Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Melanie Abongwa"'
Autor:
Melanie Abongwa, Moses Samje, Godfred A. Ayimele, Smith B. Babiaka, Christina Bulman, Judy Sakanari, Nick J. Koszewski, Saurabh Verma, Jesse Goff, Fidelis Cho-Ngwa, Richard J. Martin, Alan P. Robertson
Publikováno v:
Parasites & Vectors, Vol 14, Iss 1, Pp 1-15 (2021)
Abstract Background Drugs currently used for controlling onchocerciasis and lymphatic filariasis (LF) are mainly microfilaricidal, with minimal or no effect on the adult worms. For efficient management of these diseases, it is necessary to search for
Externí odkaz:
https://doaj.org/article/ab912f354990437f95ca1f09a00a2334
Autor:
Shivani Choudhary, Djordje S. Marjianović, Colin R. Wong, Xiaoyu Zhang, Melanie Abongwa, Joel R. Coats, Saša M. Trailović, Richard J. Martin, Alan P. Robertson
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 9, Iss , Pp 44-53 (2019)
The ongoing and widespread emergence of resistance to the existing anti-nematodal pharmacopeia has made it imperative to develop new anthelminthic agents. Historically, plants have been important sources of therapeutic compounds and offer an alternat
Externí odkaz:
https://doaj.org/article/fc449c656a3544b195a2709908c920f0
Autor:
Melanie Abongwa, Djordje S. Marjanovic, James G. Tipton, Fudan Zheng, Richard J. Martin, Sasa M. Trailovic, Alan P. Robertson
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 1, Pp 36-42 (2018)
Zolvix® is a recently introduced anthelmintic drench containing monepantel as the active ingredient. Monepantel is a positive allosteric modulator of DEG-3/DES-2 type nicotinic acetylcholine receptors (nAChRs) in several nematode species. The drug h
Externí odkaz:
https://doaj.org/article/21caf0e812264b9d97581be5282b449c
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 6, Iss 1, Pp 60-73 (2016)
Soil-transmitted helminth infections in humans and livestock cause significant debility, reduced productivity and economic losses globally. There are a limited number of effective anthelmintic drugs available for treating helminths infections, and th
Externí odkaz:
https://doaj.org/article/ee236dfe09744167a5dbea41cf4df10c
Autor:
Shivani Choudhary, Melanie Abongwa, Sudhanva S. Kashyap, Saurabh Verma, Gunnar R. Mair, Daniel Kulke, Richard J. Martin, Alan P. Robertson
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Glutamate-gated chloride channels (GluCls) are unique to invertebrates and are targeted by macrocyclic lactones. In this study, we cloned an AVR-14B GluCl subunit from adult Brugia malayi , a causative agent of lymphatic filariasis in humans. To eluc
Autor:
Fidelis Cho-Ngwa, Alan P. Robertson, Nick J. Koszewski, Saurabh Verma, Richard J. Martin, Smith B. Babiaka, Christina A. Bulman, Jesse P. Goff, Moses Samje, Judy A. Sakanari, Godfred A. Ayimele, Melanie Abongwa
Publikováno v:
Parasites & Vectors, Vol 14, Iss 1, Pp 1-15 (2021)
Parasites & Vectors
Parasites & Vectors
Background Drugs currently used for controlling onchocerciasis and lymphatic filariasis (LF) are mainly microfilaricidal, with minimal or no effect on the adult worms. For efficient management of these diseases, it is necessary to search for new drug
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146854 (2016)
Nematode parasites may be controlled with drugs, but their regular application has given rise to concerns about the development of resistance. Drug combinations may be more effective than single drugs and delay the onset of resistance. A combination
Externí odkaz:
https://doaj.org/article/1f3cc213bfd84f43b3fb95f93e244db7
Autor:
Sasa M. Trailovic, Shivani Choudhary, Xiaoyu Zhang, Djordje S. Marjianović, Joel R. Coats, Alan P. Robertson, Richard J. Martin, Colin R. Wong, Melanie Abongwa
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 9, Iss, Pp 44-53 (2019)
International Journal for Parasitology-Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology-Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance
The ongoing and widespread emergence of resistance to the existing anti-nematodal pharmacopeia has made it imperative to develop new anthelminthic agents. Historically, plants have been important sources of therapeutic compounds and offer an alternat
Autor:
Samuel K Buxton, Claude L Charvet, Cedric Neveu, Jacques Cabaret, Jacques Cortet, Nicolas Peineau, Melanie Abongwa, Elise Courtot, Alan P Robertson, Richard J Martin
Publikováno v:
PLoS Pathogens, Vol 10, Iss 1, p e1003870 (2014)
Nicotinic acetylcholine receptors (nAChRs) of parasitic nematodes are required for body movement and are targets of important "classical" anthelmintics like levamisole and pyrantel, as well as "novel" anthelmintics like tribendimidine and derquantel.
Externí odkaz:
https://doaj.org/article/be0879b4a8b04c91a8eaccf07faabcc7
Publikováno v:
Acta Veterinaria, Vol 67, Iss 2, Pp 137-152 (2017)
Anthelmintics are some of the most widely used drugs in veterinary medicine. Here we review the mechanism of action of these compounds on nematode parasites. Included are the older classes of compounds; the benzimidazoles, cholinergic agonists and ma