Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Melanie A. O'Bara"'
Autor:
Darpan Saraswat, Hani J. Shayya, Jessie J. Polanco, Ajai Tripathi, R. Ross Welliver, Suyog U. Pol, Richard A. Seidman, Jacqueline E. Broome, Melanie A. O’Bara, Toin H. van Kuppervelt, Joanna J. Phillips, Ranjan Dutta, Fraser J. Sim
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Demyelination results in impairments in oligodendrocyte progenitor cell recruitment. Here the authors identify sulfatase 1/2 as a potential modulator of myelination by modulating the microenvironment around oligodendrocyte progenitor cells.
Externí odkaz:
https://doaj.org/article/8405f74419104281af9993328f364b19
Autor:
Suyog U. Pol, Jessie J. Polanco, Richard A. Seidman, Melanie A. O'Bara, Hani J. Shayya, Karen C. Dietz, Fraser J. Sim
Publikováno v:
Stem Cell Reports, Vol 9, Iss 2, Pp 710-723 (2017)
Summary: Impaired human oligodendrocyte progenitor cell (hOPC) differentiation likely contributes to failed remyelination in multiple sclerosis. The characterization of molecular pathways that regulate hOPC differentiation will provide means to induc
Externí odkaz:
https://doaj.org/article/9b894d1cfb8d4db6bcd2ef3678c96df5
Autor:
Jing Wang, Darpan Saraswat, Anjali K. Sinha, Jessie Polanco, Karen Dietz, Melanie A. O’Bara, Suyog U. Pol, Hani J. Shayya, Fraser J. Sim
Publikováno v:
Cell Reports, Vol 25, Iss 12, Pp 3435-3450.e6 (2018)
Summary: Human oligodendrocyte progenitor cells (hOPCs) persist into adulthood as an abundant precursor population capable of division and differentiation. The transcriptional mechanisms that regulate hOPC homeostasis remain poorly defined. Herein, w
Externí odkaz:
https://doaj.org/article/d1aa823735b24a81918352846063fe6d
Autor:
Panagiotis Douvaras, Jing Wang, Matthew Zimmer, Stephanie Hanchuk, Melanie A. O’Bara, Saud Sadiq, Fraser J. Sim, James Goldman, Valentina Fossati
Publikováno v:
Stem Cell Reports, Vol 3, Iss 2, Pp 250-259 (2014)
Multiple sclerosis (MS) is a chronic demyelinating disease of unknown etiology that affects the CNS. While current therapies are primarily directed against the immune system, the new challenge is to address progressive MS with remyelinating and neuro
Externí odkaz:
https://doaj.org/article/8225ab544f01445d8212fcf0ed7a5f37
Autor:
Jacqueline E. Broome, Ajai Tripathi, Fraser J. Sim, Darpan Saraswat, Suyog Pol, Ranjan Dutta, R. Ross Welliver, Melanie A. O'Bara, Hani J. Shayya, Jessie J. Polanco, Richard A. Seidman, Joanna J. Phillips, Toin H. van Kuppervelt
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Chronic demyelination in the human CNS is characterized by an inhibitory microenvironment that impairs recruitment and differentiation of oligodendrocyte progenitor cells (OPCs) leading to failed remyelination and axonal atrophy. By network-based tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd869a845f4787f2e1d1c13a69c255d
https://doi.org/10.1038/s41467-021-22263-4
https://doi.org/10.1038/s41467-021-22263-4
Autor:
Darpan Saraswat, Hani J. Shayya, Jessie J. Polanco, Ajai Tripathi, R. Ross Welliver, Suyog U. Pol, Richard A. Seidman, Jacqueline E. Broome, Melanie A. O’Bara, Toin H. van Kuppervelt, Joanna J. Phillips, Ranjan Dutta, Fraser J. Sim
Chronic demyelination in the human CNS is characterized by an inhibitory microenvironment that impairs recruitment and differentiation of oligodendrocyte progenitor cells (OPCs) leading to failed remyelination and axonal atrophy. By network-based tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce361fd858496b65b53a4a6dfad2c9de
Autor:
Karen C. Dietz, Jessie J. Polanco, Richard A. Seidman, Suyog Pol, Fraser J. Sim, Melanie A. O'Bara, Hani J. Shayya
Publikováno v:
Stem Cell Reports, Vol 9, Iss 2, Pp 710-723 (2017)
Stem Cell Reports
Stem Cell Reports
Summary Impaired human oligodendrocyte progenitor cell (hOPC) differentiation likely contributes to failed remyelination in multiple sclerosis. The characterization of molecular pathways that regulate hOPC differentiation will provide means to induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e03abbb9349bd294ea1928a90199edc0
http://www.sciencedirect.com/science/article/pii/S221367111730317X
http://www.sciencedirect.com/science/article/pii/S221367111730317X
Autor:
Pablo M. Paez, Jessie J. Polanco, M. Laura Feltri, Zainab M. Khaku, Melanie A. O'Bara, Fraser J. Sim, R. Ross Welliver, Richard A. Seidman, Akiko Nishiyama, Diara A. Santiago González, Jürgen Wess, Anjali K. Sinha
Muscarinic receptor antagonists act as potent inducers of oligodendrocyte differentiation and accelerate remyelination. However, the use of muscarinic antagonists in the clinic is limited by poor understanding of the operant receptor subtype, and que
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a23dd1d25badc74e83f7e90a3713ae8
https://europepmc.org/articles/PMC6070663/
https://europepmc.org/articles/PMC6070663/
Autor:
Stephanie Hanchuk, Valentina Fossati, Jing Wang, Panagiotis Douvaras, Melanie A. O'Bara, James E. Goldman, Saud Sadiq, Fraser J. Sim, Matthew Zimmer
Publikováno v:
Stem Cell Reports, Vol 3, Iss 2, Pp 250-259 (2014)
Stem Cell Reports
Stem Cell Reports
Summary Multiple sclerosis (MS) is a chronic demyelinating disease of unknown etiology that affects the CNS. While current therapies are primarily directed against the immune system, the new challenge is to address progressive MS with remyelinating a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5657f2508d990dc95919f1785287da0
http://www.sciencedirect.com/science/article/pii/S2213671114001982
http://www.sciencedirect.com/science/article/pii/S2213671114001982
Autor:
Fraser J. Sim, Darpan Saraswat, Melanie A. O'Bara, Hani J. Shayya, Jing Wang, Jessie J. Polanco, Suyog Pol, Anjali K. Sinha, Karen C. Dietz
Publikováno v:
Cell Reports, Vol 25, Iss 12, Pp 3435-3450.e6 (2018)
Summary: Human oligodendrocyte progenitor cells (hOPCs) persist into adulthood as an abundant precursor population capable of division and differentiation. The transcriptional mechanisms that regulate hOPC homeostasis remain poorly defined. Herein, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c61561250d9f49483130b630120ebf4
https://doi.org/10.1016/j.celrep.2018.11.068
https://doi.org/10.1016/j.celrep.2018.11.068