Whisker Deprivation Drives Two Phases of Inhibitory Synapse Weakening in Layer 4 of Rat Somatosensory Cortex.

Autor: Melanie A Gainey, Renna Wolfe, Olivia Pourzia, Daniel E Feldman

Publikováno v: PLoS ONE, Vol 11, Iss 2, p e0148227 (2016)

Inhibitory synapse development in sensory neocortex is experience-dependent, with sustained sensory deprivation yielding fewer and weaker inhibitory synapses. Whether this represents arrest of synapse maturation, or a more complex set of processes, i

Externí odkaz: https://doaj.org/article/217f55e2a43340e8b10ecb41855ce4f6

Multiple shared mechanisms for homeostatic plasticity in rodent somatosensory and visual cortex

Autor: Daniel E. Feldman, Melanie A. Gainey

Publikováno v: Philosophical transactions of the Royal Society of London. Series B, Biological sciences, vol 372, iss 1715

We compare the circuit and cellular mechanisms for homeostatic plasticity that have been discovered in rodent somatosensory (S1) and visual (V1) cortex. Both areas use similar mechanisms to restore mean firing rate after sensory deprivation. Two time

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c008adfae87d630af509bda320e0180
https://pubmed.ncbi.nlm.nih.gov/28093551

Activity-dependent synaptic GRIP1 accumulation drives synaptic scaling up in response to action potential blockade

Autor: Vedakumar Tatavarty, Heather Lin, Melanie A. Gainey, Marc Nahmani, Gina G. Turrigiano

Synaptic scaling is a form of homeostatic plasticity that stabilizes neuronal firing in response to changes in synapse number and strength. Scaling up in response to action-potential blockade is accomplished through increased synaptic accumulation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e12b2fbcb8028f58241b0f4c75ea78ba
https://europepmc.org/articles/PMC4500210/

Rapid homeostasis by disinhibition during whisker map plasticity

Autor: Lu Li, Joseph E. Goldbeck, Melanie A. Gainey, Daniel E. Feldman

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 111, iss 4
Li, L; Gainey, MA; Goldbeck, JE; & Feldman, DE. (2014). Rapid homeostasis by disinhibition during whisker map plasticity. Proceedings of the National Academy of Sciences of the United States of America, 111(4), 1616-1621. doi: 10.1073/pnas.1312455111. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/7h4666hm

How homeostatic processes contribute to map plasticity and stability in sensory cortex is not well-understood. Classically, sensory deprivation first drives rapid Hebbian weakening of spiking responses to deprived inputs, which is followed days later

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c78e73d5502a1fed99a322f165085a13
https://pubmed.ncbi.nlm.nih.gov/24474788