Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Melanie A Kleinschek"'
Autor:
Cristina St Pierre, Jane Guo, John D Shin, Laura W Engstrom, Hyun-Hee Lee, Alan Herbert, Laura Surdi, James Baker, Michael Salmon, Sanjiv Shah, J Michael Ellis, Hani Houshyar, Michael A Crackower, Melanie A Kleinschek, Dallas C Jones, Alexandra Hicks, Dennis M Zaller, Stephen E Alves, Ravisankar A Ramadas
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180870 (2017)
While the immune system is essential for the maintenance of the homeostasis, health and survival of humans, aberrant immune responses can lead to chronic inflammatory and autoimmune disorders. Pharmacological modulation of drug targets in the immune
Externí odkaz:
https://doaj.org/article/a511e5553a1e4c19982a055d21745012
Autor:
Raj Bhandari, M. Teresa Pulido-Rios, David T Beattie, Reuben Sana, Brihad Abhyankar, Jonathan A. Leighton, Jacky Woo, Richard Graham, Eva Situ, Ravi Ganeshappa, Erik Sandvik, Melanie A. Kleinschek, Whitney Krey, David L. Boyle, Deanna D Nguyen, Julián Panés, William J. Sandborn, Patrick Brassil
Publikováno v:
Journal of Crohn's & Colitis
Journal of Crohn's & colitis, vol 14, iss 9
Journal of Crohn's & colitis, vol 14, iss 9
Background and Aims Oral systemic pan-Janus kinase [JAK] inhibition is effective for ulcerative colitis [UC] but is limited by toxicities. We describe preclinical to clinical translation of TD-1473—an oral gut-selective pan-JAK inhibitor—from in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e5f63ccc3b54b28cf78acb55ba9f1eb
https://doi.org/10.1093/ecco-jcc/jjaa049
https://doi.org/10.1093/ecco-jcc/jjaa049
Autor:
Stephen E. Alves, Christine Fregeau, Nadim J. Ajami, Julia L. Cope, Michael Salmon, Jean-Philippe Laine, Nunzio Sciammetta, Hyun-Hee Lee, Heidi Ferguson, Melanie A. Kleinschek, Benjamin R. Umiker
Publikováno v:
Innate Immunity
Crohn’s disease (CD) is a chronic disorder of the gastrointestinal tract characterized by inflammation and intestinal epithelial injury. Loss of function mutations in the intracellular bacterial sensor NOD2 are major risk factors for the developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfa874f14b54bb52149878cc6fab7643
https://doi.org/10.1177/1753425919826367
https://doi.org/10.1177/1753425919826367
Autor:
Elad Kaufman, Thomas Scott, Thomas Southworth, Glenn Crater, Emma Gordon, Reuben Sana, Jacky Woo, Dave Singh, Melanie A. Kleinschek, Alexander McNamara, Edmund J. Moran, Nathan D. Pfeifer
Publikováno v:
Airway pharmacology and treatment.
Introduction: Janus kinase (JAK) enzymes mediate signaling of many cytokines associated with asthma. TD-8236 is a pan-JAK inhibitor designed to maximize lung selectivity. Aims: The aim of this study was to establish methods for detection of target en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88274f744a9d4b45638e13d320cc03d4
https://doi.org/10.1183/13993003.congress-2020.2891
https://doi.org/10.1183/13993003.congress-2020.2891
Autor:
Melissa Ho, Patrick Brassil, Sharath S. Hegde, M. Teresa Pulido-Rios, Fei Shen, David Beattie, Pam R. Tsuruda, Melanie A. Kleinschek, Eva Situ
Publikováno v:
Journal of Inflammation, Vol 14, Iss 1, Pp 1-11 (2017)
Journal of Inflammation (London, England)
Journal of Inflammation (London, England)
Background An unmet need remains for safe and effective treatments to induce and maintain remission in inflammatory bowel disease (IBD) patients. The Janus kinase (JAK) inhibitor, tofacitinib, has demonstrated robust efficacy in ulcerative colitis pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec948a665fc9cb7ccfe7583523a1ce3
http://link.springer.com/article/10.1186/s12950-017-0175-2
http://link.springer.com/article/10.1186/s12950-017-0175-2
Autor:
Whitney Krey-Epstein, Elad Kaufman, Erik Sandvik, Susan L. Calhoun, Paul R. Fatheree, Melanie A. Kleinschek, Joe Budman, Emma Gordon, Reuben Sana
Publikováno v:
Airway pharmacology and treatment.
Clinical studies with biologics have demonstrated the importance of cytokines in the pathobiology of asthma. However, redundancy and heterogeneity in the asthma cytokine networks may limit the efficacy of single cytokine-targeting biologics. Thus, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d512718c1b46176363dbb72f3bfe87f
https://doi.org/10.1183/13993003.congress-2019.pa3872
https://doi.org/10.1183/13993003.congress-2019.pa3872
Autor:
Ashleigh Heinichen, Alexander McNamara, Elad Kaufman, Melanie A. Kleinschek, Eva Situ, Paul Fatheree, Wanju Lee, Christina G. Campbell
Publikováno v:
Airway pharmacology and treatment.
Janus kinase (JAK) inhibitors target a family of kinases that transduce cytokine mediated signals via the JAK / Signal Transducer and Activator of Transcription (STAT) pathway. JAK/STAT signaling cytokines contribute to asthma airway inflammation. TD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59620c58a42ffd0f448ed35ee9b599f7
https://doi.org/10.1183/13993003.congress-2019.oa4952
https://doi.org/10.1183/13993003.congress-2019.oa4952
Autor:
Thomas Southworth, Nathan Pfeiffer, Glenn Crater, Elad Kaufman, Edmund J. Moran, Melanie A. Kleinschek, Emma Gordon, Thomas Scott, Dave Singh, Wanju Lee, Reuben Sana, Jacky Woo
Publikováno v:
Journal of Allergy and Clinical Immunology. 145:AB116
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af15aa2b25bfef11c649e697f5544bce
https://doi.org/10.1016/j.jaci.2019.12.570
https://doi.org/10.1016/j.jaci.2019.12.570
Autor:
Graham Smith, Michael D. Altman, Larissa Rakhilina, Dietrich Steinhuebel, Jason D. Brubaker, Craig R. Gibeau, John Maclean, Ruojing Yang, Erin F. Mulrooney, Hongmin Chen, James Baker, Charles A. Lesburg, Jeremy Presland, Lily Y. Moy, Melanie A. Kleinschek, Yiping Chen, Thierry O. Fischmann, Jongwon Lim, Erica Leccese
Publikováno v:
ACS Medicinal Chemistry Letters. 6:683-688
Interleukin-1 receptor associated kinase 4 (IRAK4) is an essential signal transducer downstream of the IL-1R and TLR superfamily, and selective inhibition of the kinase activity of the protein represents an attractive target for the treatment of infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b29635ca59f2ace046abac7d73ec3f0
https://doi.org/10.1021/acsmedchemlett.5b00107
https://doi.org/10.1021/acsmedchemlett.5b00107
Autor:
Jie Zhang-Hoover, Chaomin Li, Erin F. Mulrooney, Christian Fischer, Alan B. Northrup, Melanie A. Kleinschek, Jeremy Presland, Brian M. Andresen, Anthony Donofrio, Jason D. Brubaker, Matthew Lloyd Childers, Thierry O. Fischmann, Jongwon Lim, Alexander Hicks, Sue Jin, James Baker, Lilly Y. Moy, Hongmin Chen, Antoaneta S. Necheva, Luis E. Torres, Ruojing Yang, Michael D. Altman, Craig R. Gibeau, Duan Liu, Heidi Ferguson, Charles A. Lesburg, John Maclean, Erica Leccese, Faruk Mansoor, Graham Smith, Sam Kattar, Yiping Chen, Larissa Rakhilina
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(12)
Interleukin-1 receptor associated kinase 4 (IRAK4) has been implicated in IL-1R and TLR based signaling. Therefore selective inhibition of the kinase activity of this protein represents an attractive target for the treatment of inflammatory diseases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b65eb508a6ab7e6105827a694eda1d
https://pubmed.ncbi.nlm.nih.gov/28501511
https://pubmed.ncbi.nlm.nih.gov/28501511