Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Melanie A Abboud"'
Autor:
Connie L. Erickson-Miller, Joseph A. Erhardt, Kodandaram Pillarisetti, Manuel Aivado, Melanie A Abboud, John R. Toomey
Publikováno v:
Experimental Hematology. 37:1030-1037
Objective The thrombopoietin receptor (TPOR) is a therapeutic target for treatment of thrombocytopenia because stimulation of this receptor results in enhanced megakaryocyte proliferation, differentiation, and ultimately platelet production. In addit
Autor:
Anthony J. Pateman, John R. Toomey, Paul F. Koster, Augustin Amour, Saul Needle, Laiq Chaudry, Melanie A Abboud, Champa Patel, Angela Patikis, Cynthia L. Burns-Kurtis, Robert J. Young, Richard E. Valocik, David Brown, Ping Zhou, Chuen Chan, Nigel S. Watson
Publikováno v:
Journal of Cardiovascular Pharmacology. 52:66-71
Background: Factor Xa (FXa) has been a target of considerable interest for drug development efforts aimed at suppressing thrombosis. In this report, a new orally active, small molecule, active-site directed FXa inhibitor, GW813893, has been profiled
Autor:
Joseph A. Erhardt, Richard E. Valocik, Kodandaram Pillarisetti, John R. Toomey, Cynthia L. Burns-Kurtis, Paul F. Koster, T. M. Danoff, Melanie A Abboud
Publikováno v:
Journal of thrombosis and haemostasis : JTH. 4(9)
Summary Background: A significant need exists for new chronic oral anticoagulation therapies to replace warfarin. Previous studies have shown that β-D-xylosides, which prime glycosaminoglycan (GAG) synthesis, have antithrombin and antithrombotic act