Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Melanie A MacMullan"'
A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up- or downscaling
Autor:
Chi-Hong Wu, Vedakumar Tatavarty, Pierre M Jean Beltran, Andrea A Guerrero, Hasmik Keshishian, Karsten Krug, Melanie A MacMullan, Li Li, Steven A Carr, Jeffrey R Cottrell, Gina G Turrigiano
Publikováno v:
eLife, Vol 11 (2022)
Homeostatic synaptic plasticity requires widespread remodeling of synaptic signaling and scaffolding networks, but the role of post-translational modifications in this process has not been systematically studied. Using deep-scale quantitative analysi
Externí odkaz:
https://doaj.org/article/62dee5cecd974444b9a59db1da6ab44d
Autor:
Hasmik Keshishian, E Robert McDonald III, Filip Mundt, Randy Melanson, Karsten Krug, Dale A Porter, Luke Wallace, Dominique Forestier, Bokang Rabasha, Sara E Marlow, Judit Jane‐Valbuena, Ellen Todres, Harrison Specht, Margaret Lea Robinson, Pierre M Jean Beltran, Ozgun Babur, Meagan E Olive, Javad Golji, Eric Kuhn, Michael Burgess, Melanie A MacMullan, Tomas Rejtar, Karen Wang, DR Mani, Shankha Satpathy, Michael A Gillette, William R Sellers, Steven A Carr
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 9, Pp n/a-n/a (2021)
Abstract Reliable methods to quantify dynamic signaling changes across diverse pathways are needed to better understand the effects of disease and drug treatment in cells and tissues but are presently lacking. Here, we present SigPath, a targeted mas
Externí odkaz:
https://doaj.org/article/8c21ac714ff142d89c9c58dde8847a35
Autor:
Lao-Tzu Allan-Blitz, Omid Akbari, Noah Kojima, Edwyn Saavedra, Prithivi Chellamuthu, Nicholas Denny, Melanie A. MacMullan, Victoria Hess, Maria Shacreaw, Matthew Brobeck, Frederick Turner, Vladimir I. Slepnev, Albina Ibrayeva, Jeffrey D. Klausner
Publikováno v:
Clinical and Experimental Medicine.
Purpose Long COVID is estimated to occur in 5–10% of individuals after acute SARS-CoV-2 infection. However, the pathophysiology driving the disease process is poorly understood. Methods We evaluated urine and plasma inflammatory and immune cytokine
Autor:
Frederick E. Turner, Robert Brown, Prithivi Chellamuthu, Edwyn Saavedra, Nicholas Denny, Marilisa Santacruz, Aaron N. Angel, Melanie A. MacMullan, Maria Shacreaw, Lauren Lopez, Victoria Hess, Noah Kojima, Jeffery D. Klausner, Matthew Brobeck, Vladimir I. Slepnev, Albina Ibrayeva
Saliva specimens offer practical advantages over serum specimens for studying SARS-CoV-2 immunity following natural infections or vaccination. Salivary anti-spike (S)-protein immunoglobulin G (IgG) antibody titers are quantifiable by ELISA with high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91d588ce32af78116466a0f26873351e
https://doi.org/10.22541/au.167784336.67563988/v1
https://doi.org/10.22541/au.167784336.67563988/v1
Autor:
Melanie A. MacMullan, Yun Qu, Fangheng Hu, Gunce E. Cinay, Pin Wang, Zachary S. Dunn, Xianhui Chen, Hsuan-Yao Wang, Jiangyue Liu
Publikováno v:
Hum Gene Ther
Chimeric antigen receptor (CAR) T cell therapy mediates unprecedented benefit in certain leukemias and lymphomas, but has yet to achieve similar success in combating solid tumors. A substantial body of work indicates that the accumulation of adenosin
Autor:
Pin Wang, Xianhui Chen, Fangheng Hu, Yun Qu, Xiaoyang Zhang, Shuai Yang, Jiangyue Liu, Zachary S. Dunn, Si Li, Gunce E. Cinay, Melanie A. MacMullan, Hsuan-Yao Wang
Publikováno v:
Molecular Therapy: Oncolytics, Vol 21, Iss, Pp 144-157 (2021)
Molecular Therapy Oncolytics
Molecular Therapy Oncolytics
Despite the remarkable success of chimeric antigen receptor-modified T (CAR-T) cell therapy for blood malignancies, the clinical efficacy of this novel therapy in solid tumor treatment is largely limited by the immunosuppressive tumor microenvironmen
Autor:
Pierre M Jean Beltran, Vedakumar Tatavarty, Chi-Hong Wu, Andrea A Guerrero, Hasmik Keshishian, Karsten Krug, Melanie A MacMullan, Li Li, Steven A Carr, Jeffrey R Cottrell, Gina G Turrigiano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a34af56790b690b5fb058ed02112be07
https://doi.org/10.7554/elife.74277.sa2
https://doi.org/10.7554/elife.74277.sa2
Chimeric antigen receptors (CARs) are synthetic biomolecules comprised of an extracellular antigen recognition domain and intracellular signaling domains. When expressed in immune cells, CARs direct their host cells to kill diseased cells expressing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::084edf02964a5fd82155f46b5d926751
https://doi.org/10.1101/2022.02.24.481820
https://doi.org/10.1101/2022.02.24.481820
Autor:
Xiaoyang Zhang, Zumra Peksaglam Seidel, Melanie A. MacMullan, Nicholas A. Graham, Pin Wang, C. Ted Lee
Publikováno v:
ACS Applied Bio Materials. 3:7388-7398
Localized drug delivery holds great promise as a means of circumventing traditional chemotherapy side effects associated with high toxicity and prolonged treatments. Nanosized carriers (i.e., with diameters100 nm) can often accumulate in tumor cells,
Autor:
Aubree Mades, Prithivi Chellamathu, Noah Kojima, Lauren Lopez, Melanie A. MacMullan, Nicholas Denny, Aaron N. Angel, Marilisa Santacruz, Joseph G. Casian, Matthew Brobeck, Nina Nirema, Jeffrey D. Klausner, Frederick Turner, Vladimir I. Slepnev, Albina Ibrayeva
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
Scientific Reports
Scientific Reports
COVID-19 mRNA vaccines are highly effective at preventing COVID-19. Prior studies have found detectable SARS-CoV-2 IgG antibodies in oral mucosal specimens of participants with history of COVID-19. To assess the development of oral SARS-CoV-2 IgG ant