Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Melanie Adler"'
Autor:
Owen Daly, Azita Josefine Mahiny, Sara Majeski, Kevin McClintock, Julia Reichert, Gábor Boros, Gábor Tamás Szabó, Jonas Reinholz, Petra Schreiner, Steve Reid, Kieu Lam, Marlen Lepper, Melanie Adler, Tracy Meffen, James Heyes, Katalin Karikó, Pete Lutwyche, Irena Vlatkovic
Publikováno v:
Biomedicines, Vol 11, Iss 6, p 1735 (2023)
Argininosuccinic aciduria (ASA) is a metabolic disorder caused by a deficiency in argininosuccinate lyase (ASL), which cleaves argininosuccinic acid to arginine and fumarate in the urea cycle. ASL deficiency (ASLD) leads to hepatocyte dysfunction, hy
Externí odkaz:
https://doaj.org/article/25fe821524ea47a48910c484bef99572
Autor:
Vlatkovic, Owen Daly, Azita Josefine Mahiny, Sara Majeski, Kevin McClintock, Julia Reichert, Gábor Boros, Gábor Tamás Szabó, Jonas Reinholz, Petra Schreiner, Steve Reid, Kieu Lam, Marlen Lepper, Melanie Adler, Tracy Meffen, James Heyes, Katalin Karikó, Pete Lutwyche, Irena
Publikováno v:
Biomedicines; Volume 11; Issue 6; Pages: 1735
Argininosuccinic aciduria (ASA) is a metabolic disorder caused by a deficiency in argininosuccinate lyase (ASL), which cleaves argininosuccinic acid to arginine and fumarate in the urea cycle. ASL deficiency (ASLD) leads to hepatocyte dysfunction, hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::70340db4d8907d564b2348d655c7f221
Autor:
Edward J. Kelly, Susanne Ramm, Elijah J. Weber, Marc Hafner, Daniel L. Svoboda, Jonathan Himmelfarb, Vishal S. Vaidya, Jeremy L. Muhlich, Scott S. Auerbach, Alenka Jaklic, Melanie Adler, Amrendra Kumar Ajay, Esther Maria Gottwald
Publikováno v:
Journal of the American Society of Nephrology. 27:1015-1028
Nephrotoxicity due to drugs and environmental chemicals accounts for significant patient mortality and morbidity, but there is no high throughput in vitro method for predictive nephrotoxicity assessment. We show that primary human proximal tubular ep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3643c9c8f7a423a84c04fafa33f2c0
https://doi.org/10.1681/asn.2015010060
https://doi.org/10.1681/asn.2015010060
Autor:
Heidrun Ellinger-Ziegelbauer, Wolfgang Dekant, A. Rosenwald, Melanie Adler, Philip G. Hewitt, E. Leich, Angela Mally
Publikováno v:
Toxicology. 326:86-95
Inhibition of the glucagon receptor (GCGR) has been identified as a potential therapeutic approach for the treatment of type 2 diabetes. However, a small molecule drug candidate antagonizing GCGR (BAY16) failed during preclinical drug development, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd23d6cc32c47e40553292165b34e3ff
https://doi.org/10.1016/j.tox.2014.10.007
https://doi.org/10.1016/j.tox.2014.10.007
Publikováno v:
Current Protocols in Toxicology
Kidney toxicity due to drugs and chemicals poses a significant health burden for patients and a financial risk for pharmaceutical companies. However, currently no sensitive and high-throughput in vitro method exists for predictive nephrotoxicity asse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82841283f4fed0ed78522c214c7bd40
https://europepmc.org/articles/PMC4981919/
https://europepmc.org/articles/PMC4981919/
Publikováno v:
EFSA Supporting Publications. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7de04dbe248d5d8484f5030dc3089d52
https://doi.org/10.2903/sp.efsa.2016.en-1015
https://doi.org/10.2903/sp.efsa.2016.en-1015
Autor:
Dana Hoffmann, William M. Gallagher, John J. Callanan, Wolfgang Dekant, Heidrun Ellinger-Ziegelbauer, Angela Mally, Philip G. Hewitt, Katja Matheis, Laura Suter, Melanie Adler, Laoighse Mulrane, Michael Fountoulakis
Publikováno v:
Toxicology Letters. 196:1-11
This study was designed to assess the value of a set of potential markers for improved detection of liver injury in preclinical toxicity studies. Male Wistar rats were treated with drug candidates (BAY16, EMD335823, BI-3) that previously failed durin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::009c2a5a26efe9f1181b208b0626939a
https://doi.org/10.1016/j.toxlet.2010.03.018
https://doi.org/10.1016/j.toxlet.2010.03.018
Publikováno v:
Carcinogenesis. 30:711-719
Ochratoxin A (OTA) is a potent renal carcinogen, but little is known regarding the mechanism of OTA carcinogenicity. Early histopathological alterations induced by OTA in rat kidney include single cell death, stimulation of cell proliferation and pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43bf474133451dc658a3bbc67e0efce
https://doi.org/10.1093/carcin/bgp049
https://doi.org/10.1093/carcin/bgp049
Autor:
Heidrun Ellinger-Ziegelbauer, Brian C. Sweatman, John J. Callanan, Marian Raschke, Mark P. Hodson, Angela Mally, Arnd Brandenburg, Katja Matheis, Alexandra Sposny, Hans Gmuender, Diane McCarthy, Laura Suter, Björn Riefke, Albrecht Gruhler, Susan C. Connor, Alexander Amberg, Christina S. Schmitt, Max Sieber, Melanie Adler, Michael Fountoulakis, Philip Hewitt
Publikováno v:
Toxicology and applied pharmacology. 252(2)
The InnoMed PredTox consortium was formed to evaluate whether conventional preclinical safety assessment can be significantly enhanced by incorporation of molecular profiling (" omics" ) technologies. In short-term toxicological studies in rats, tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edd87394ca49ddc10b9fd3bc2f53ff95
https://pubmed.ncbi.nlm.nih.gov/20888850
https://pubmed.ncbi.nlm.nih.gov/20888850
Autor:
John J. Callanan, Heidrun Ellinger-Ziegelbauer, Arnd Brandenburg, Melanie Adler, William M. Gallagher, Katja Matheis, Alexandra Sposny, Joseph V. Bonventre, Frank Dieterle, Wolfgang Dekant, Frank Staedtler, Dana Hoffmann, Vishal S. Vaidya, Jean C. Gautier, Eva Rached, Angela Mally, Philip G. Hewitt, Laoighse Mulrane
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 116(1)
The kidney is one of the main targets of drug toxicity, but early detection of renal damage is often difficult. As part of the InnoMed PredTox project, a collaborative effort aimed at assessing the value of combining omics technologies with conventio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d117aa1aeacdc7146df5a208febeccdd
https://pubmed.ncbi.nlm.nih.gov/20118187
https://pubmed.ncbi.nlm.nih.gov/20118187