Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Melanie A Samuel"'
Autor:
Courtney A Burger, Jonathan Alevy, Anna K Casasent, Danye Jiang, Nicholas E Albrecht, Justine H Liang, Arlene A Hirano, Nicholas C Brecha, Melanie A Samuel
Publikováno v:
eLife, Vol 9 (2020)
Structural changes in pre and postsynaptic neurons that accompany synapse formation often temporally and spatially overlap. Thus, it has been difficult to resolve which processes drive patterned connectivity. To overcome this, we use the laminated ou
Externí odkaz:
https://doaj.org/article/28945f0d1256418a9198f66526f7224a
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46663 (2012)
As synapses form and mature the synaptic partners produce organizing molecules that regulate each other's differentiation and ensure precise apposition of pre- and post-synaptic specializations. At the skeletal neuromuscular junction (NMJ), these mol
Externí odkaz:
https://doaj.org/article/070f244967b64111b734c88317d48cef
Autor:
Poornima Parameswaran, Ella Sklan, Courtney Wilkins, Trever Burgon, Melanie A Samuel, Rui Lu, K Mark Ansel, Vigo Heissmeyer, Shirit Einav, William Jackson, Tammy Doukas, Suman Paranjape, Charlotta Polacek, Flavia Barreto dos Santos, Roxana Jalili, Farbod Babrzadeh, Baback Gharizadeh, Dirk Grimm, Mark Kay, Satoshi Koike, Peter Sarnow, Mostafa Ronaghi, Shou-Wei Ding, Eva Harris, Marie Chow, Michael S Diamond, Karla Kirkegaard, Jeffrey S Glenn, Andrew Z Fire
Publikováno v:
PLoS Pathogens, Vol 6, Iss 2, p e1000764 (2010)
We have used multiplexed high-throughput sequencing to characterize changes in small RNA populations that occur during viral infection in animal cells. Small RNA-based mechanisms such as RNA interference (RNAi) have been shown in plant and invertebra
Externí odkaz:
https://doaj.org/article/62a41c28d1794310899a7778de7d193c
Publikováno v:
PLoS Pathogens, Vol 3, Iss 7, p e106 (2007)
Interferon regulatory factor (IRF)-3 is a master transcription factor that activates host antiviral defense programs. Although cell culture studies suggest that IRF-3 promotes antiviral control by inducing interferon (IFN)-beta, near normal levels of
Externí odkaz:
https://doaj.org/article/87be695c931d4abc9e09d2d706e4472b
Autor:
Justine H. Liang, Jonathan Alevy, Viktor Akhanov, Ryan Seo, Cory A. Massey, Danye Jiang, Joy Zhou, Roy V. Sillitoe, Jeffrey L. Noebels, Melanie A. Samuel
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 9 (2022)
Externí odkaz:
https://doaj.org/article/bb86a84fc0014f568f07aa76a81811cb
Publikováno v:
Neural Development, Vol 14, Iss 1, Pp 1-13 (2019)
Abstract Microglia are increasingly shown to be key players in neuron development and synapse connectivity. However, the underlying mechanisms by which microglia regulate neuron function remain poorly understood in part because such analysis is chall
Externí odkaz:
https://doaj.org/article/adf400d9b16f4f13a6a7f678ccb1ee8f
Publikováno v:
Annual Review of Vision Science. 9
Because the central nervous system is largely nonrenewing, neurons and their synapses must be maintained over the lifetime of an individual to ensure circuit function. Age is a dominant risk factor for neural diseases, and declines in nervous system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7574edecec816a79976bf8a27b484732
https://doi.org/10.1146/annurev-vision-112122-020950
https://doi.org/10.1146/annurev-vision-112122-020950
Autor:
Brian A. Upton, Kevin X. Zhang, Melanie A. Samuel, Gregory W. Schwartz, Shane P. D'Souza, David Swygart, Sophia Rose Wienbar, Richard Lang, Anna K. Casasent, Robert D. Mackin
Publikováno v:
Journal of Comparative Neurology. 530:1247-1262
Obtaining a parts list of the sensory components of the retina is vital to understanding the effects of light in behavior, health, and disease. Rods, cones, and intrinsically photosensitive retinal ganglion cells (ipRGCs) are the best described photo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de47482e7003d658393dd830aedc745
https://doi.org/10.1002/cne.25272
https://doi.org/10.1002/cne.25272
Publikováno v:
Dev Biol
Synapses in the outer retina are the first information relay points in vision. Here, photoreceptors form synapses onto two types of interneurons, bipolar cells and horizontal cells. Because outer retina synapses are particularly large and highly orde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c10203c20b58af20e7be682de005d11
https://doi.org/10.1016/j.ydbio.2021.04.001
https://doi.org/10.1016/j.ydbio.2021.04.001
Autor:
Yan Cao, Diego Fajardo, Debbie Guerrero-Given, Melanie A. Samuel, Toshihisa Ohtsuka, Shannon E. Boye, Naomi Kamasawa, Kirill A. Martemyanov
Publikováno v:
Current biology : CB. 32(22)
The formation of neural circuits occurs in a programmed fashion, but proper activity in the circuit is essential for refining the organization necessary for driving complex behavioral tasks. In the retina, sensory deprivation during the critical peri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f615613bf572e20ec51beb971c84295f
https://pubmed.ncbi.nlm.nih.gov/36179691
https://pubmed.ncbi.nlm.nih.gov/36179691