms22179595
International Journal of Molecular Sciences, Vol 22, Iss 9595, p 9595 (2021)
p38 and c-Jun N-terninal kinase (JNK) are activated in response to acute stress and inflammatory signals. Through modification of a plethora of substrates, these kinases profoundly re-shape cellular physiology for the optimal response to a harmful en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294994bbd08d6eedb6fa47dd661b7554