Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Melanie A Huntley"'
Publikováno v:
Frontiers in Neuroscience, Vol 8 (2014)
The availability of genome-wide expression data for the blood-brain barrier is an invaluable resource that has recently enabled the discovery of several genes and pathways involved in the development and maintenance of the blood-brain barrier, partic
Externí odkaz:
https://doaj.org/article/d9e317ce75aa4a4cac3fe74707e4f42f
Autor:
Morgan Sheng, Karpagam Srinivasan, Jesse E. Hanson, Josh Kaminker, Yuanyuan Wang, Melanie A. Huntley, David V. Hansen, Tzu-Ming Wang, Brad A. Friedman, Ada X. Yee
Publikováno v:
J Neurosci
Cortical circuit activity is shaped by the parvalbumin (PV) and somatostatin (SST) interneurons that inhibit principal excitatory (EXC) neurons and the vasoactive intestinal peptide (VIP) interneurons that suppress activation of other interneurons. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4acf2db7d8aed3b93ac2b5cf28902762
https://doi.org/10.1523/jneurosci.1615-19.2019
https://doi.org/10.1523/jneurosci.1615-19.2019
Autor:
Seung-Hye Lee, Mitchell G. Rezzonico, Brad A. Friedman, Melanie H. Huntley, William J. Meilandt, Shristi Pandey, Ying-Jiun J. Chen, Amy Easton, Zora Modrusan, David V. Hansen, Morgan Sheng, Christopher J. Bohlen
Publikováno v:
Cell Reports. 37:110158
Non-neuronal responses in neurodegenerative disease have received increasing attention as important contributors to disease pathogenesis and progression. Here we utilize single-cell RNA sequencing to broadly profile 13 cell types in three different m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9bf97ad65dcc8fce051d9e2fc13e321
https://doi.org/10.1016/j.celrep.2021.110158
https://doi.org/10.1016/j.celrep.2021.110158
Alzheimer’s patient brain myeloid cells exhibit enhanced aging and unique transcriptional activation
Autor:
Marcel P. van der Brug, Brad A. Friedman, Geidy E. Serrano, Melanie A. Huntley, David V. Hansen, Thomas G. Beach, Oded Foreman, Ainhoa Etxeberria, Jonathan S. Paw, Karpagam Srinivasan, Zora Modrusan
Gene expression changes in brain microglia from mouse models of Alzheimer’s disease (AD) are highly characterized and reflect specific myeloid cell activation states that could modulate AD risk or progression. While some groups have produced valuab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5dd1b79ae6595bb06e8423346b3eb53
Autor:
Tiffany Wu, David V. Hansen, Michael C. Chang, William J. Meilandt, Borislav Dejanovic, Rose Edmonds, Tzu-Ming Wang, Oded Foreman, Alvin Gogineni, Kai H. Barck, Stephen P. Schauer, Jesse E. Hanson, Melanie A. Huntley, Maj Hedehus, Justin Elstrott, Karpagam Srinivasan, Morgan Sheng, Richard A.D. Carano, Vineela D. Gandham, Maya Stark, Yuanyuan Wang, Hai Ngu
Publikováno v:
Elsevier
Cell Reports, Vol 28, Iss 8, Pp 2111-2123.e6 (2019)
Cell Reports, Vol 28, Iss 8, Pp 2111-2123.e6 (2019)
Summary: Complement pathway overactivation can lead to neuronal damage in various neurological diseases. Although Alzheimer’s disease (AD) is characterized by β-amyloid plaques and tau tangles, previous work examining complement has largely focuse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6b7712fa67b1eb83140144dea67a46
https://pubmed.ncbi.nlm.nih.gov/31433986
https://pubmed.ncbi.nlm.nih.gov/31433986
Autor:
Borislav Dejanovic, Oded Foreman, Tiffany Wu, Morgan Sheng, Brad A. Friedman, Karpagam Srinivasan, Zhiyu Jiang, Ann De Mazière, Judith Klumperman, Corey E. Bakalarski, Melanie A. Huntley, William J. Meilandt, Jesse E. Hanson, Hai Ngu, Ben Chih, Vineela D. Gandham, Richard A.D. Carano
Publikováno v:
Neuron, 100(6), 1322. Cell Press
Summary Synapse loss and Tau pathology are hallmarks of Alzheimer’s disease (AD) and other tauopathies, but how Tau pathology causes synapse loss is unclear. We used unbiased proteomic analysis of postsynaptic densities (PSDs) in Tau-P301S transgen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5a36aac9ed5d931ab33812fae6a397
https://dspace.library.uu.nl/handle/1874/377288
https://dspace.library.uu.nl/handle/1874/377288
Autor:
Janis Allen, Charlotta Fruchtenicht, Melanie A. Huntley, Altovise Ewing, Anne-Marie Meyer, Yanling Jin, Sylvia Hu
Publikováno v:
Journal of Clinical Oncology. 39:6524-6524
6524 Background: Disparities in health outcomes can be affected by biological factors associated with GA and social determinants of health. These factors can be teased apart using GA data from comprehensive genomic profiling (CGP) in pts with cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b05c7c593385eb67fdd98d032adaaf4
https://doi.org/10.1200/jco.2021.39.15_suppl.6524
https://doi.org/10.1200/jco.2021.39.15_suppl.6524
Autor:
William J. Meilandt, Oded Foreman, Luke Xie, Christopher J. Bohlen, Brad A. Friedman, Amy Easton, Hai Ngu, David V. Hansen, Vineela D. Gandham, Richard A.D. Carano, Guita Lalehzadeh, Mitchell G. Rezzonico, Seung-Hye Lee, Kimberly L. Stark, Jose Imperio, Melanie A. Huntley, Kai H. Barck, Morgan Sheng
Publikováno v:
Neuron. 109:1283-1301.e6
Loss-of-function TREM2 mutations strongly increase Alzheimer's disease (AD) risk. Trem2 deletion has revealed protective Trem2 functions in preclinical models of β-amyloidosis, a prominent feature of pre-diagnosis AD stages. How TREM2 influences lat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec2c8a3c5d683db273bd161547979e2
https://doi.org/10.1016/j.neuron.2021.02.010
https://doi.org/10.1016/j.neuron.2021.02.010
Autor:
Mark S. Dennis, James A. Ernst, Christine Tan, Dara Y. Kallop, Raymond K. Tong, Xiaocheng Chen, Ben Chih, Melanie A. Huntley, Yanmei Lu, Shuo Zhang, Robby M. Weimer, Kwame Hoyte, Xiaoying Gao, Daniela Bumbaca, Y. Joy Yu Zuchero, Wilman Luk, Ryan J. Watts, Donald S. Kirkpatrick, Nga Bien-Ly, Lilian Phu
Publikováno v:
Neuron. 89:70-82
The blood-brain barrier (BBB) poses a major challenge for developing effective antibody therapies for neurological diseases. Using transcriptomic and proteomic profiling, we searched for proteins in mouse brain endothelial cells (BECs) that could pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dae591bf358ab346cdc8ebfb2a4ee8af
https://doi.org/10.1016/j.neuron.2015.11.024
https://doi.org/10.1016/j.neuron.2015.11.024
Autor:
Geidy E. Serrano, Thomas G. Beach, Oded Foreman, Ainhoa Etxeberria, Jonathan S. Paw, Melanie A. Huntley, Marcel P. van der Brug, Zora Modrusan, David V. Hansen, Karpagam Srinivasan, Brad A. Friedman
Publikováno v:
Cell reports
Cell Reports, Vol 31, Iss 13, Pp 107843-(2020)
Cell Reports, Vol 31, Iss 13, Pp 107843-(2020)
SUMMARY Damage-associated microglia (DAM) profiles observed in Alzheimer’s disease (AD)-related mouse models reflect an activation state that could modulate AD risk or progression. To learn whether human AD microglia (HAM) display a similar profile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc714abe523fc03206043f950ed7988
https://doi.org/10.1016/j.celrep.2020.107843
https://doi.org/10.1016/j.celrep.2020.107843