Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Melanie A. Woodin"'
Autor:
Melissa Serranilla, Melanie A. Woodin
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Externí odkaz:
https://doaj.org/article/fce19a2ce95441fda73335eed444f303
Autor:
Melissa Serranilla, Melanie A. Woodin
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2022)
Intracellular chloride (Cl–) levels in mature neurons must be tightly regulated for the maintenance of fast synaptic inhibition. In the mature central nervous system (CNS), synaptic inhibition is primarily mediated by gamma-amino butyric acid (GABA
Externí odkaz:
https://doaj.org/article/a612d9e773a9446ab7a526814e62711e
Autor:
Christopher K. Salmon, Horia Pribiag, Claire Gizowski, W. Todd Farmer, Scott Cameron, Emma V. Jones, Vivek Mahadevan, Charles W. Bourque, David Stellwagen, Melanie A. Woodin, Keith K. Murai
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mature brain but has the paradoxical property of depolarizing neurons during early development. Depolarization provided by GABAA transmission during this early phase regulates
Externí odkaz:
https://doaj.org/article/d8b168c9aebd402997561d562df8c290
Autor:
Afif J. Aqrabawi, Caleb J. Browne, Zahra Dargaei, Danielle Garand, C. Sahara Khademullah, Melanie A. Woodin, Jun Chul Kim
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
The anterior olfactory nucleus pars medialis (mAON) provides cortical feedback to the olfactory bulb, but the behavioural relevance of these projections is unknown. Here, using opto- and chemogenetic approaches, the authors find the mAON bidirectiona
Externí odkaz:
https://doaj.org/article/25674281bedc4f6ea294e348f220b127
Autor:
Vivek Mahadevan, Jessica C. Pressey, Brooke A. Acton, Pavel Uvarov, Michelle Y. Huang, Jonah Chevrier, Andrew Puchalski, Caiwei M. Li, Evgueni A. Ivakine, Matti S. Airaksinen, Eric Delpire, Roderick R. McInnes, Melanie A. Woodin
Publikováno v:
Cell Reports, Vol 7, Iss 6, Pp 1762-1770 (2014)
KCC2 is the neuron-specific K+-Cl− cotransporter required for maintaining low intracellular Cl−, which is essential for fast inhibitory synaptic transmission in the mature CNS. Despite the requirement of KCC2 for inhibitory synaptic transmission,
Externí odkaz:
https://doaj.org/article/b8ef59d947984589b8a2fa36ba42ca80
Publikováno v:
Physiological Reviews. 103:1095-1135
Synaptic inhibition plays a crucial role in regulating neuronal excitability, which is the foundation of nervous system function. This inhibition is largely mediated by the neurotransmitters GABA and glycine that activate Cl−-permeable ion channels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ae9ebddd1c895471365d4f39a59d8d
https://doi.org/10.1152/physrev.00025.2021
https://doi.org/10.1152/physrev.00025.2021
Autor:
Xinyi Liang, Danielle Garand, Iason Keramidis, Julia Keith, Jun Chul Kim, Melanie A. Woodin, C. Sahara Khademullah, Afif J. Aqrabawi, Jessica C. Pressey, Simon Bedard, Kara M Place, Alicja Gasecka, Zahra Dargaei, Lorne Zinman, Janice Robertson, Jy Wei Yang, Daniel Côté, Yves De Koninck
Publikováno v:
Brain. 143:800-810
Amyotrophic lateral sclerosis is a fatal disease resulting from motor neuron degeneration in the cortex and spinal cord. Cortical hyperexcitability is a hallmark feature of amyotrophic lateral sclerosis and is accompanied by decreased intracortical i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c89b6eb8ef404180923f406dca70d7
https://doi.org/10.1093/brain/awaa034
https://doi.org/10.1093/brain/awaa034
Publikováno v:
Trends in Pharmacological Sciences. 41:897-899
Finely tuned excitation–inhibition balance is essential for proper brain function, and loss of balance resulting from reduced synaptic inhibition is associated with neurological disorders. Savardi and colleagues have discovered a novel inhibitor of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a1f48a9bc3f576afe821d237adee196
https://doi.org/10.1016/j.tips.2020.10.002
https://doi.org/10.1016/j.tips.2020.10.002
Autor:
Melanie A. Woodin, Danielle Garand, Wataru Inoue, Jun Chul Kim, Jee Yoon Bang, Julia Sunstrum, Gustavo M. Parfitt
Preys use their memory - where they sensed a predatory threat and whether a safe shelter is nearby - to dynamically control their survival instinct to avoid harm and reach safety. However, it remains unknown which brain regions are involved, and how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd68af68fa512b8951635ab52d21b869
https://doi.org/10.1101/2021.08.06.455454
https://doi.org/10.1101/2021.08.06.455454
Autor:
Vivek Mahadevan, Christopher K. Salmon, Horia Pribiag, Emma V. Jones, W. Todd Farmer, Claire Gizowski, David Stellwagen, Melanie A. Woodin, Scott Cameron, Keith K. Murai, Charles W. Bourque
Publikováno v:
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Frontiers in Cellular Neuroscience, Vol 14 (2020)
γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mature brain but has the paradoxical property of depolarizing neurons during early development. Depolarization provided by GABAA transmission during this early phase regulates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce1ca9ef64a1437a94a85d690a6fa32
https://doi.org/10.3389/fncel.2020.00036
https://doi.org/10.3389/fncel.2020.00036