Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Melanie Balbach"'
Autor:
Melanie Balbach, Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Carla Ritagliati, Robert W. Myers, David J. Huggins, Clemens Steegborn, Ileana C. Miranda, Peter T. Meinke, Jochen Buck, Lonny R. Levin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Half of all pregnancies are unintended; thus, existing family planning options are inadequate. This proof-of-concept study validates an on-demand contraception strategy for men, showing high effectiveness in quickly and temporarily reducing male fert
Externí odkaz:
https://doaj.org/article/95c1debb563241228352ba4e29c74a64
Autor:
Ana Romarowski, Jasna Fejzo, Saman Nayyab, David Martin-Hidalgo, Maria G. Gervasi, Melanie Balbach, Sara Violante, Ana M. Salicioni, Justin Cross, Lonny R. Levin, Jochen Buck, Pablo E. Visconti
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Mammalian sperm must undergo capacitation to become fertilization-competent. While working on mice, we recently developed a new methodology for treating sperm in vitro, which results in higher rates of fertilization and embryo development after in vi
Externí odkaz:
https://doaj.org/article/6ffc929c917e44778766d6d8e9c7d9a5
Autor:
Melanie Balbach, Lubna Ghanem, Sara Violante, Aye Kyaw, Ana Romarowski, Justin R. Cross, Pablo E. Visconti, Lonny R. Levin, Jochen Buck
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Mammalian sperm require sufficient energy to support motility and capacitation for successful fertilization. Previous studies cataloging the changes to metabolism in sperm explored ejaculated human sperm or dormant mouse sperm surgically extracted fr
Externí odkaz:
https://doaj.org/article/bf9504cd7458481db05ef83880ae9942
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Targeted disruption of the soluble adenylyl cyclase (ADCY10; sAC) gene results in male-specific sterility without affecting spermatogenesis, mating behavior, or spermatozoa morphology and count; however, it dramatically impairs sperm motility and pre
Externí odkaz:
https://doaj.org/article/75032bd9c85b4addbd1c626742696f81
Autor:
Melanie Balbach, Hussein Hamzeh, Jan F. Jikeli, Christoph Brenker, Christian Schiffer, Jan N. Hansen, Pia Neugebauer, Christian Trötschel, Luca Jovine, Ling Han, Harvey M. Florman, U. Benjamin Kaupp, Timo Strünker, Dagmar Wachten
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Mammalian oocytes are enveloped by the zona pellucida (ZP), an extracellular matrix of glycoproteins. In sperm, stimulation with ZP proteins evokes a rapid Ca2+ influx via the sperm-specific, pH-sensitive Ca2+ channel CatSper. However, the physiologi
Externí odkaz:
https://doaj.org/article/87d6e04ca4ce4b2cb1e990ab3f22a423
Autor:
Shatanik Mukherjee, Vera Jansen, Jan F Jikeli, Hussein Hamzeh, Luis Alvarez, Marco Dombrowski, Melanie Balbach, Timo Strünker, Reinhard Seifert, U Benjamin Kaupp, Dagmar Wachten
Publikováno v:
eLife, Vol 5 (2016)
The cellular messenger cAMP regulates multiple cellular functions, including signaling in cilia and flagella. The cAMP dynamics in these subcellular compartments are ill-defined. We introduce a novel FRET-based cAMP biosensor with nanomolar sensitivi
Externí odkaz:
https://doaj.org/article/aaf3386b6d7b47d1b78fa1f71fd7c228
Autor:
Vera Jansen, Luis Alvarez, Melanie Balbach, Timo Strünker, Peter Hegemann, U Benjamin Kaupp, Dagmar Wachten
Publikováno v:
eLife, Vol 4 (2015)
Optogenetics is a powerful technique to control cellular activity by light. The light-gated Channelrhodopsin has been widely used to study and manipulate neuronal activity in vivo, whereas optogenetic control of second messengers in vivo has not been
Externí odkaz:
https://doaj.org/article/8a56fa87b1f74f0c94a2cdca436ed186
Autor:
Michael Miller, Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Melanie Balbach, Navpreet Kaur, Lonny R. Levin, Jochen Buck, Maria Kehr, Sandrine Coquille, Joop van den Heuvel, Clemens Steegborn, Makoto Fushimi, Efrat Finkin-Groner, Robert W. Myers, Stacia Kargman, Nigel J. Liverton, David J. Huggins, Peter T. Meinke
Publikováno v:
J Med Chem
Soluble adenylyl cyclase (sAC: ADCY10) is an enzyme involved in intracellular signaling. Inhibition of sAC has potential therapeutic utility in a number of areas. For example, sAC is integral to successful male fertility: sAC activation is required f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1b764b03322568b2d6bccba1a32f50
https://doi.org/10.1021/acs.jmedchem.2c01133
https://doi.org/10.1021/acs.jmedchem.2c01133
Autor:
Felipe Navarrete, Lonny R. Levin, Melanie Balbach, Jochen Buck, Ana Romarowski, Maria Gracia Gervasi, Pablo E. Visconti, Ana M. Salicioni, David Martin Hidalgo
Publikováno v:
Mol Reprod Dev
Mammalian sperm acquire fertilization capacity in the female reproductive tract in a process known as capacitation. During capacitation, sperm change their motility pattern (i.e., hyperactivation) and become competent to undergo the acrosome reaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8b4139e2c50b916b628d0885cf80fc
https://doi.org/10.1002/mrd.23421
https://doi.org/10.1002/mrd.23421
Autor:
Lonny R. Levin, Makoto Fushimi, Jochen Buck, David J. Huggins, Melanie Balbach, Clemens Steegborn, Peter T. Meinke
Publikováno v:
Biology of Reproduction
Efforts to develop new male or female nonhormonal, orally available contraceptives assume that to be effective and safe, targets must be (1) essential for fertility; (2) amenable to targeting by small-molecule inhibitors; and (3) restricted to the ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a8fa47c71526e351dd32340b3be292
http://europepmc.org/articles/PMC7401349
http://europepmc.org/articles/PMC7401349