Výsledky vyhledávání - "Melanie B. Laederich"

Ligand activation leads to regulated intramembrane proteolysis of fibroblast growth factor receptor 3

Autor: Melanie B. Laederich, William A. Horton, Catherine R. Degnin

Publikováno v: Molecular Biology of the Cell

FGFR3 is implicated in several human diseases. Following activation and endocytosis, FGFR3 undergoes sequential ectodomain and intramembrane cleavages to generate a soluble cytoplasmic fragment that can translocate to the nucleus.
Fibroblast gro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d1ba6e400e7c09c6b0166fcaf2717e6
https://doi.org/10.1091/mbc.e11-01-0080

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Fibroblast Growth Factor Receptor 3 (FGFR3) Is a Strong Heat Shock Protein 90 (Hsp90) Client

Autor: Melanie B. Laederich, G P Lunstrum, Catherine R. Degnin, William A. Horton, Paul Holden

Publikováno v: Journal of Biological Chemistry. 286:19597-19604

Fibroblast growth factor receptor 3 (FGFR3) is a key regulator of growth and differentiation, whose aberrant activation causes a number of genetic diseases including achondroplasia and cancer. Hsp90 is a specialized molecular chaperone involved in st

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https://doi.org/10.1074/jbc.m110.206151

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Achondroplasia: pathogenesis and implications for future treatment

Autor: William A. Horton, Melanie B. Laederich

Publikováno v: Current Opinion in Pediatrics. 22:516-523

Although the genetic defect underlying achondroplasia has been known for over a decade, no effective therapies to stimulate bone growth have emerged. Here we review the recent literature and summarize the molecular mechanisms underlying disease patho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2691e8588ebc8bd638ef1c988e58534a
https://doi.org/10.1097/mop.0b013e32833b7a69

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FGFs in endochondral skeletal development

Autor: William A. Horton, Catherine Degnin, Melanie B. Laederich

Publikováno v: Journal of Cellular Biochemistry. 110:1046-1057

The mammalian skeleton developments and grows through two complementary pathways: membranous ossification, which gives rise to the calvarial bones and distal clavicle, and endochondral ossification, which is responsible for the bones of the limbs, gi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71056110237f33f15a9a22d3dcaa1bb4
https://doi.org/10.1002/jcb.22629

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Sprouty 2 disturbs FGFR3 degradation in thanatophoric dysplasia type II: A severe form of human achondroplasia

Autor: Melanie B. Laederich, William A. Horton, Catherine R. Degnin, Gregory P. Lunstrum, Deborah Krakow, Changsheng Guo, Jeanie Bihlmaier, Paul Holden, Yoon Jae Cho

Publikováno v: Cellular Signalling. 20:1471-1477

Thanatophoric dysplasia is a member of the achondroplasia family of human skeletal dysplasias, which result from FGFR3 mutations that exaggerate this receptor's inhibitory influence on chondrocyte proliferation and differentiation in the skeletal gro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bce8686de9a438f9f1d941272ad7ad92
https://doi.org/10.1016/j.cellsig.2008.04.001

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LRIG1 negatively regulates the oncogenic EGF receptor mutant EGFRvIII

Autor: Kermit L. Carraway, Melanie B. Laederich, M. A. Stutz, Colleen A Sweeney, David L. Shattuck

Publikováno v: Oncogene. 27:5741-5752

Epidermal growth factor receptor (EGFR) mutation is frequently observed in human cancer and contributes to the growth, survival and therapeutic resistance of tumors. EGFRvIII is an oncogenic EGFR mutant resulting from the deletion of exons 2–7 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a443c32605d81f17ee3f3a03f53772c
https://doi.org/10.1038/onc.2008.185

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LRIG1 Is a Novel Negative Regulator of the Met Receptor and Opposes Met and Her2 Synergy

Autor: Kermit L. Carraway, Melanie B. Laederich, David L. Shattuck, Heidi Petersen, Melanie Funes, Jamie K. Miller, Colleen A Sweeney

Publikováno v: Molecular and Cellular Biology. 27:1934-1946

The Met receptor tyrosine kinase regulates a complex array of cellular behaviors collectively known as “invasive growth.” While essential for normal development and wound repair, this program is frequently co-opted by tumors to promote their own

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c250eaf84d5fc67db028f4ac9e915706
https://doi.org/10.1128/mcb.00757-06

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Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors

Autor: Nicolas Aznar, Alexandra C. Newton, Maya T. Kunkel, Pradipta Ghosh, Krishna Midde, Melanie B. Laederich, Gary S. Ma

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 112, iss 9
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2015, 112 (9), pp.E937-E946. ⟨10.1073/pnas.1420140112⟩

Environmental cues are transmitted to the interior of the cell via a complex network of signaling hubs. Receptor tyrosine kinases (RTKs) and trimeric G proteins are two such major signaling hubs in eukaryotes. Conventionally, canonical signal transdu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b5021ff9bad782e6aab2c951662eebb
https://pubmed.ncbi.nlm.nih.gov/25737539

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The Interaction of Piasy with Trim32, an E3-Ubiquitin Ligase Mutated in Limb-girdle Muscular Dystrophy Type 2H, Promotes Piasy Degradation and Regulates UVB-induced Keratinocyte Apoptosis through NFκB

Autor: Elizabeth J. Horn, Klaus Wrogemann, Amador Albor, Sally El-Hizawi, Melanie B. Laederich, Patrick Frosk, Molly Kulesz-Martin

Publikováno v: Journal of Biological Chemistry. 281:25850-25866

Protein inhibitors of activated STATs (PIAS) family members are ubiquitin-protein isopeptide ligase-small ubiquitin-like modifier ligases for diverse transcription factors. However, the regulation of PIAS protein activity in cells is poorly understoo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee847eae527c2220b857fc7beeb6147b
https://doi.org/10.1074/jbc.m601655200

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FGFR3 targeting strategies for achondroplasia

Autor: Melanie B. Laederich, William A. Horton

Publikováno v: Expert Reviews in Molecular Medicine. 14

Mutations that exaggerate signalling of the receptor tyrosine kinase fibroblast growth factor receptor 3 (FGFR3) give rise to achondroplasia, the most common form of dwarfism in humans. Here we review the clinical features, genetic aspects and molecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b5275cfa1015af4a6a37ae75b472fa
https://doi.org/10.1017/erm.2012.4

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