Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Melanie A. Krook"'
Autor:
Hui-Zi Chen, MD, PhD, Russell Bonneville, BS, Anoosha Paruchuri, PhD, Julie W. Reeser, PhD, Michele R. Wing, PhD, Eric Samorodnitsky, PhD, Melanie A. Krook, PhD, Amy M. Smith, BS, Thuy Dao, BS, Jharna Miya, MS, Walter Wang, BS, Lianbo Yu, PhD, Aharon G. Freud, MD, PhD, Patricia Allenby, MD, Sharon Cole, MD, Gregory Otterson, MD, Peter Shields, MD, David P. Carbone, MD, PhD, Sameek Roychowdhury, MD, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 2, Iss 4, Pp 100164- (2021)
Introduction: Relapsed SCLC is characterized by therapeutic resistance and high mortality rate. Despite decades of research, mechanisms responsible for therapeutic resistance have remained elusive owing to limited tissues available for molecular stud
Externí odkaz:
https://doaj.org/article/d41ee449b2bc4d2ab3b5a1f76d7484c9
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 18, Iss 8, Pp 480-488 (2016)
Metastatic Ewing sarcoma has a very poor prognosis and therefore new investigations into the biologic drivers of metastatic progression are key to finding new therapeutic approaches. The tumor microenvironment is highly dynamic, leading to exposure o
Externí odkaz:
https://doaj.org/article/20c87476c2da4bd088c8384bfba92ac3
Autor:
Sameek Roychowdhury, Aharon G. Freud, John Hays, Kristen K. Ciombor, Dorrelyn M. Martin, Thuy Dao, Amy M. Smith, Eric Samorodnitsky, Jharna Miya, Michele R. Wing, Julie W. Reeser, Hui-Zi Chen, Kelly M. Bailey, Mikayla Dantuono, Hannah Barker, Max Wilberding, Alexandria Lenyo, Melanie A. Krook
Primer sequences used for PCR and Sanger sequencing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b42608d465fb41549fd11c1548623d69
https://doi.org/10.1158/1535-7163.22519083
https://doi.org/10.1158/1535-7163.22519083
Autor:
Sameek Roychowdhury, Aharon G. Freud, John Hays, Kristen K. Ciombor, Dorrelyn M. Martin, Thuy Dao, Amy M. Smith, Eric Samorodnitsky, Jharna Miya, Michele R. Wing, Julie W. Reeser, Hui-Zi Chen, Kelly M. Bailey, Mikayla Dantuono, Hannah Barker, Max Wilberding, Alexandria Lenyo, Melanie A. Krook
The fibroblast growth factor receptor (FGFR) signaling pathway is aberrantly activated in approximately 15% to 20% of patients with intrahepatic cholangiocarcinoma. Currently, several FGFR kinase inhibitors are being assessed in clinical trials for p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5f6e892ef6a15aec83851e3e501d11
https://doi.org/10.1158/1535-7163.c.6542283.v1
https://doi.org/10.1158/1535-7163.c.6542283.v1
Autor:
Sameek Roychowdhury, Aharon G. Freud, John Hays, Kristen K. Ciombor, Dorrelyn M. Martin, Thuy Dao, Amy M. Smith, Eric Samorodnitsky, Jharna Miya, Michele R. Wing, Julie W. Reeser, Hui-Zi Chen, Kelly M. Bailey, Mikayla Dantuono, Hannah Barker, Max Wilberding, Alexandria Lenyo, Melanie A. Krook
Sequence for FGFR2-KIAA1598 fusion.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee6583ef2a4168c8f00b172f486ec2b
https://doi.org/10.1158/1535-7163.22519089.v1
https://doi.org/10.1158/1535-7163.22519089.v1
Autor:
Richard R. Neubig, Elizabeth R. Lawlor, Monique Verhaegen, Scott D. Larsen, Melanie A. Krook, Merlin Airik, Cheryl E. Rockwell, Jessica L. Bell, Susan M. Wade, Yajing Ji, Sean A. Misek, Erika M. Lisabeth, Kathryn M. Appleton, Andrew J. Haak
To show that MRTF-A localization was dependent on F-actin dynamics, we stimulated SK-Mel-19 cells with 20% FBS to induce stress fiber formation which induced MRTF-A nuclear localization. We also treated SK-Mel-147 cells with latrunculin B which inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1117c9e2a1495f7253941a73c0d5452d
https://doi.org/10.1158/1535-7163.22508319
https://doi.org/10.1158/1535-7163.22508319
Autor:
Sameek Roychowdhury, Aharon G. Freud, John Hays, Kristen K. Ciombor, Dorrelyn M. Martin, Thuy Dao, Amy M. Smith, Eric Samorodnitsky, Jharna Miya, Michele R. Wing, Julie W. Reeser, Hui-Zi Chen, Kelly M. Bailey, Mikayla Dantuono, Hannah Barker, Max Wilberding, Alexandria Lenyo, Melanie A. Krook
Sensitivity of the FGFR2 secondary mutations to FGFR inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2323b989b2e47681149c462f7de2ee90
https://doi.org/10.1158/1535-7163.22519086.v1
https://doi.org/10.1158/1535-7163.22519086.v1
Autor:
Richard R. Neubig, Elizabeth R. Lawlor, Monique Verhaegen, Scott D. Larsen, Melanie A. Krook, Merlin Airik, Cheryl E. Rockwell, Jessica L. Bell, Susan M. Wade, Yajing Ji, Sean A. Misek, Erika M. Lisabeth, Kathryn M. Appleton, Andrew J. Haak
The Cancer Genome Atlas (TCGA) cutaneous melanoma dataset was stratified into quartiles based upon expression of indicated genes. Kaplan-Meier plots were generated from the highest (grey) and lowest (black) expressing quartiles. Survival curves were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412fad174ba69ff2635cf96a88d4e660
https://doi.org/10.1158/1535-7163.22508322.v1
https://doi.org/10.1158/1535-7163.22508322.v1
Autor:
Ian M. Silverman, Meijuan Li, Karthikeyan Murugesan, Melanie A. Krook, Milind M. Javle, Robin K. Kelley, Mitesh J. Borad, Sameek Roychowdhury, Wei Meng, Bahar Yilmazel, Coren Milbury, Shantanu Shewale, Luis Feliz, Timothy C. Burn, Lee A. Albacker
Publikováno v:
The Journal of Molecular Diagnostics. 24:351-364
Cholangiocarcinoma (CCA) is a heterogeneous biliary tract cancer with a poor prognosis. Approximately 30% to 50% of patients harbor actionable alterations, including FGFR2 rearrangements. Pemigatinib, a potent, selective fibroblast growth factor rece
Autor:
Hannah Barker, Hui-Zi Chen, Gabrielle Ernst, Melanie A. Krook, Sameek Roychowdhury, Gary Li, Julie W. Reeser, Max Wilberding
Publikováno v:
British Journal of Cancer
Fibroblast growth factor receptors (FGFRs) are aberrantly activated through single-nucleotide variants, gene fusions and copy number amplifications in 5–10% of all human cancers, although this frequency increases to 10–30% in urothelial carcinoma